PDGFR beta Active Enzymes Active Kinases


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PDGFR beta, Active (P13-11G)
Catalog Number Pack Size Price (USD)  
PDGFR beta, Active P13-11G-05 5 ug $205   PDGFR beta, Active Add to Cart
PDGFR beta, Active P13-11G-10 10 ug $295   PDGFR beta, Active Add to Cart
PDGFR beta, Active P13-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human PDGFRbeta (557-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 557-end
Genbank Number: NM_002609
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~104kDa

Gene Aliases : JTK12; PDGFR; CD140B; PDGFR1

Scientific Background: PDGFRβ (platelet-derived growth factor receptor ) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRβ deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRβ has no impact on major blood vessels and the heart. PDGFRβexpression and activity is elevated in several cancers and inhibition of PDGFRβ activity blocks progression of renal carcinoma in an animal model (2).

References: 
1. Soriano, P: Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994 Aug 15;8(16):1888-96.

2. Xu, L. et al: Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model. Cancer Res. 2005 Jul 1;65(13):5711-9.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PDGFR beta, Active Research Areas

The PDGFR beta, Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases



PDGFR beta, Active Related Products Found: Total 16 Related Products
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Extracellular Ligands PDGF P841-40N Cell Assay View PDGF


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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