Active Methyltransferases


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SignalChem's Active Methyltransferases

Methyltransferases catalyze the addition of methyl groups onto various types of substrates, including nucleic acids, small molecules and proteins. In proteins, this type of post translational modification (PTM) is involved in regulating protein-protein interactions, protein-DNA interactions, and protein activation. Methylation plays an important role epigenetic regulation, through which the modification of histones and DNA activate or silence the transcription of genes.


DNA methylation is important for genomic imprinting, X-chromosome inactivation, and suppression of repetitive DNA elements. Methylated DNA acts in two ways to silence transcription; by directly preventing transcription factors binding; and by recruiting additional transcriptional regulatory proteins to the modified region. On histones, lysine residues can be mono-, di- or tri-methylated, whereas arginines can only be mono- and di-methylated. Histone methylation alters the level chromatin condensation by affecting the net charge of the protein.


In cell signaling, methylation is required for activating protein phosphatases such as PP2A. PP2A is a tumor suppressor that targets many oncogenic serine/threonine kinases (STKs). PP2A methylation and demethylation is carried out by LCMT1 and PPME1 respectively.


SignalChem offers a wide range of methyltransferases to facilitate studies on this diverse group of enzymes.



Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
COMT, Active C339-381G Human GST tag Sf9 insect cells 27-271 NM_000754
DNMT3A, Active D353-380G Human GST tag Sf9 insect cells Full Length BC043617
DNMT3B, Active D353-380BG Human GST tag Sf9 insect cells Full Length BC111933
DNMT3L, Active D353-380CG Human GST tag Sf9 insect cells Full Length BC002560
DOT1L (KMT4), Active New Enzymes D344-381G Human GST tag Sf9 insect cells 1-435 NM_032482
EHMT1 (KMT1D), Active New Enzymes E317-381G Human GST tag Sf9 insect cells 895-end NM_024757
EHMT2, Active E318-381G Human GST tag Sf9 insect cells 807-end NM_006709
LCMT1, Active New Enzymes L321-380G Human GST tag Sf9 insect cells Full length NM_016309
MLL1 (KMT2A), Active New Enzymes M341-381G Human GST tag Sf9 insect cells 3738-end NM_005933
MLL2 (KMT2D), Active New Enzymes M342-381G Human GST tag Sf9 insect cells 5317-end NM_003482
MLL3 (KMT2C), Active New Enzymes M343-381G Human GST tag Sf9 insect cells 4689-end NM_170606
MLL5 (KMT2E), Active New Enzymes M345-381G Human GST tag Sf9 insect cells 1-548 NM_182931
N6AMT2, Active N355-380BH Human His tag Sf9 insect cells Full length NM_174928
NNMT, Active New Enzymes N330-380G Human GST tag Sf9 insect cells Full length NM_006169
PNMT, Active New Enzymes P331-380G Human GST tag Sf9 insect cells Full length NM_002686
PRMT1, Active P365-380G Human GST tag Sf9 insect cells Full Length Q99873-3
PRMT3, Active P365-380CG Human GST tag Sf9 insect cells Full Length BC064831
PRMT4, Active P365-380DG Human GST tag Sf9 insect cells Full length NM_199141
PRMT6, Active P365-380FG Human GST tag Sf9 insect cells Full length NM_018137
PRMT8, Active P365-380HG Human His tag Sf9 insect cells Full length BC022458
SETD1A (KMT2F), Active New Enzymes S342-381G Human GST tags Sf9 insect cells 1418-end NM_014712
SETD2 (KMT3A), Active New Enzymes S343-381G Human GST tag Sf9 insect cells 1425-1717 NM_014159
SETD6, Active New Enzymes S355-380G Human GST tag Sf9 insect cells Full length NM_001160305
SETD7, Active S344-380G Human GST tag Sf9 insect cells Full Length NM_030648
SMYD2 (KMT3C), Active S348-380BG Human GST tag Sf9 insect cells Full length BC049367
SMYD3, Active S348-380CG Human GST tag Sf9 insect cells Full length BC031010
