PKC zeta Active Enzymes Active Kinases


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PKC zeta, Active (P75-10G)
Catalog Number Pack Size Price (USD)  
PKC zeta, Active P75-10G-05 5 ug $145   PKC zeta, Active Add to Cart
PKC zeta, Active P75-10G-10 10 ug $205   PKC zeta, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human PKCzeta was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_002744
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~93 kDa

Gene Aliases : PRKCZ; PRKCZ; PKC2

Scientific Background:  PKCζ is an atypical isoform of the PKC family. PKCζ is found in both particulate and soluble fractions and cannot be activated by phorbol ester. Overexpression of PKCζ and subsequent phorbol ester treatment abolished phorbol ester-induced reduction in cell proliferation (1). Overexpression of PKCζ also potentiates phorbol ester-induced mitogen-activated protein (MAP) kinase activation in a PKC-dependent manner. PKCζ is an upstream modulator of p70S6K, an important regulator of cell proliferation (2).

References: 
1. Kim, SJ. Et al: Phorbol ester effects in atypical protein kinase C zeta overexpressing NIH3T3 cells: possible evidence for crosstalk between protein kinase C isoforms. Biochem Biophys Res Commun. 1997 Aug 18;237(2):336-9.

2. Romanelli, A. et al: p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol Cell Biol. 1999 Apr;19(4):2921-8.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PKC zeta, Active Research Areas

The PKC zeta, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



PKC zeta, Active Related Products Found: Total 25 Related Products
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Enzymes PKC delta, Active P64-10G Kinase Assay, Western Blot View PKC delta, Active
Enzymes PKC epsilon, Active P65-10G Kinase Assay, Western Blot View PKC epsilon, Active
Enzymes PKC gamma, Active P66-10G Kinase Assay, Western Blot View PKC gamma, Active
Enzymes PKC eta, Active P67-10G Kinase Assay, Western Blot View PKC eta, Active
Enzymes PKC iota, Active P68-10G Kinase Assay, Western Blot View PKC iota, Active
Enzymes PKC nu, Active P73-10G Kinase Assay, Western Blot View PKC nu, Active
Enzymes PKC mu, Active P72-10G Kinase Assay, Western Blot View PKC mu, Active
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents PKCtide P15-58 Kinase Assay View PKCtide
Enzymes PKC alpha, Active P61-18G Kinase Assay, Western Blot View PKC alpha, Active
Enzymes AMPK (A1/B1/G1), Active P47-10H Kinase Assay, Western Blot View AMPK (A1/B1/G1), Active
Enzymes PKC theta, Active P74-10G Kinase Assay, Western Blot View PKC theta, Active
Enzymes AMPK (A2/B1/G1), Active P48-10H Kinase Assay, Western Blot View AMPK (A2/B1/G1), Active
Enzymes AMPK (A1/B1/G2), Active P55-10H Kinase Assay, Western Blot View AMPK (A1/B1/G2), Active
Signaling Proteins NFATC1 Protein N12-30G Western Blot View NFATC1 Protein
Enzymes AMPK (A1/B1/G3), Active P56-10H Kinase Assay, Western Blot View AMPK (A1/B1/G3), Active
Enzymes AMPK (A1/B2/G1), Active P50-10H Kinase Assay, Western Blot View AMPK (A1/B2/G1), Active
Antibodies Anti-PKC delta P64-63R WB View Anti-PKC delta
Antibodies Anti-PKC theta P74-63R WB View Anti-PKC theta
Antibodies Anti-PKC mu P72-63R WB View Anti-PKC mu
Antibodies Anti-PKC zeta P75-63R WB View Anti-PKC zeta
Antibodies Anti-PKC delta/ theta P64-63DR WB View Anti-PKC delta/ theta
Antibodies Anti-PKC delta P64-63CR WB View Anti-PKC delta


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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