EPHB2 Active Enzymes Active Kinases


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EPHB2, Active (E22-11G)
Catalog Number Pack Size Price (USD)  
EPHB2, Active E22-11G-05 5 ug $205   EPHB2, Active Add to Cart
EPHB2, Active E22-11G-10 10 ug $295   EPHB2, Active Add to Cart
EPHB2, Active E22-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human EPHB2 (570-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 570-end
Genbank Number: NM_004442
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~66 kDa

Gene Aliases : DRT; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492

Scientific Background: EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neurodevelopmental processes such as boundary formation, axon guidance, vasculogenesis, and cell migration. EPHB2 has been shown to associate with the non-receptor tyrosine kinase Abl and activated EPHB2 causes tyrosine phosphorylation of Abl and regulates its activity (1). EPHB2 is overexpressed in a number of tumors particularly glioblastoma and this increases glioma cell migration and invasion (2).

References: 
1. Yu, H.H. et al: Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 2001 Jul 5;20(30):3995-4006.

2. Nakada, M. et al: The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 2004 May 1;64(9):3179-85.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




EPHB2, Active Research Areas

The EPHB2, Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases



EPHB2, Active Related Products Found: Total 14 Related Products
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Enzymes EPHB3, Active E23-11G Kinase Assay, Western Blot View EPHB3, Active
Enzymes EPHA1, Active E13-11G Kinase Assay, Western Blot View EPHA1, Active
Enzymes EPHB1, Active E21-11G Kinase Assay, Western Blot View EPHB1, Active
Enzymes EPHB4, Active E24-11G Kinase Assay, Western Blot View EPHB4, Active
Signaling Reagents Kinase Dilution Buffer IV K24-09 Kinase Assay View Kinase Dilution Buffer IV
Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Enzymes EPHA2, Active E14-11G Kinase Assay, Western Blot View EPHA2, Active
Enzymes EPHA3, Active E15-11G Kinase Assay, Western Blot View EPHA3, Active
Enzymes EPHA4, Active E16-11G Kinase Assay, Western Blot View EPHA4, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Enzymes EPHB4, Active E24-11H Kinase Assay, Western Blot View EPHB4, Active
Signaling Proteins ERK1, Unactive M29-14G Kinase Assay, Western Blot View ERK1, Unactive
Enzymes EPHA7, Active E19-11G Kinase Assay, Western Blot View EPHA7, Active


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Product Types
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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