PKC iota Active Enzymes Active Kinases


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PKC iota, Active (P68-10G)
Catalog Number Pack Size Price (USD)  
PKC iota, Active P68-10G-05 5 ug $145   PKC iota, Active Add to Cart
PKC iota, Active P68-10G-10 10 ug $205   PKC iota, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human PKCiota was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_002740
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~98 kDa

Gene Aliases : PRKCI; DXS1179E; MGC26534; nPKC-iota

Scientific Background: PKCι is a member of the protein kinase C family of serine-threonine kinases. The amino acid sequence of PKCι showed greatest homology to PKCzeta, with 72% identity overall rising to 84% in the catalytic domain. Protein kinase C iota (PKCι) has been implicated in Ras signaling and is a critical downstream effector of oncogenic Ras in the colonic epithelium. Transgenic mice expressing constitutively active PKCι in the colon are highly susceptible to carcinogen-induced colon carcinogenesis (1).

References: 
1. Murray, N R. et al: Protein kinase C iota is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol. 2004 Mar 15;164(6):797-802.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PKC iota, Active Research Areas

The PKC iota, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



PKC iota, Active Related Products Found: Total 25 Related Products
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Enzymes PKC beta II, Active P63-10G Kinase Assay, Western Blot View PKC beta II, Active
Enzymes PKC delta, Active P64-10G Kinase Assay, Western Blot View PKC delta, Active
Enzymes PKC epsilon, Active P65-10G Kinase Assay, Western Blot View PKC epsilon, Active
Enzymes PKC gamma, Active P66-10G Kinase Assay, Western Blot View PKC gamma, Active
Enzymes PKC eta, Active P67-10G Kinase Assay, Western Blot View PKC eta, Active
Enzymes PKC mu, Active P72-10G Kinase Assay, Western Blot View PKC mu, Active
Enzymes PKC nu, Active P73-10G Kinase Assay, Western Blot View PKC nu, Active
Enzymes PKC zeta, Active P75-10G Kinase Assay, Western Blot View PKC zeta, Active
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents PKCtide P15-58 Kinase Assay View PKCtide
Enzymes PKC alpha, Active P61-18G Kinase Assay, Western Blot View PKC alpha, Active
Signaling Reagents PKC Lipid Activator, 10x L51-39 Kinase Assay View PKC Lipid Activator, 10x
Enzymes AMPK (A1/B1/G1), Active P47-10H Kinase Assay, Western Blot View AMPK (A1/B1/G1), Active
Enzymes PKC theta, Active P74-10G Kinase Assay, Western Blot View PKC theta, Active
Enzymes AMPK (A2/B1/G1), Active P48-10H Kinase Assay, Western Blot View AMPK (A2/B1/G1), Active
Enzymes AMPK (A1/B1/G2), Active P55-10H Kinase Assay, Western Blot View AMPK (A1/B1/G2), Active
Enzymes AMPK (A1/B1/G3), Active P56-10H Kinase Assay, Western Blot View AMPK (A1/B1/G3), Active
Enzymes AMPK (A1/B2/G1), Active P50-10H Kinase Assay, Western Blot View AMPK (A1/B2/G1), Active
Antibodies Anti-PKC delta P64-63R WB View Anti-PKC delta
Antibodies Anti-PKC theta P74-63R WB View Anti-PKC theta
Antibodies Anti-PKC mu P72-63R WB View Anti-PKC mu
Antibodies Anti-PKC zeta P75-63R WB View Anti-PKC zeta
Antibodies Anti-PKC delta/ theta P64-63DR WB View Anti-PKC delta/ theta
Antibodies Anti-PKC delta P64-63CR WB View Anti-PKC delta


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Extracellular Ligands
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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