PKC theta Active Enzymes Active Kinases


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PKC theta, Active (P74-10G)
Catalog Number Pack Size Price (USD)  
PKC theta, Active P74-10G-05 5 ug $205   PKC theta, Active Add to Cart
PKC theta, Active P74-10G-10 10 ug $295   PKC theta, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human PKCtheta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_006257
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~110 kDa

Gene Aliases : PRKCQ, PRKCT, MGC126514, MGC141919, nPKC-theta

Scientific Background: Protein Kinase C, theta (PKCθ) is important component in the intracellular signaling cascade (1). Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving PKC-theta leading to defects in insulin signaling and glucose transport in skeletal muscle (2). Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. PKC-theta is a crucial component mediating fat-induced insulin resistance in skeletal muscle and is a potential therapeutic target for the treatment of type 2 diabetes (2).

References: 
1. Manicassamy, S. and Sun, Z. The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis. J. Immunol. 2007;178(1):312-9.

2. Kim, J K. et al: PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 2004;114(6):823-7.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PKC theta, Active Research Areas

The PKC theta, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



PKC theta, Active Related Products Found: Total 24 Related Products
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Enzymes PKC beta I, Active P62-10G Kinase Assay, Western Blot View PKC beta I, Active
Enzymes PKC beta II, Active P63-10G Kinase Assay, Western Blot View PKC beta II, Active
Enzymes PKC delta, Active P64-10G Kinase Assay, Western Blot View PKC delta, Active
Enzymes PKC epsilon, Active P65-10G Kinase Assay, Western Blot View PKC epsilon, Active
Enzymes PKC gamma, Active P66-10G Kinase Assay, Western Blot View PKC gamma, Active
Enzymes PKC eta, Active P67-10G Kinase Assay, Western Blot View PKC eta, Active
Enzymes PKC iota, Active P68-10G Kinase Assay, Western Blot View PKC iota, Active
Signaling Reagents PKCtide P15-58 Kinase Assay View PKCtide
Enzymes PKC mu, Active P72-10G Kinase Assay, Western Blot View PKC mu, Active
Enzymes PKC nu, Active P73-10G Kinase Assay, Western Blot View PKC nu, Active
Enzymes PKC zeta, Active P75-10G Kinase Assay, Western Blot View PKC zeta, Active
Signaling Reagents PKC Lipid Activator, 10x L51-39 Kinase Assay View PKC Lipid Activator, 10x
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Enzymes AMPK (A1/B1/G1), Active P47-10H Kinase Assay, Western Blot View AMPK (A1/B1/G1), Active
Enzymes AMPK (A2/B1/G1), Active P48-10H Kinase Assay, Western Blot View AMPK (A2/B1/G1), Active
Antibodies Anti-PKC delta P64-63R WB View Anti-PKC delta
Antibodies Anti-PKC theta P74-63R WB View Anti-PKC theta
Antibodies Anti-PKC mu P72-63R WB View Anti-PKC mu
Antibodies Anti-PKC zeta P75-63R WB View Anti-PKC zeta
Antibodies Anti-PKC delta/ theta P64-63DR WB View Anti-PKC delta/ theta
Antibodies Anti-PKC delta P64-63CR WB View Anti-PKC delta
Signaling Reagents MARCKS Peptide M02-58 Kinase Assay View MARCKS Peptide


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Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
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Signaling Reagents
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Antibodies
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Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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