MYLK3 Active Enzymes Active Kinases


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MYLK3, Active (M64-10G)
Catalog Number Pack Size Price (USD)  
MYLK3, Active M64-10G-05 5 ug $205   MYLK3, Active Add to Cart
MYLK3, Active M64-10G-10 10 ug $295   MYLK3, Active Add to Cart
MYLK3, Active M64-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human MYLK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: BC109097
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~135 kDa

Gene Aliases : caMLCK; MLCK, MLCK2, MGC126319, MGC126320

Scientific Background: MYLK3 (or myosin light chain kinase 3) plays a key role in rate of cross-bridge recruitment in cardiac myocytes. MYLK3 is upregulated in failing human myocardia and expression of MYLK3 correlates with the pulmonary arterial pressure of patients with heart failure (1). Knockdown of MYLK3 with small interfering RNAs in cultured rat cardiomyocytes decreases Myl2 phosphorylation and impairs epinephrine-induced activation of sarcomere reassembly (2). Recombinant murine MYLK3 shows specificity for Myl2 (Mlc2v) and the phosphorylation is calcium- and calmodulin-dependent.

References: 
1. Chan, J. Y. et al:Identification of cardiac-specific myosin light chain kinase. Circ. Res.2008; 102: 571-580.

2. Seguchi, O. et al: A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J. Clin. Invest. 2007;117: 2812-2824



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




MYLK3, Active Research Areas

The MYLK3, Active product can be utilized in the following research areas, but not limited to:

Cardiovascular Disease, PKA/PKC Pathway, Ser/Thr Kinases



MYLK3, Active Related Products Found: Total 4 Related Products
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Enzymes MLCK, Active M62-11G Kinase Assay, Western Blot View MLCK, Active
Signaling Reagents Ca2+/Calmodulin Solution II, 10x C02-39B Kinase Assay View Ca2+/Calmodulin Solution II, 10x
Signaling Reagents MRCL3 Peptide M56-58 Kinase Assay View MRCL3 Peptide


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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