Description: Recombinant full-length human MYT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~93 kDa

Gene Aliases: PKMYT1, FLJ20093, DKFZp547K1610

Scientific Background: MYT1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins which binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system(1). The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn(2+), but not other divalent cations (2).

References: 
1. Kim, J. G. et.al: Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J. Neurosci. Res. 50: 272-290, 1997.

2. Kim, J. G. et.al: Novel member of the zinc finger superfamily: a C(2)-HC finger that recognizes a glia-specific gene. Molec. Cell. Biol. 12: 5632-5639, 1992.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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