MSK2 Active Enzymes Active Kinases


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MSK2, Active (R18-10G)

Catalog Number Pack Size Price (USD)  
MSK2, Active R18-10G-05 5 ug $205   MSK2, Active Add to Cart
MSK2, Active R18-10G-10 10 ug $295   MSK2, Active Add to Cart
MSK2, Active R18-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length mouse MSK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Mouse
Sequence: Full Length
Genbank Number: BC012964
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~114 kDa

Gene Aliases: RPS6KA4; RSK-B; RSKB

Scientific Background: MSK2 or mitogen- and stress-activated protein kinase-2 is a member of the serine/threonine kinases family that contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. MSK2 is also known as ribosomal protein S6 kinase 4 (RPS6KA4) that are activated by the mitogen-activated protein kinases ERK1, ERK2, and p38.

References
1. Deak, M. et.al: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17: 4426-4441, 1998.

2. Pierrat, B. et.al: RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38-alpha mitogen-activated protein kinase (p38-alpha-MAPK). J. Biol. Chem. 273: 29661-29671, 1998.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




MSK2, Active Research Areas

The MSK2, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cellular Stress, Inflammation, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



MSK2, Active Related Products Found: Total 7 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
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Enzymes p70S6Kb, Active R22-10G Kinase Assay, Western Blot View p70S6Kb, Active
Enzymes RSK1, Active R15-10G Kinase Assay, Western Blot View RSK1, Active
Enzymes RSK2, Active R17-10G Kinase Assay, Western Blot View RSK2, Active
Enzymes RSK3, Active R16-10G Kinase Assay, Western Blot View RSK3, Active
Enzymes RSK4, Active R20-10G Kinase Assay, Western Blot View RSK4, Active
Enzymes MSK1, Active R19-10G Kinase Assay, Western Blot View MSK1, Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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