Active Phosphatases


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SignalChem's Active Phosphatases

Protein phosphatases are a group of enzymes that are found ubiquitously and are responsible for the dephosphorylation of various proteins and lipids in cells. In general, protein phosphatases antagonize the actions of protein kinases and this is an important control mechanism utilized by cells to regulate protein function.


Cellular proteins and lipids undergo cycles of phosphorylation and dephosphorylation reactions as part of post translational modification (ptm) in response to various stimuli such as growth factors, cytokines and hormones. Protein phosphatases regulate the phosphorylation state of many important signaling molecules and are a key regulatory component in signal transduction pathways involved in the control of cell growth, proliferation, differentiation and transformation.


In general, protein phosphatases display broad substrate specificity and can dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within proteins. Protein phosphatases have been identified as "druggable" targets and are being aggressively pursued for the treatment of various human diseases such as diabetes and cancer.


SignalChem offers a diverse and comprehensive range of active protein phosphatases and these can be tested using phosphorylated peptides, proteins or lipids as substrate.


Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
CDC25A, Active C04-20G Human GST tag Sf9 insect cells Full Length NM_001789
CDC25B, Active C04-20BG Human GST tag Sf9 insect cells Full Length NM_021873
CDC25C, Active C04-20CG Human GST tag Sf9 insect cells Full Length BC019089
DUSP22 (MKPX), Active D22-20G Human GST tag E.coli Full Length NM_020185
PP1A, Active P13-20G Human GST tag Sf9 insect cells Full Length NM_002708
PP1B, Active P14-20G Human GST tag Sf9 insect cells Full Length NM_002709
PP2A alpha/PPP2R1A Complex, Active P16-20BH Human His tags Sf9 insect cells Full length NM_002715
PP2Aalpha, Active P16-20G Human GST tag Sf9 insect cells Full Length NM_002715
PP2Calpha, Active P02-20G Human GST tag Sf9 insect cells Full Length NM_021003
PP2Cgamma, Active P07-20G Human GST tag Sf9 insect cells Full Length NM_177983
PTEN, Active P23-20G Human GST tag E.coli Full Length NM_000314
PTPN1 (PTP1B), Active P28-20G Human GST tag Sf9 insect cells Full Length NM_002827
PTPN11 (SHP2), Active P38-21G Human GST tag E.coli 246-593 NM_002834
PTPN12 (PTP-PEST), Active P39-21G Human GST tag E.coli 1-355 NM_002835
PTPN13 (FAP-1), Active P40-21G Human GST tag E.coli 2169-2485 NM_080683
PTPN2 (TC-PTP), Active P29-20G Human GST tag E.coli Full Length NM_080422
PTPN6 (SHP1), Active P33-20G Human GST tag E.coli Full Length NM_080548
PTPN6 (SHP1), Active New Enzymes P33-20H Human His tag E.coli Full length NM_0080548
PTPN7 (LC-PTP), Active P34-20G Human GST tag E.coli Full Length NM_002832
PTPRA (LRP), Active P48-21G Human GST tag E.coli 174-802 NM_002836
PTPRC (CD45), Active P50-21H Human His tag Sf9 insect cells 604-end NM_002838
PTPRC (CD45), Active P50-21BG Mouse GST tag E.coli 592-end NM_001111316
PTPRE, Active P52-21G Human GST tag Sf9 insect cells 75-end BC050062
PTPRF (LAR), Active P53-21G Human GST tag E.coli 1275-1897 NM_002840
PTPRJ (CD148), Active P56-21G Human GST tag Sf9 insect cells Full length NM_002843
PTPRS (PTP- sigma), Active P64-21G Human GST tag E.coli 883-1210 NM_130855
SHIP1, Active P08-20G Human GST tag Sf9 insect cells Full length NM_005541
SHIP2, Active P09-20G Human GST tag Sf9 insect cells Full length NM_001567
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
CDC25A, Active C04-20G Human GST tag Sf9 insect cells Full Length NM_001789
CDC25B, Active C04-20BG Human GST tag Sf9 insect cells Full Length NM_021873
CDC25C, Active C04-20CG Human GST tag Sf9 insect cells Full Length BC019089
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
DUSP22 (MKPX), Active D22-20G Human GST tag E.coli Full Length NM_020185
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PP1A, Active P13-20G Human GST tag Sf9 insect cells Full Length NM_002708
PP1B, Active P14-20G Human GST tag Sf9 insect cells Full Length NM_002709
PP2A alpha/PPP2R1A Complex, Active P16-20BH Human His tags Sf9 insect cells Full length NM_002715
PP2Aalpha, Active P16-20G Human GST tag Sf9 insect cells Full Length NM_002715
PP2Calpha, Active P02-20G Human GST tag Sf9 insect cells Full Length NM_021003
PP2Cgamma, Active P07-20G Human GST tag Sf9 insect cells Full Length NM_177983
PTEN, Active P23-20G Human GST tag E.coli Full Length NM_000314
PTPN1 (PTP1B), Active P28-20G Human GST tag Sf9 insect cells Full Length NM_002827
PTPN11 (SHP2), Active P38-21G Human GST tag E.coli 246-593 NM_002834
PTPN12 (PTP-PEST), Active P39-21G Human GST tag E.coli 1-355 NM_002835
PTPN13 (FAP-1), Active P40-21G Human GST tag E.coli 2169-2485 NM_080683
PTPN2 (TC-PTP), Active P29-20G Human GST tag E.coli Full Length NM_080422
PTPN6 (SHP1), Active P33-20G Human GST tag E.coli Full Length NM_080548
PTPN6 (SHP1), Active New Enzymes P33-20H Human His tag E.coli Full length NM_0080548
PTPN7 (LC-PTP), Active P34-20G Human GST tag E.coli Full Length NM_002832
PTPRA (LRP), Active P48-21G Human GST tag E.coli 174-802 NM_002836
PTPRC (CD45), Active P50-21H Human His tag Sf9 insect cells 604-end NM_002838
PTPRC (CD45), Active P50-21BG Mouse GST tag E.coli 592-end NM_001111316
PTPRE, Active P52-21G Human GST tag Sf9 insect cells 75-end BC050062
PTPRF (LAR), Active P53-21G Human GST tag E.coli 1275-1897 NM_002840
PTPRJ (CD148), Active P56-21G Human GST tag Sf9 insect cells Full length NM_002843
PTPRS (PTP- sigma), Active P64-21G Human GST tag E.coli 883-1210 NM_130855
SHIP1, Active P08-20G Human GST tag Sf9 insect cells Full length NM_005541
SHIP2, Active P09-20G Human GST tag Sf9 insect cells Full length NM_001567
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphatases Product Listing Found: Total 28 Products Matching Active Phosphatases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number


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Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
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