Description: Human active form BMP-4 (293-408) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Formulation: Recombinant protein stored in 1 X PBS, 10% glycerol.

Storage, Stability, and Shipping: Stored at desiccated below -20^oC. It is stable at 4^oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Cell Assay

Endotoxin Level: Less than 0.1 ng/μg (IEU/μg) of BMP-4.

Molecular Weight: ~13.5 kDa

Gene Aliases: ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP4

Scientific Background: BMP4 is a member of the bone morphogenetic protein family that is part of the transforming growth factor-beta superfamily. BMP4 plays an important role in the onset of endochondral bone formation in humans and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva (1). BMP4 acts as a novel, noncytotoxic therapeutic effector that is used to prevent growth and recurrence of glioblastomas in humans (2).

References: 
1. Kan, L., et.al: Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Path. 165: 1107-1115, 2004.

2. Piccirillo, S. G. M. et.al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765, 2006.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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