PLK1 Active Enzymes Active Kinases


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PLK1, Active (P41-10H)
Catalog Number Pack Size Price (USD)  
PLK1, Active P41-10H-05 5 ug $205   PLK1, Active Add to Cart
PLK1, Active P41-10H-10 10 ug $295   PLK1, Active Add to Cart
PLK1, Active P41-10H-BULK BULK CONTACT US  
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Bulk Pricing for PLK1, Active

Product Data Sheet(s)




Description: Recombinant full-length human PLK1 was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_005030
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~70 kDa

Gene Aliases: STPK13

Scientific Background: PLK1 is a member of the Polo-Like Kinase family that localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics (1). PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death (2).

References: 
1. Nigg, EA. et al: Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation. Exp Cell Res. 1996 Dec 15;229

2. Dai, W. et al: Polo-like kinases and the microtubule organization center: targets for cancer therapies. Prog Cell Cycle Res. 2003;5:327-34..



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PLK1, Active Research Areas

The PLK1, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Ser/Thr Kinases



PLK1, Active Related Products Found: Total 10 Related Products
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Enzymes AURORA A, Active A28-18G Kinase Assay, Western Blot View AURORA A, Active
Enzymes AURORA B, Active A31-10G Kinase Assay, Western Blot View AURORA B, Active
Enzymes LOK, Active S29-11G Kinase Assay, Western Blot View LOK, Active
Enzymes AURORA C, Active A33-10G Kinase Assay, Western Blot View AURORA C, Active
Enzymes PLK2, Active P42-10G Kinase Assay, Western Blot View PLK2, Active
Signaling Reagents Modified PLKtide P41-58B Kinase Assay View Modified PLKtide
Enzymes PLK3, Active P43-13G Kinase Assay, Western Blot View PLK3, Active
Enzymes PLK4, Active P44-11G Kinase Assay, Western Blot View PLK4, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Arginine Deiminases Arginine Deiminases
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Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
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Antibodies
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Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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