HSF1 Protein Cell Signaling Reagents Transcription Proteins


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HSF1 Protein (H25-30G)
Catalog Number Pack Size Price (USD)  
HSF1 Protein H25-30G-20 20 ug $195 HSF1 Protein  40% OFF   HSF1 Protein Add to Cart
HSF1 Protein H25-30G-50 50 ug $395 HSF1 Protein  40% OFF   HSF1 Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full length human HSF1 was expressed in E. coli cells using a N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_005526
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~96 kDa

Gene Aliases: HSTF1

Scientific Background: HSF1 is a member of the heat shock transcription factor family. Protein-damaging stress lead to the activation of HSF1 which binds to upstream regulatory sequences in the promoters of heat shock genes leading to enhanced heat shock gene expression (1). The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. HSF1 activity is regulated at different levels by heat shock proteins and co-chaperones and is modulated further by a number of mechanisms involving other stress-regulated aspects of cell metabolism (2).

References: 
1. Pirkkala, L. et al: Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001 May;15(7):1118-31.

2. Voellmy, R.: Feedback regulation of the heat shock response. Handb Exp Pharmacol. 2006;(172):43-68.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




HSF1 Protein Research Areas

The HSF1 Protein product can be utilized in the following research areas, but not limited to:

Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway



HSF1 Protein Related Products Found: Total 10 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins HSP10 Protein H29-54G Western Blot View HSP10 Protein
Signaling Proteins HSP27 Protein H30-54G Kinase Assay, Western Blot View HSP27 Protein
Signaling Proteins HSP40 Protein H32-54G Western Blot View HSP40 Protein
Signaling Proteins HSP70 Protein H34-54G ATPase Assay, Western Blot View HSP70 Protein
Signaling Proteins HSP70 Protein H34-54H ATPase Assay, Western Blot View HSP70 Protein
Signaling Proteins HSP90 beta Protein H36-54H ATPase Assay, Western Blot View HSP90 beta Protein
Signaling Proteins 14-3-3 epsilon Protein Y75-30G Western Blot View 14-3-3 epsilon Protein
Signaling Proteins HSP90 alpha Protein H36-50H Western Blot View HSP90 alpha Protein
Signaling Proteins 14-3-3 epsilon Protein Y75-30N Western Blot View 14-3-3 epsilon Protein
Antibodies Anti-HSF1 H25-63R WB View Anti-HSF1


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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