PIP5K1C Active Enzymes Active Kinases


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PIP5K1C, Active (P16-10CG)

Catalog Number Pack Size Price (USD)  
PIP5K1C, Active P16-10CG-05 5 ug $205   PIP5K1C, Active Add to Cart
PIP5K1C, Active P16-10CG-10 10 ug $295   PIP5K1C, Active Add to Cart
PIP5K1C, Active P16-10CG-BULK BULK CONTACT US  
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Bulk Pricing for PIP5K1C, Active

Product Data Sheet(s)




Description: Recombinant full-length human PIP5K1C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_012398
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~120 kDa

Gene Aliases: KIAA0589; LCCS3; PIP5K-GAMMA; PIP5Kgamma; PIPKIg_v4

Scientific Background: PIP5K1C or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with β-catenin and increases β-catenin activity downstream of growth factor stimulation (1). PIP5K1C expression and kinase activity enhance β-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitating RhoA GTPase and integrin activation by chemoattractants (2).

References
1. Schramp M. et al: PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res. 2011 Feb 15;71(4):1282-91.

2. Xu W, Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity. 2010 Sep 24;33(3):340-50.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PIP5K1C, Active Research Areas

The PIP5K1C, Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



PIP5K1C, Active Related Products Found: Total 14 Related Products
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Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active P27-15H Kinase Assay View PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PI3K (p110 delta/p85 alpha), Active P30-10H Kinase Assay, Western Blot View PI3K (p110 delta/p85 alpha), Active
Enzymes PI3K (p120 gamma), Active P29-10H Kinase Assay, Western Blot View PI3K (p120 gamma), Active
Enzymes PI4K2A, Active P21-10G Kinase Assay, Western Blot View PI4K2A, Active
Enzymes PI4K2B, Active P22-10G Kinase Assay, Western Blot View PI4K2B, Active
Enzymes PI4KB, Active P32-10G Kinase Assay, Western Blot View PI4KB, Active
Enzymes PIP4K2A, Active P76-10AG Kinase Assay, Western Blot View PIP4K2A, Active
Enzymes PIP5K1B, Active P16-10BG Kinase Assay, Western Blot View PIP5K1B, Active
Signaling Proteins PIP4K2B Protein P76-30BG Western Blot View PIP4K2B Protein
Signaling Proteins PIP5K3 Protein P17-31G Western Blot View PIP5K3 Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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