ALK4 Active Enzymes Active Kinases


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ALK4, Active (A07-11G)

Catalog Number Pack Size Price (USD)  
ALK4, Active A07-11G-05 5 ug $205   ALK4, Active Add to Cart
ALK4, Active A07-11G-10 10 ug $295   ALK4, Active Add to Cart
ALK4, Active A07-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human ALK4 (150-end) was expressed in Sf9 cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 150-end
Genbank Number: NM_004302
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~64 kDa

Gene Aliases: ACVR1B, SKR2, ACTRIB, ACVRLK4

Scientific Background: ALK4 is a member of the subfamily of receptor ser/thr kinases that mediates signaling by the Activins. ALK4 is expressed in many human tissues, including kidney, pancreas, brain, lung, and liver. Truncated ALK4, predominantly expressed in human pituitary adenomas, function as dominant negative receptors to interfere with wild-type receptor function and blocks the antiproliferative effect of activin possibly contributing to development of human pituitary tumors (1). ALK4 is able to mediate Nodal signaling in the presence of Cripto during vertebrate development (2).

References
1. Zhou, Y. et al: Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling. Mol Endocrinol. 2000 Dec;14(12):2066-75.

2. Reissmann, E. et al: The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. Genes Dev. 2001 Aug 1;15(15):2010-22.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




ALK4, Active Research Areas

The ALK4, Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases



ALK4, Active Related Products Found: Total 8 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes ALK1, Active A09-11G Kinase Assay, Western Blot View ALK1, Active
Enzymes ALK2, Active A06-11G Kinase Assay, Western Blot View ALK2, Active
Signaling Proteins TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
Signaling Reagents TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
Enzymes ALK3 (BMPR1A), Active B04-11G Kinase Assay, Western Blot View ALK3 (BMPR1A), Active
Enzymes TGFBR1 (ALK5), Active T07-11G Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Enzymes ALK6 (BMPR1B), Active B05-11G Kinase Assay, Western Blot View ALK6 (BMPR1B), Active
Signaling Proteins ALK7 Protein A08-35G Western Blot View ALK7 Protein


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Enzymes Active Acetyltransferases Active Acetyltransferases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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