CHK2 Active Enzymes Active Kinases


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CHK2, Active (C48-10G)
Catalog Number Pack Size Price (USD)  
CHK2, Active C48-10G-05 5 ug $205   CHK2, Active Add to Cart
CHK2, Active C48-10G-10 10 ug $295   CHK2, Active Add to Cart
CHK2, Active C48-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human CHK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_007194
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~88 kDa

Gene Aliases : RP11-436C9.1, CDS1, CHEK2, HuCds1, LFS2, PP1425, RAD53

Scientific Background: CHK2 is rapidly phosphorylated and activated in response to replication blocks and DNA damage; the response to DNA damage occurs in an ataxia telangiectasia mutated (ATM)-dependent manner (1). Expression of wild-type Chk2 leads to increased p53 stabilization after DNA damage, whereas expression of a dominant-negative Chk2 mutant abrogated both phosphorylation of p53 on Ser-20 and p53 stabilization (2).

References: 
1. Matsuoka, S. et al: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7.

2. Chehab NH. et al: Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 2000 Feb 1;14(3):278-88.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




CHK2, Active Research Areas

The CHK2, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Ser/Thr Kinases



CHK2, Active Related Products Found: Total 7 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes CHK1, Active C47-10G Kinase Assay, Western Blot View CHK1, Active
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
Signaling Reagents Chktide C10-58 Kinase Assay View Chktide
Signaling Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Enzymes CHK1, Active C47-10H Kinase Assay, Western Blot View CHK1, Active
Antibodies Anti-CHK2 C48-60M WB View Anti-CHK2


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Product Types
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Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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