Storage, Stability, and Shipping: Store product at –70
oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
Applications: Kinase Assay, Western Blot
Molecular Weight: ~69 kDa
Gene Aliases : MAPK11; SAPK2; p38-2; PRKM11; SAPK2B; p38b; P38b2
Scientific Background: p38-β is a member of the p38 MAP kinase family and is activated by both proinflammatory cytokines and environmental stress (1). The p38-beta is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase (2). Alternatively spliced transcript variants encoding the same protein have been observed.
References:
1. Jiang, Y. et al: Characterization of the structure and function of a new mitogen-activated protein kinase (p38-beta). J. Biol. Chem. 271: 17920-17926, 1996.
2. Stein, B. et al: p38-2, a novel mitogen-activated protein kinase with distinct properties. J. Biol. Chem. 272: 19509-19517, 1997.
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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The p38 beta, Unactive product can be utilized in the following research areas, but not limited to:
Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases
| Product Type |
Product Name |
Catalog Number |
Application |
Pack Sizes |
| Signaling Reagents |
ATF2 Protein |
A10-55G |
Kinase Assay, Western Blot |
View ATF2 Protein
|
| Signaling Proteins |
p38 alpha, Unactive |
M39-14G |
Kinase Assay, Western Blot |
View p38 alpha, Unactive
|
| Signaling Proteins |
p38 alpha, Unactive |
M39-14U |
Kinase Assay, Western Blot |
View p38 alpha, Unactive
|
| Signaling Proteins |
p38 delta, Unactive |
M38-14G |
Kinase Assay, Western Blot |
View p38 delta, Unactive
|
| Signaling Proteins |
p38 gamma, Unactive |
M37-14G |
Kinase Assay, Western Blot |
View p38 gamma, Unactive
|
| Signaling Proteins |
SMAD3 Protein |
S12-30G |
Kinase Assay, Western Blot |
View SMAD3 Protein
|
| Signaling Proteins |
SMAD2 Protein |
S11-30G |
Kinase Assay, Western Blot |
View SMAD2 Protein
|
| Signaling Proteins |
TOPK, Unactive |
T14-14G |
Kinase Assay, Western Blot |
View TOPK, Unactive
|
| Antibodies |
Anti-p38 beta |
M36-63R |
WB |
View Anti-p38 beta
|
| Enzymes |
p38 alpha, Active |
M39-10BG |
Kinase Assay, Western Blot |
View p38 alpha, Active
|
| Enzymes |
p38 beta, Active |
M36-10BG |
Kinase Assay, Western Blot |
View p38 beta, Active
|
| Enzymes |
p38 gamma, Active |
M37-10BG |
Kinase Assay, Western Blot |
View p38 gamma, Active
|
| Enzymes |
p38 delta, Active |
M38-10BG |
Kinase Assay, Western Blot |
View p38 delta, Active
|