PIK3C3 (Vps34) Active Enzymes Active Kinases


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PIK3C3 (Vps34), Active (P26-10G)

Catalog Number Pack Size Price (USD)  
PIK3C3 (Vps34), Active P26-10G-05 5 ug $205   PIK3C3 (Vps34), Active Add to Cart
PIK3C3 (Vps34), Active P26-10G-10 10 ug $295   PIK3C3 (Vps34), Active Add to Cart
PIK3C3 (Vps34), Active P26-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human PIK3C3 (Vps34) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_002647
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~128 kDa

Gene Aliases: VPS34, hVps34, MGC61518

Scientific Background: PIK3C3 or phosphoinositide-3-kinase is a member of the PI 3-kinase family that mediates the active diversion of proteins from the secretory pathway to vacuoles. PIK3C3 are involved in both receptor-mediated signal transduction and intracellular trafficking. In yeast, the vps34 gene product is a PI 3-kinase. PIK3C3 has a substrate specificity and ion requirements that are distinct from the other known mammalian PI 3-kinases (1). PIK3C3 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles. PIK3C3 appears to alternate between a closed cytosolic form and an open form on the membrane (2).

References
1. Volinia, S. et.al: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14: 3339-3348, 1995.

2. Miller, S. et.al: Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 327: 1638-1642, 2010.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PIK3C3 (Vps34), Active Research Areas

The PIK3C3 (Vps34), Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



PIK3C3 (Vps34), Active Related Products Found: Total 13 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active P27-15H Kinase Assay View PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-10H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 beta), Active P28-10BH Kinase Assay, Western Blot View PI3K (p110 beta/p85 beta), Active
Enzymes PI3K (p110 delta/p85 alpha), Active P30-10H Kinase Assay, Western Blot View PI3K (p110 delta/p85 alpha), Active
Enzymes PI3K (p120 gamma), Active P29-10H Kinase Assay, Western Blot View PI3K (p120 gamma), Active
Signaling Proteins PI3K (p85 alpha) Protein P31-30H Kinase Assay, Western Blot View PI3K (p85 alpha) Protein
Signaling Proteins PI3K (p85 beta) Protein P31-30BH Kinase Assay, Western Blot View PI3K (p85 beta) Protein
Enzymes PI4K2A, Active P21-10G Kinase Assay, Western Blot View PI4K2A, Active
Enzymes PI4K2B, Active P22-10G Kinase Assay, Western Blot View PI4K2B, Active
Enzymes PIK3C2G, Active P25-11G Kinase Assay, Western Blot View PIK3C2G, Active
Signaling Proteins PIK3C2B Protein P24-31BG Western Blot View PIK3C2B Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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