BRK Active Enzymes Active Kinases


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BRK, Active (P94-10G)
Catalog Number Pack Size Price (USD)  
BRK, Active P94-10G-05 5 ug $205   BRK, Active Add to Cart
BRK, Active P94-10G-10 10 ug $295   BRK, Active Add to Cart
BRK, Active P94-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human BRK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_005975
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~80 kDa

Gene Aliases : PTK6; FLJ42088

Scientific Background: BRK is a member of the non-receptor tyrosine kinases (PTKs) that contains an amino terminal SH3 and SH2 domain as well as the catalytic domain (1). BRK expression is low or undetectable in normal mammary tissue and benign lesions. However, approximately two-thirds of breast tumors express appreciable levels, and 27% of tumors over express BRK by fivefold or more (2).

References: 
1. Mitchell, PJ. et al: Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. Oncogene. 1994 Aug;9(8):2383-90.

2. Mitchell, PJ. et al: Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk. Oncogene. 1997 Sep 18;15(12):1497-502.Erratum in: Oncogene 1998 Jul 9;17(1):129.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




BRK, Active Research Areas

The BRK, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cytoplasmic Tyrosine Kinases



BRK, Active Related Products Found: Total 12 Related Products
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Enzymes LYN B, Active L13-10G Kinase Assay, Western Blot View LYN B, Active
Enzymes SRC, Active S19-10G Kinase Assay, Western Blot View SRC, Active
Enzymes LCK, Active L03-10G Kinase Assay, Western Blot View LCK, Active
Signaling Reagents Kinase Assay Buffer II K02-09 Kinase Assay View Kinase Assay Buffer II
Enzymes FRK, Active F14-11G Kinase Assay, Western Blot View FRK, Active
Enzymes ZAP70, Active Z02-10G Kinase Assay, Western Blot View ZAP70, Active
Enzymes SRC, Active S19-18G Kinase Assay, Western Blot View SRC, Active
Enzymes LYN A, Active L13-18G Kinase Assay, Western Blot View LYN A, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
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Enzymes Active Kinases Active Kinases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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