Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Western Blot
: ~45 kDa
: Cu/Zn-SOD, ALS, SOD, ALS1, IPOA, Homodimer
: SOD1 (superoxide dismutase 1) is the major soluble cytoplasmic enzyme responsible for destroying harmful free superoxide radicals in the body thereby providing defence against oxygen free-radical toxicity. Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme and the SOD1 gene maps to chromosome 21q22 (1). Mutations in the SOD1 gene have been implicated to be the cause of familial amyotrophic lateral sclerosis, increased age-related muscle mass loss, early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortned lifespan (2).
1. Sherman, L. et al: Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA. Proc. Nat. Acad. Sci. 80: 5465-5469, 1983.
2. Al-Chalabi, Ammar, Recent advances in amyotrophic lateral sclerosis". Current Opinion in Neurology, 2000, 13 (4): 397–405.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The SOD1 Protein product can be utilized in the following research areas, but not limited to:
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology