p70S6K Active Enzymes Active Kinases


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p70S6K, Active (R21-10H)
Catalog Number Pack Size Price (USD)  
p70S6K, Active R21-10H-05 5 ug $205   p70S6K, Active Add to Cart
p70S6K, Active R21-10H-10 10 ug $295   p70S6K, Active Add to Cart
p70S6K, Active R21-10H-BULK BULK CONTACT US  
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Bulk Pricing for p70S6K, Active

Product Data Sheet(s)




Description: Recombinant full-length human p70S6K was expressed by baculovirus in Sf9 insect cells using a N-terminal His tag.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_003161
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~76 kDa

Gene Aliases : S6K; PS6K; S6K1; STK14A; RPS6KB1; p70-alpha; p70(S6K)-alpha

Scientific Background: p70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues (1). p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0 (2). p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1).

References: 
1. Ferrari, S. et al: S6 phosphorylation and the p70s6k/p85s6k. Crit Rev Biochem Mol Biol. 1994;29(6):385-413. Review.

2. Edelmann, HM. Et al: Cell cycle regulation of p70 S6 kinase and p42/p44 mitogen-activated protein kinases in Swiss mouse 3T3 fibroblasts. J Biol Chem. 1996 Jan 12;271(2):963-71.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




p70S6K, Active Research Areas

The p70S6K, Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases



p70S6K, Active Related Products Found: Total 31 Related Products
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Signaling Proteins AKT1, Unactive A16-14G Kinase Assay, Western Blot View AKT1, Unactive
Signaling Proteins AKT3, Unactive A18-14G Kinase Assay, Western Blot View AKT3, Unactive
Enzymes AKT2, Active A17-10G Kinase Assay, Western Blot View AKT2, Active
Signaling Reagents Crosstide C51-58 Kinase Assay View Crosstide
Signaling Reagents S6K Substrate S05-58 Kinase Assay View S6K Substrate
Enzymes PDK1, Active P14-10H Kinase Assay, Western Blot View PDK1, Active
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Signaling Proteins EIF4E Protein E34-30G Kinase Assay, Western Blot View EIF4E Protein
Enzymes AMPK (A2/B1/G1), Active P48-10H Kinase Assay, Western Blot View AMPK (A2/B1/G1), Active
Enzymes AMPK (A1/B1/G2), Active P55-10H Kinase Assay, Western Blot View AMPK (A1/B1/G2), Active
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Enzymes AMPK (A1/B1/G3), Active P56-10H Kinase Assay, Western Blot View AMPK (A1/B1/G3), Active
Enzymes AMPK (A1/B2/G1), Active P50-10H Kinase Assay, Western Blot View AMPK (A1/B2/G1), Active
Antibodies Anti-p70S6K R21-63R WB View Anti-p70S6K
Signaling Proteins BAX Protein B14-30G Western Blot View BAX Protein
Signaling Reagents 4EBP1 Protein E35-54G Kinase Assay, Western Blot View 4EBP1 Protein
Signaling Proteins AKT2, Unactive A17-15H Kinase Assay, Western Blot View AKT2, Unactive
Enzymes p70S6Kb, Active R22-10G Kinase Assay, Western Blot View p70S6Kb, Active
Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents Kinase Dilution Buffer I K21-09 Kinase Assay View Kinase Dilution Buffer I
Signaling Proteins p70S6Kb, Unactive R22-14G Kinase Assay, Western Blot View p70S6Kb, Unactive
Enzymes STK33, Active S46-10G Kinase Assay, Western Blot View STK33, Active
Antibodies Anti-p70S6K R21-63BR WB View Anti-p70S6K
Enzymes MSK2, Active R18-10G Kinase Assay, Western Blot View MSK2, Active
Signaling Proteins LKB1(STK11) Protein L15-30G Kinase Assay, Western Blot View LKB1(STK11) Protein
Signaling Proteins p70S6KL1 Protein R25-34G Western Blot View p70S6KL1 Protein
Signaling Proteins p70S6K, Unactive R21-14H Western Blot View p70S6K, Unactive


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Discovery Services
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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