FRK Active Enzymes Active Kinases


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FRK, Active (F14-11G)
Catalog Number Pack Size Price (USD)  
FRK, Active F14-11G-05 5 ug $205   FRK, Active Add to Cart
FRK, Active F14-11G-10 10 ug $295   FRK, Active Add to Cart
FRK, Active F14-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human FRK (208-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 208-end
Genbank Number: NM_002031
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~60 kDa

Gene Aliases : GTK; RAK; PTK5

Scientific Background: FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in beta-cells from the pancreas increases the susceptibility of these cells to beta-cell-toxic events (hallmark of Type I diabetes)(2).

References: 
1. Craven, R J. et al: The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res. 1995 Sep 15;55(18):3969-72.

2. Welsh, M. et al: The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Biochem J. 2004 Aug 15;382(Pt 1):261-8.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




FRK, Active Research Areas

The FRK, Active product can be utilized in the following research areas, but not limited to:

Cancer, Cytoplasmic Tyrosine Kinases, Metabolic Disorder



FRK, Active Related Products Found: Total 11 Related Products
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Enzymes LYN B, Active L13-10G Kinase Assay, Western Blot View LYN B, Active
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Enzymes CSK, Active C63-10U Kinase Assay, Western Blot View CSK, Active
Enzymes BMX, Active B07-10G Kinase Assay, Western Blot View BMX, Active
Enzymes LYN A, Active L13-18G Kinase Assay, Western Blot View LYN A, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
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Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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