Storage, Stability, and Shipping: Store product at –70
oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Western Blot
Molecular Weight: ~61 kDa
Gene Aliases: PIK3R3, p55, p55-GAMMA, FLJ41892, DKFZp686P05226
Scientific Background: PI3K (p55 gamma) also known as PI3K regulatory subunit 3 (PIK3R3) was first identified by 2-hybrid system as a protein that bind to the intracellular domain of IGF1R. PIK3R3 contains 2 Src homology-2 (SH2) domains, an inter-SH2/p110-binding site and a proline-rich motif. PIK3R3 transcript is detected in all fetal and adult tissues except peripheral blood leukocytes. Expression is low in adult liver and most abundant in adult testis. PIK3R3 can bind IGF1R, INSR, and INSR substrate-1 in vitro and the binding requires receptor activation (1).
References:
1. Dey, B R. et al: Cloning of human p55-gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene 209: 175-183, 1998.
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
The PI3K (p55 gamma) Protein product can be utilized in the following research areas, but not limited to:
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
| Product Type |
Product Name |
Catalog Number |
Application |
Pack Sizes |
| Enzymes |
PI3K (p110 alpha(E545K)/p85 alpha), Active |
P27-15H |
Kinase Assay, Western Blot |
View PI3K (p110 alpha(E545K)/p85 alpha), Active
|
| Enzymes |
PI3K (p110 alpha/p85 alpha), Active |
P27-18H |
Kinase Assay, Western Blot |
View PI3K (p110 alpha/p85 alpha), Active
|
| Enzymes |
PI3K (p110 alpha/p85 alpha), Active |
P27-10H |
Kinase Assay, Western Blot |
View PI3K (p110 alpha/p85 alpha), Active
|
| Enzymes |
PI3K (p110 beta/p85 alpha), Active |
P28-10H |
Kinase Assay, Western Blot |
View PI3K (p110 beta/p85 alpha), Active
|
| Enzymes |
PI3K (p110 beta/p85 beta), Active |
P28-10BH |
Kinase Assay, Western Blot |
View PI3K (p110 beta/p85 beta), Active
|
| Enzymes |
PI3K (p110 delta/p85 alpha), Active |
P30-10H |
Kinase Assay, Western Blot |
View PI3K (p110 delta/p85 alpha), Active
|
| Enzymes |
PI3K (p120 gamma), Active |
P29-10H |
Kinase Assay, Western Blot |
View PI3K (p120 gamma), Active
|
| Enzymes |
PIK3C2G, Active |
P25-11G |
Kinase Assay, Western Blot |
View PIK3C2G, Active
|
| Signaling Proteins |
PI3K (p85 alpha) Protein |
P31-30H |
Kinase Assay, Western Blot |
View PI3K (p85 alpha) Protein
|
| Signaling Proteins |
PI3K (p85 beta) Protein |
P31-30BH |
Kinase Assay, Western Blot |
View PI3K (p85 beta) Protein
|
| Signaling Proteins |
PI3K (p65 alpha) Protein |
P31-31H |
Western Blot |
View PI3K (p65 alpha) Protein
|
| Enzymes |
PI3K (p110 alpha/p55 gamma), Active |
P27-10CH |
Kinase Assay, Western Blot |
View PI3K (p110 alpha/p55 gamma), Active
|