RSK2 Active Enzymes Active Kinases

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RSK2, Active (R17-10G)

Catalog Number Pack Size Price (USD)  
RSK2, Active R17-10G-05 5 ug $205   RSK2, Active Add to Cart
RSK2, Active R17-10G-10 10 ug $295   RSK2, Active Add to Cart
* Prices listed in the "shopping cart" are not discount inclusive. Promotional Prices will be applied internally during the processing of orders and net totals adjusted accordingly.

New Pack for RSK2, Active

Product Data Sheet(s)

Description: Recombinant full-length human RSK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_004586

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~112 kDa

Gene Aliases: RPS6KA3; HU-3; MAPKAPK1B; CLS; MRX19; ISPK-1; p90-RSK2; pp90RSK2; S6K-alpha3

Scientific Background: RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).

1. Xing, J. et al: Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science. 1996 Aug 16;273(5277):959-63.

2. Jacquot, S. et al: Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. Am J Hum Genet. 1998 Dec;63(6):1631-40

Formulation: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet

  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

RSK2, Active Research Areas

The RSK2, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases

RSK2, Active Related Products Found: Total 21 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes RSK1, Active R15-10G Kinase Assay, Western Blot View RSK1, Active
Enzymes ERK1, Active M29-10U Kinase Assay, Western Blot View ERK1, Active
Signaling Proteins ERK1, Unactive M29-14U Kinase Assay, Western Blot View ERK1, Unactive
Signaling Proteins ERK2, Unactive M28-14G Kinase Assay, Western Blot View ERK2, Unactive
Signaling Proteins ERK2, Unactive M28-14U Kinase Assay, Western Blot View ERK2, Unactive
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents RSK Substrate S06-58 Kinase Assay View RSK Substrate
Enzymes PDK1, Active P14-10H Kinase Assay, Western Blot View PDK1, Active
Enzymes RSK3, Active R16-10G Kinase Assay, Western Blot View RSK3, Active
Enzymes HER2, Active E27-11G Kinase Assay, Western Blot View HER2, Active
Enzymes MEK1 (EE), Active M02-12G Kinase Assay, Western Blot View MEK1 (EE), Active
Enzymes MNK2, Active M55-10G Kinase Assay, Western Blot View MNK2, Active
Enzymes ERK2, Active M28-10G Kinase Assay, Western Blot View ERK2, Active
Enzymes HER4, Active E29-11G Kinase Assay, Western Blot View HER4, Active
Signaling Proteins ELK1 Protein E64-30G Kinase Assay, Western Blot View ELK1 Protein
Enzymes RSK4, Active R20-10G Kinase Assay, Western Blot View RSK4, Active
Enzymes MSK1, Active R19-10G Kinase Assay, Western Blot View MSK1, Active
Enzymes MAPKAPK5, Active M42-10G Kinase Assay, Western Blot View MAPKAPK5, Active
Antibodies Anti-RSK (pan) R15-63BR WB View Anti-RSK (pan)
Enzymes MSK2, Active R18-10G Kinase Assay, Western Blot View MSK2, Active
Signaling Reagents S6K Substrate S05-58 Kinase Assay View S6K Substrate

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Product Types
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
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Enzymes Active Kinases Active Kinases
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Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
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Extracellular Ligands Chemokines Chemokines
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Discovery Services
Compound Selective Profiling Compound Selectivity Profiling
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling

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