RSK2 Active Enzymes Active Kinases


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RSK2, Active (R17-10G)

Catalog Number Pack Size Price (USD)  
RSK2, Active R17-10G-05 5 ug $205   RSK2, Active Add to Cart
RSK2, Active R17-10G-10 10 ug $295   RSK2, Active Add to Cart
RSK2, Active R17-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human RSK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_004586
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~112 kDa

Gene Aliases: RPS6KA3; HU-3; MAPKAPK1B; CLS; MRX19; ISPK-1; p90-RSK2; pp90RSK2; S6K-alpha3

Scientific Background: RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).

References
1. Xing, J. et al: Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996 Aug 16;273(5277):959-63.

2. Jacquot, S. et al: Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. Am J Hum Genet. 1998 Dec;63(6):1631-40



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




RSK2, Active Research Areas

The RSK2, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases



RSK2, Active Related Products Found: Total 21 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
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Signaling Proteins ERK1, Unactive M29-14U Kinase Assay, Western Blot View ERK1, Unactive
Signaling Proteins ERK2, Unactive M28-14G Kinase Assay, Western Blot View ERK2, Unactive
Signaling Proteins ERK2, Unactive M28-14U Kinase Assay, Western Blot View ERK2, Unactive
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents RSK Substrate S06-58 Kinase Assay View RSK Substrate
Enzymes PDK1, Active P14-10H Kinase Assay, Western Blot View PDK1, Active
Enzymes RSK3, Active R16-10G Kinase Assay, Western Blot View RSK3, Active
Enzymes HER2, Active E27-11G Kinase Assay, Western Blot View HER2, Active
Enzymes MEK1 (EE), Active M02-12G Kinase Assay, Western Blot View MEK1 (EE), Active
Enzymes MNK2, Active M55-10G Kinase Assay, Western Blot View MNK2, Active
Enzymes ERK2, Active M28-10G Kinase Assay, Western Blot View ERK2, Active
Enzymes HER4, Active E29-11G Kinase Assay, Western Blot View HER4, Active
Signaling Proteins ELK1 Protein E64-30G Kinase Assay, Western Blot View ELK1 Protein
Enzymes RSK4, Active R20-10G Kinase Assay, Western Blot View RSK4, Active
Enzymes MSK1, Active R19-10G Kinase Assay, Western Blot View MSK1, Active
Enzymes MAPKAPK5, Active M42-10G Kinase Assay, Western Blot View MAPKAPK5, Active
Antibodies Anti-RSK (pan) R15-63BR WB View Anti-RSK (pan)
Enzymes MSK2, Active R18-10G Kinase Assay, Western Blot View MSK2, Active
Signaling Reagents S6K Substrate S05-58 Kinase Assay View S6K Substrate


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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