SUV39H1 (KMT1A), Active S350-380G Human GST tag Sf9 insect cells Full length NM_003173
SUV39H2 (KMT1B), Active S350-380BG Human GST tag Sf9 insect cells Full length BC007754
SUV420H1 (KMT5B), Active S351-380G Human GST tag Sf9 insect cells Full length BC103498
WHSC1 (NSD2), Active New Enzymes N377-381G Human GST tag Sf9 insect cells 911-end NM_133330
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
COMT, Active C339-381G Human GST tag Sf9 insect cells 27-271 NM_000754
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
DNMT3A, Active D353-380G Human GST tag Sf9 insect cells Full Length BC043617
DNMT3B, Active D353-380BG Human GST tag Sf9 insect cells Full Length BC111933
DNMT3L, Active D353-380CG Human GST tag Sf9 insect cells Full Length BC002560
DOT1L (KMT4), Active New Enzymes D344-381G Human GST tag Sf9 insect cells 1-435 NM_032482
EHMT1 (KMT1D), Active New Enzymes E317-381G Human GST tag Sf9 insect cells 895-end NM_024757
EHMT2, Active E318-381G Human GST tag Sf9 insect cells 807-end NM_006709
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
LCMT1, Active New Enzymes L321-380G Human GST tag Sf9 insect cells Full length NM_016309
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
MLL1 (KMT2A), Active New Enzymes M341-381G Human GST tag Sf9 insect cells 3738-end NM_005933
MLL2 (KMT2D), Active New Enzymes M342-381G Human GST tag Sf9 insect cells 5317-end NM_003482
MLL3 (KMT2C), Active New Enzymes M343-381G Human GST tag Sf9 insect cells 4689-end NM_170606
MLL5 (KMT2E), Active New Enzymes M345-381G Human GST tag Sf9 insect cells 1-548 NM_182931
N6AMT2, Active N355-380BH Human His tag Sf9 insect cells Full length NM_174928
NNMT, Active New Enzymes N330-380G Human GST tag Sf9 insect cells Full length NM_006169
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PNMT, Active New Enzymes P331-380G Human GST tag Sf9 insect cells Full length NM_002686
PRMT1, Active P365-380G Human GST tag Sf9 insect cells Full Length Q99873-3
PRMT3, Active P365-380CG Human GST tag Sf9 insect cells Full Length BC064831
PRMT4, Active P365-380DG Human GST tag Sf9 insect cells Full length NM_199141
PRMT6, Active P365-380FG Human GST tag Sf9 insect cells Full length NM_018137
PRMT8, Active P365-380HG Human His tag Sf9 insect cells Full length BC022458
SETD1A (KMT2F), Active New Enzymes S342-381G Human GST tags Sf9 insect cells 1418-end NM_014712
SETD2 (KMT3A), Active New Enzymes S343-381G Human GST tag Sf9 insect cells 1425-1717 NM_014159
SETD6, Active New Enzymes S355-380G Human GST tag Sf9 insect cells Full length NM_001160305
SETD7, Active S344-380G Human GST tag Sf9 insect cells Full Length NM_030648
SMYD2 (KMT3C), Active S348-380BG Human GST tag Sf9 insect cells Full length BC049367
SMYD3, Active S348-380CG Human GST tag Sf9 insect cells Full length BC031010
SUV39H1 (KMT1A), Active S350-380G Human GST tag Sf9 insect cells Full length NM_003173
SUV39H2 (KMT1B), Active S350-380BG Human GST tag Sf9 insect cells Full length BC007754
SUV420H1 (KMT5B), Active S351-380G Human GST tag Sf9 insect cells Full length BC103498
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
WHSC1 (NSD2), Active New Enzymes N377-381G Human GST tag Sf9 insect cells 911-end NM_133330
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Methyltransferases Product Listing Found: Total 30 Products Matching Active Methyltransferases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number


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Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
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Biochemical Compounds siRNA Controls siRNA Controls
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Signaling Proteins
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