PEAK1 Active Enzymes Active Kinases


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PEAK1, Active (P18-11G)
Catalog Number Pack Size Price (USD)  
PEAK1, Active P18-11G-05 5 ug $205   PEAK1, Active Add to Cart
PEAK1, Active P18-11G-10 10 ug $295   PEAK1, Active Add to Cart
PEAK1, Active P18-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human PEAK1 (1127-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 1127-end
Genbank Number: NM_024776
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~100 kDa

Gene Aliases: SGK269

Scientific Background: PEAK1 or Pseudopodium-enriched atypical kinase 1 is a protein tyrosine kinase which belongs to NKF3 kinase family and regulates the cytoskeleton and has been shown to be involved in cancer progression (1). PEAK1 promotes anchorage-independent growth in the MDA-MB-435 human cancer cell line and promotes tumor progression of XPA-1 human pancreatic cancer cells when transplanted into the pancreas of nude mice. PEAK1 is highly expressed in spleen, followed by heart, ovary, brain, lung, kidney, and fetal brain (2).

References: 
1. Wang, Y. et.al: Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc. Nat. Acad. Sci. 107: 10920-10925, 2010.

2. Ohara, O. et.al: Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. DNA Res. 9: 47-57, 2002.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PEAK1, Active Research Areas

The PEAK1, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway



PEAK1, Active Related Products Found: Total 5 Related Products
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Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Signaling Proteins PEAK1, Unactive P18-14G Kinase Assay, Western Blot View PEAK1, Unactive


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
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Enzymes Active Kinases Active Kinases
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Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
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Signaling Proteins
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Signaling Proteins Arginine Deiminases Arginine Deiminases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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