EPHA3 Active Enzymes Active Kinases


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EPHA3, Active (E15-11G)
Catalog Number Pack Size Price (USD)  
EPHA3, Active E15-11G-05 5 ug $205   EPHA3, Active Add to Cart
EPHA3, Active E15-11G-10 10 ug $295   EPHA3, Active Add to Cart
EPHA3, Active E15-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human EPHA3 (571-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 571-end
Genbank Number: BC063282
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~72kDa

Gene Aliases : ETK, HEK, ETK1, HEK4, TYRO4

Scientific Background: EPHA3 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. Analysis of human colorectal, breast, lung and pancreatic cancer samples shows somatic mutations in the EPHA3 gene (1). EPHA3 gene expression can be regulated by CD28 and IGF-1 in Jurkat cells and expression of EPHA3 is associated with adherence and motility of malignant T cells (2).

References: 
1. Wood, L D. et al: Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat. 2006 Oct;27(10):1060-1.

2. Smith, L M. et al: EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion. Exp Cell Res. 2004 Jan 15;292(2):295-303.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




EPHA3, Active Research Areas

The EPHA3, Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases



EPHA3, Active Related Products Found: Total 13 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes EPHA1, Active E13-11G Kinase Assay, Western Blot View EPHA1, Active
Enzymes EPHA2, Active E14-11G Kinase Assay, Western Blot View EPHA2, Active
Enzymes EPHB1, Active E21-11G Kinase Assay, Western Blot View EPHB1, Active
Enzymes EPHB2, Active E22-11G Kinase Assay, Western Blot View EPHB2, Active
Enzymes EPHB3, Active E23-11G Kinase Assay, Western Blot View EPHB3, Active
Enzymes EPHB4, Active E24-11G Kinase Assay, Western Blot View EPHB4, Active
Enzymes EPHA4, Active E16-11G Kinase Assay, Western Blot View EPHA4, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Enzymes EPHB4, Active E24-11H Kinase Assay, Western Blot View EPHB4, Active
Enzymes EPHA6, Active E18-11G Kinase Assay, Western Blot View EPHA6, Active
Enzymes EPHA1, Active E13-18G Kinase Assay, Western Blot View EPHA1, Active
Enzymes EPHA7, Active E19-11G Kinase Assay, Western Blot View EPHA7, Active
Signaling Proteins EPHA8 Protein E20-35G Western Blot View EPHA8 Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
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Enzymes Active Phosphatases Active Phosphatases
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Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
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Signaling Proteins Tau Proteins Tau Proteins
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Discovery Services
Compound Selective Profiling Compound Selective Profiling
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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