Anti-MEK1/2 Antibodies Primary Antibodies


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Anti-MEK1/2 (M02-63R)

Catalog Number Pack Size Price (USD)  
Anti-MEK1/2 M02-63R-100 100 ug $245   Anti-MEK1/2 Add to Cart
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Product Data Sheet(s)




Description: Rabbit Polyclonal Antibody
Specificity: Recognizes the MEK1and MEK2 proteins

Cited Applications: WB

Cross Reactivity: Western blot human MEK1 and MEK2

MEK1and MEK2 from other species may also be detectable

Host: Rabbit

Immunogen: Synthesized peptide corresponding to human MEK1 (210-220 aa) protein

Formulation: TBS, 50% glycerol

Purification: Affinity purified using Protein G

Stability: Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background: MEK1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).

References
1. Seger, R. et al: The MAPK signaling cascade. FASEB J. 9: 726-735, 1995.

2. Sebolt-Leopold, J S. et al: Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5: 810-816, 1999.



  Sample Western Blot:   Representative western blot with Anti-MEK1/2 (1:1000) using 10 μg, 20 μg, and 40 μg of 293 cell lysate.


  Sample Immunoprecipitation:  Representative immunoprecipitation with Anti-MEK1/2 (1:1000) using 30ng of His-MEK1 and GST-MEK2 recombinant proteins.




Anti-MEK1/2 Research Areas

The Anti-MEK1/2 product can be utilized in the following research areas, but not limited to:

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology



Anti-MEK1/2 Related Products Found: Total 9 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins MEK2, Unactive M03-14G Kinase Assay, Western Blot View MEK2, Unactive
Enzymes MEK1 (EE), Active M02-12G Kinase Assay, Western Blot View MEK1 (EE), Active
Enzymes MEK1, Active M02-10G Kinase Assay, Western Blot View MEK1, Active
Signaling Proteins MEK1, Unactive M02-14H Kinase Assay, Western Blot View MEK1, Unactive
Antibodies Anti-MEK2 M03-63R WB View Anti-MEK2
Antibodies Anti-MEK1 M02-60M WB, IP View Anti-MEK1
Enzymes MEK2, Active M03-10G Kinase Assay, Western Blot View MEK2, Active
Signaling Proteins MEK1, Unactive M02-14BG Kinase Assay, Western Blot View MEK1, Unactive
Signaling Reagents MEK1 (K97A), Unactive M02-16H Kinase Assay, Western Blot View MEK1 (K97A), Unactive


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
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Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
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Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
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Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selective Profiling
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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