AURORA A Active Enzymes Active Kinases


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AURORA A, Active (A28-18G)
Catalog Number Pack Size Price (USD)  
AURORA A, Active A28-18G-05 5 ug $205   AURORA A, Active Add to Cart
AURORA A, Active A28-18G-10 10 ug $295   AURORA A, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human AURORA A was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_003600
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~72kDa

Gene Aliases: AURKA, AIK, ARK1, AURA, BTAK, STK6, STK7, STK15, AURORA2, MGC34538

Scientific Background: AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2).

References: 
1. Dutertre, S. et al: On the role of aurora-A in centrosome function. Oncogene. 2002 Sep 9;21(40):6175-83.

2. Katayama, H. et al: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec;22(4):451-64.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




AURORA A, Active Research Areas

The AURORA A, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Ser/Thr Kinases



AURORA A, Active Related Products Found: Total 13 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes AURORA A, Active A28-10G Kinase Assay, Western Blot View AURORA A, Active
Enzymes PLK1, Active P41-10H Kinase Assay, Western Blot View PLK1, Active
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Signaling Reagents MBP Protein M42-54G Kinase Assay, Western Blot View MBP Protein
Enzymes AURORA B, Active A31-10G Kinase Assay, Western Blot View AURORA B, Active
Enzymes LOK, Active S29-11G Kinase Assay, Western Blot View LOK, Active
Enzymes AURORA C, Active A33-10G Kinase Assay, Western Blot View AURORA C, Active
Signaling Proteins LATS2, Unactive L02-35G Kinase Assay, Western Blot View LATS2, Unactive
Enzymes STK33, Active S46-10G Kinase Assay, Western Blot View STK33, Active
Signaling Proteins LKB1(STK11) Protein L15-30G Kinase Assay, Western Blot View LKB1(STK11) Protein
Signaling Proteins AURORA A, Unactive A28-14G Kinase Assay, Western Blot View AURORA A, Unactive
Signaling Proteins AURORA B, Unactive A31-14G Kinase Assay, Western Blot View AURORA B, Unactive
Signaling Proteins AURORA C, Unactive A33-14G Kinase Assay, Western Blot View AURORA C, Unactive


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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