Description: Recombinant full-length human GH (Growth Hormone) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Formulation: Recombinant protein stored in 1 X PBS, 10% glycerol.

Storage, Stability, and Shipping: Stored at desiccated below -20^oC. It is stable at 4^oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Cell Assay

Endotoxin Level: Less than 0.1 ng/µg (IEU/µg) of hGH

Molecular Weight: ~22.3 kDa

Gene Aliases: GH; GHN; GH-N; hGH-N; IGHD1B

Scientific Background: hGH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control and it is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. hGH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland (1).The systemic inhibition of GH or IGF1, or both, may have therapeutic potential in preventing some forms of retinopathy (2).

References: 
1. Niall, H. D. et.al: Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc. Nat. Acad. Sci. 68: 866-869, 1971.

2. Smith, L. E. H. et.al: Essential role of growth hormone in ischemia-induced retinal neovascularization. Science 276: 1706-1709, 1997.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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