TLK1 Active Enzymes Active Kinases


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TLK1, Active (T10-10G)
Catalog Number Pack Size Price (USD)  
TLK1, Active T10-10G-05 5 ug $205   TLK1, Active Add to Cart
TLK1, Active T10-10G-10 10 ug $295   TLK1, Active Add to Cart
TLK1, Active T10-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_012290
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~135 kDa

Gene Aliases: KIAA0137; PKU-beta

Scientific Background: TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint (1). The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1 (2).

References: 
1. Groth, A. et.al: Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J. 22: 1676-1687, 2003.

2. Krause, D. R. et.al: Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS and Chk1. Oncogene 22: 5927-5937, 2003.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




TLK1, Active Research Areas

The TLK1, Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Cancer, Cardiovascular Disease, Inflammation, Neurobiology, Receptor Tyrosine Kinases



TLK1, Active Related Products Found: Total 3 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes TLK2, Active T11-11G Kinase Assay, Western Blot View TLK2, Active
Enzymes CHK1, Active C47-10G Kinase Assay, Western Blot View CHK1, Active
Enzymes CHK1, Active C47-10H Kinase Assay, Western Blot View CHK1, Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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