Description: Recombinant human TGFbetaR2 (190-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~68 kDa

Gene Aliases: AAT3, FAA3, MFS2, RIIC, HNPCC6, TGFR-2, TGFbeta-RII, TAAD2

Scientific Background: TGFβR2 is a member of the TGFβ receptor subfamily and is a ser/thr protein kinase. TGFβR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses (1). The TGFβR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFβR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors (2).

References: 
1. Cheng, N. et al. Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis." Cancer Res. 2007;67(10):4869-77.

2. Sakai, H. et al. Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes. Am. J. Med. Genet. 2006; 140(16):1719-25.

		Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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