Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Kinase Assay, Western Blot
: ~53 kDa
: CD221, IGFIR, JTK13, MGC142170, MGC142172
: IGF1R (Insulin-like Growth Factor 1) is a transmembrane tyrosine kinase receptor that is activated by IGF-1 and by the related growth factor IGF-2 (1). IGF1R mediates the effects of IGF-1 and plays an important role in growth and anabolic effects in adults. The IGF1R is implicated in several cancers, most notably breast cancer where it is highly overexpressed and functions as an anti-apoptotic agent by enhancing cell survival. In many instances, the anti-apoptotic properties of IGF1R overexpression allows cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy (2).
1. Yaghmaie F, et al:. "Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction".. Experimental Gerontology, 2007; 42 (1-2): 148-149
2. Jones, H. et al (2004). "Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells". Endocr. Relat. Cancer, 2004 11 (4): 793-814.
||Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The IGF1R, Active product can be utilized in the following research areas, but not limited to:
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cellular Stress, ERK/MAPK Pathway, Metabolic Disorder, Receptor Tyrosine Kinases