Active Phosphodiesterases


HomeProducts: Enzymes - Active Phosphodiesterases

SignalChem's Active Phosphodiesterases

Phosphodiesterases or PDEs are a multigenic enzyme superfamily that is ubiquitously distributed in mammalians and is involved in intracellular signaling. The PDE superfamily is comprised of 21 genes that are represented by more than 100 mRNA products due to alternative splicing. The various PDE proteins specifically control the intracellular levels of cAMP and cGMP and regulate the localization, duration, and amplitude of the cyclic nucleotide signal.


PDEs represent important therapeutic targets in the treatment of various diseases including inflammation, cardiovascular disease and neurological disorders like dementia as well as erectile dysfunction. Among the various PDE family members, PDE3, PDE4 and PDE5 have been exploited as therapeutic targets with the successful development of at least 7 drugs.


Overexpression of PDE isoforms and impaired cAMP and/or cGMP generation has also been described in various cancer pathologies. Inhibition of selective PDE isoforms, which raises the levels of intracellular cAMP and/or cGMP, induces apoptosis and cell cycle arrest in a broad spectrum of tumour cells and regulates the tumour microenvironment.


PDE inhibitors can act as broad-spectrum neuroprotective agents acting through modulation of cell cycle elements and may display novel mode of action in Neurobiology science. PDEs are involved in various pathogenic mechanisms that lead to Alzheimer's disease (AD) which includes neuronal apoptosis, neurovascular dysfunction, neurotransmitter modulation, and impairment of neurogenesis. SignalChem offers a diverse and comprehensive range of active PDEs and these can be tested using cAMP and/or cGMP as substrate.


Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PDE10A, Active P98-31G Human GST tag Sf9 insect cells 71-end NM_006661
PDE1A, Active P89-30H Human His tag Sf9 insect cells Full Length NM_005019
PDE1B, Active P89-30BG Human GST tag Sf9 insect cells Full Length NM_000924
PDE1C, Active P89-30CG Human GST tag Sf9 insect cells Full Length NM_005020
PDE2A, Active P90-30G Human GST tag Sf9 insect cells Full Length NM_002599
PDE3A, Active P91-31G Human GST tag Sf9 insect cells 669-end NM_000921
PDE3B, Active P91-31BG Human GST tag Sf9 insect cells 654-end NM_000922
PDE4A, Active P92-31G Human GST tag Sf9 insect cells 332-end NM_001111307
PDE4B, Active P92-31BG Human GST tag Sf9 insect cells 305-end NM_002600
PDE4C, Active P92-31CG Human GST tag Sf9 insect cells 287-end NM_000923
PDE4D, Active P92-31DG Human GST tag Sf9 insect cells 225-end NM_006203
PDE5A, Active P93-31G Human GST tag Sf9 insect cells 537-end NM_001083
PDE6A, Active P94-31G Human GST tag Sf9 insect cells 31-end NM_000440
PDE6B, Active P94-30BG Human GST tag Sf9 insect cells Full Length NM_000283
PDE7A, Active P95-31G Human GST tag Sf9 insect cells 104-end NM_002603
PDE7B, Active P95-30BG Human GST tag Sf9 insect cells Full Length NM_018945
PDE8A, Active P96-30G Human GST tag Sf9 insect cells Full Length NM_002605
PDE8B, Active P96-31BG Human GST tag Sf9 insect cells 113-end NM_003719
PDE9A, Active P97-30G Human GST tag Sf9 insect cells Full Length NM_001001567
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
PDE10A, Active P98-31G Human GST tag Sf9 insect cells 71-end NM_006661
PDE1A, Active P89-30H Human His tag Sf9 insect cells Full Length NM_005019
PDE1B, Active P89-30BG Human GST tag Sf9 insect cells Full Length NM_000924
PDE1C, Active P89-30CG Human GST tag Sf9 insect cells Full Length NM_005020
PDE2A, Active P90-30G Human GST tag Sf9 insect cells Full Length NM_002599
PDE3A, Active P91-31G Human GST tag Sf9 insect cells 669-end NM_000921
PDE3B, Active P91-31BG Human GST tag Sf9 insect cells 654-end NM_000922
PDE4A, Active P92-31G Human GST tag Sf9 insect cells 332-end NM_001111307
PDE4B, Active P92-31BG Human GST tag Sf9 insect cells 305-end NM_002600
PDE4C, Active P92-31CG Human GST tag Sf9 insect cells 287-end NM_000923
PDE4D, Active P92-31DG Human GST tag Sf9 insect cells 225-end NM_006203
PDE5A, Active P93-31G Human GST tag Sf9 insect cells 537-end NM_001083
PDE6A, Active P94-31G Human GST tag Sf9 insect cells 31-end NM_000440
PDE6B, Active P94-30BG Human GST tag Sf9 insect cells Full Length NM_000283
PDE7A, Active P95-31G Human GST tag Sf9 insect cells 104-end NM_002603
PDE7B, Active P95-30BG Human GST tag Sf9 insect cells Full Length NM_018945
PDE8A, Active P96-30G Human GST tag Sf9 insect cells Full Length NM_002605
PDE8B, Active P96-31BG Human GST tag Sf9 insect cells 113-end NM_003719
PDE9A, Active P97-30G Human GST tag Sf9 insect cells Full Length NM_001001567
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number
Active Phosphodiesterases Product Listing Found: Total 19 Products Matching Active Phosphodiesterases
Product Name Catalog Number Species Tag Expression System Sequence Genbank Number


Items in Your Cart (0)
Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Lipid Kinases Active Lipid Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Enzymes Active Proteases Active Proteases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Epigenetic Enzyme Activators Epigenetic Enzyme Activators
Biochemical Compounds Epigenetic Enzyme Inhibitors Epigenetic Enzyme Inhibitors
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds Phosphatase Inhibitors Phosphatase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dihydropyrimidinase Dihydropyrimidinase
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Kinase Mutant Proteins Kinase Mutant Proteins
Signaling Proteins Kinase Protein Kinase Protein
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Phospholipase C Proteins Phospholipase C Proteins
Signaling Proteins Superoxide Dismutase Superoxide Dismutase
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Lipid Substrates Lipid Substrates
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selectivity Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




Keep in touch, join us on:
Active Phosphodiesterases   Active Phosphodiesterases   Active Phosphodiesterases