p38 delta Active Enzymes Active Kinases


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p38 delta, Active (M38-10BG)
Catalog Number Pack Size Price (USD)  
p38 delta, Active M38-10BG-05 5 ug $205   p38 delta, Active Add to Cart
p38 delta, Active M38-10BG-10 10 ug $295   p38 delta, Active Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human p38δ was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_002754
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~71 kDa

Gene Aliases: SAPK4; PRKM13; MAPK13

Scientific Background: p38δ (SAPK4) is a member of the p38 MAPK family and is activated by chemical and environmental stresses as well as by proinflammatory cytokines. p38δ has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines (1). MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase (2).

References: 
1. Goedert, M. et al: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16: 3563-3571, 1997.

2. Kumar, S. et al: Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun. 1997 Jun 27;235(3):533-8.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




p38 delta, Active Research Areas

The p38 delta, Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



p38 delta, Active Related Products Found: Total 14 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes p38 alpha, Active M39-10BG Kinase Assay, Western Blot View p38 alpha, Active
Enzymes p38 beta, Active M36-10BG Kinase Assay, Western Blot View p38 beta, Active
Enzymes p38 gamma, Active M37-10BG Kinase Assay, Western Blot View p38 gamma, Active
Signaling Proteins p38 alpha, Unactive M39-14G Kinase Assay, Western Blot View p38 alpha, Unactive
Signaling Proteins p38 beta, Unactive M36-14G Kinase Assay, Western Blot View p38 beta, Unactive
Signaling Proteins p38 alpha, Unactive M39-14U Kinase Assay, Western Blot View p38 alpha, Unactive
Signaling Proteins p38 delta, Unactive M38-14G Kinase Assay, Western Blot View p38 delta, Unactive
Signaling Proteins p38 gamma, Unactive M37-14G Kinase Assay, Western Blot View p38 gamma, Unactive
Antibodies Anti-p38 alpha M39-60M WB View Anti-p38 alpha
Antibodies Anti-p38 alpha M39-63R WB View Anti-p38 alpha
Antibodies Anti-p38 beta M36-63R WB View Anti-p38 beta
Antibodies Anti-p38 gamma M37-63R WB View Anti-p38 gamma
Signaling Reagents p38 Substrate P03-58 Kinase Assay View p38 Substrate
Signaling Reagents p38 alpha (K53A), Unactive M39-16H Kinase Assay, Western Blot View p38 alpha (K53A), Unactive


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Extracellular Ligands
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Signaling Proteins
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Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
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Signaling Proteins Cellular Proteins Cellular Proteins
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Discovery Services
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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