ASK1 Active Enzymes Active Kinases


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ASK1, Active (M13-11G)

Catalog Number Pack Size Price (USD)  
ASK1, Active M13-11G-05 5 ug $205   ASK1, Active Add to Cart
ASK1, Active M13-11G-10 10 ug $295   ASK1, Active Add to Cart
ASK1, Active M13-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human ASK1(649-946) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 649-946
Genbank Number: NM_005923
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~60 kDa

Gene Aliases: MAP3K5; MEKK5; MAPKKK5

Scientific Background: ASK1, also known as MAPKKK5, activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with tumor necrosis factor-alpha (1). ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation (2).

References
1. Ichijo, H. et al: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94, 1997.

2. Nishitoh, H. et al: ASK1 is essential for JNK/SAPK activation by TRAF2. Molec. Cell 2: 389-395, 1998.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




ASK1, Active Research Areas

The ASK1, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cellular Stress, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases



ASK1, Active Related Products Found: Total 15 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Signaling Proteins JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
Signaling Proteins JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
Signaling Reagents Kinase Assay Buffer I K01-09 Kinase Assay View Kinase Assay Buffer I
Enzymes RIPK2, Active R08-11G Kinase Assay, Western Blot View RIPK2, Active
Signaling Proteins JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Enzymes HIPK1, Active H03-11G Kinase Assay, Western Blot View HIPK1, Active
Signaling Proteins 14-3-3 theta Protein Y84-30G Western Blot View 14-3-3 theta Protein
Enzymes HIPK4, Active H06-10G Kinase Assay, Western Blot View HIPK4, Active
Signaling Proteins 14-3-3 theta Protein Y84-30N Western Blot View 14-3-3 theta Protein
Signaling Proteins TRAF2 Protein T57-30H Western Blot View TRAF2 Protein
Antibodies Anti-ASK1 M13-60M WB View Anti-ASK1
Antibodies Anti-ASK1 M13-60BM WB View Anti-ASK1
Enzymes MEKK6, Active M14-11G Kinase Assay, Western Blot View MEKK6, Active
Signaling Proteins ASK3 Protein New Signaling Proteins M73-31G Western Blot View ASK3 Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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