Cytoplasmic Tyrosine Kinases


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Cytoplasmic Tyrosine Kinases

Cytoplasmic tyrosine kinases are critical conveyers of extracellular signals. As an example, the JAK - STAT pathway is a relatively well characterized signalling cascade that is activated via a plethora of cytokines and growth factors. This pathway is known to play a role in the regulation of cell proliferation, differentiation, chemotaxis and apoptosis and is important for haematopoiesis, and immune development.


The Janus kinase family consists of 4 distinct family members: JAK 1, JAK 2, JAK3 and TYK2. Whereas JAK 1, JAK2 and TYK2 are ubiquitously expressed, the expression of JAK3 is leukocyte specific. Upon receptor engagement, the Janus kinases are brought into close proximity to one another and are activated via trans-phosphorylation. Activation of these kinases results in the subsequent phosphorylation of tyrosine specific moieties on a number of proteins like and the STAT proteins (Signal Transducers and Activators of Transcription). Currently, 7 different members of the STAT family have been identified; STAT 1, 2, 3 , 4, 5a, 5b, and 6 respectively.


Upon phosphorylation on a conserved tyrosine residue located within the C-terminus, the STAT proteins dimerize and subsequently translocate to the nucleus; translocation has been demonstrated to be dependent upon importin a5 and the Ran nuclear import pathway. Within the nucleus, these proteins bind to and either activate or repress specific gene transcripts.


The JAK-STAT pathway is subject to a number of mechanisms that participate to negatively regulate the pathway; these include for example down-regulation of the receptor, dissociation of the JAKs with its receptor, Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of STATs (PIAS) as well as Protein Tyrosine Phosphatases (PTPs) like CD45.


Interestingly, mutations in these kinases have been reported to occur in certain leukemic conditions. For instance, V617F has been demonstrated to render haemopoietic cells more sensitive to growth factor.


Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Activators 8-pCPT-2-O-Me-cAMP-AM R46-905 View 8-pCPT-2-O-Me-cAMP-AM
Kinase Protein AATK Protein A02-35G Western Blot View AATK Protein
siRNA Sets AATK siRNA Set I A02-911 View AATK siRNA Set I
Active Kinase Mutants ABL1 Mutant (E255K), Active A03-12BG Kinase Assay View ABL1 Mutant (E255K), Active
Active Kinase Mutants ABL1 Mutant (E255V), Active A03-12HH Kinase Assay View ABL1 Mutant (E255V), Active
Active Kinase Mutants ABL1 Mutant (F317I), Active A03-12JG Kinase Assay View ABL1 Mutant (F317I), Active
Active Kinase Mutants ABL1 Mutant (F317L), Active A03-12IG Kinase Assay View ABL1 Mutant (F317L), Active
Active Kinase Mutants ABL1 Mutant (G250E), Active A03-12CG Kinase Assay View ABL1 Mutant (G250E), Active
Active Kinase Mutants ABL1 Mutant (H396P), Active A03-12LG Kinase Assay View ABL1 Mutant (H396P), Active
Active Kinase Mutants ABL1 Mutant (M351T), Active A03-12KG Kinase Assay View ABL1 Mutant (M351T), Active
Active Kinase Mutants ABL1 Mutant (Q252H), Active A03-12FG Kinase Assay View ABL1 Mutant (Q252H), Active
Active Kinase Mutants ABL1 Mutant (T315I), Active A03-12DG Kinase Assay View ABL1 Mutant (T315I), Active
Active Kinase Mutants ABL1 Mutant (V299L), Active A03-12MG Kinase Assay View ABL1 Mutant (V299L), Active
Active Kinase Mutants ABL1 Mutant (Y253F), Active A03-12EG Kinase Assay View ABL1 Mutant (Y253F), Active
Active Kinase Mutants ABL1 Mutant (Y253H), Active A03-12GH Kinase Assay View ABL1 Mutant (Y253H), Active
siRNA Sets ABL1 siRNA Set I A03-911 View ABL1 siRNA Set I
Active Kinases ABL1, Active A03-11H Kinase Assay, Western Blot View ABL1, Active
Active Kinases ABL1, Active A03-18H Kinase Assay, Western Blot View ABL1, Active
siRNA Sets ABL2 siRNA Set I A04-911 View ABL2 siRNA Set I
Active Kinases ABL2, Active A04-11H Kinase Assay, Western Blot View ABL2, Active
Peptide Substrates Abltide A02-58 Kinase Assay View Abltide
siRNA Sets ACK siRNA Set I A05-911 View ACK siRNA Set I
Active Kinases ACK, Active A05-11G Kinase Assay, Western Blot View ACK, Active
Kinase Protein ACVR2A Protein A35-35H Western Blot View ACVR2A Protein
siRNA Sets ACVR2A siRNA Set I A35-911 View ACVR2A siRNA Set I
Kinase Protein ACVR2B Protein A36-35G Western Blot View ACVR2B Protein
siRNA Sets ACVR2B siRNA Set I A36-911 View ACVR2B siRNA Set I
Kinase Inhibitors AG-490 J02-901 View AG-490
Primary Antibodies Anti-BTK B10-63R WB, ELISA, ICC, IF View Anti-BTK
Primary Antibodies Anti-c-JUN C05-63R WB View Anti-c-JUN
Primary Antibodies Anti-c-KIT K06-63R ELISA, IHC View Anti-c-KIT
Primary Antibodies Anti-IL-21 I881-463R WB, ELISA, ICC View Anti-IL-21
Isoform Specific Antibodies Anti-JAK2 J02-63R WB View Anti-JAK2
Phospho Specific Antibodies Anti-phospho-c-KIT (Tyr721) K06-65R WB View Anti-phospho-c-KIT (Tyr721)
Phospho Specific Antibodies Anti-phospho-c-KIT (Tyr936) K06-65BR IHC View Anti-phospho-c-KIT (Tyr936)
Phospho Specific Antibodies Anti-phospho-JAK1 (Tyr1022) J01-65R IHC View Anti-phospho-JAK1 (Tyr1022)
Phospho Specific Antibodies Anti-phospho-JAK2 (Tyr1007) J02-65BR IHC View Anti-phospho-JAK2 (Tyr1007)
Phospho Specific Antibodies Anti-phospho-JAK2 (Tyr221) J02-65R IHC View Anti-phospho-JAK2 (Tyr221)
Phospho Specific Antibodies Anti-phospho-Src (Tyr529) S19-65BR WB, IHC View Anti-phospho-Src (Tyr529)
Phospho Specific Antibodies Anti-phospho-ZAP70 (Tyr319) Z02-65R WB View Anti-phospho-ZAP70 (Tyr319)
Primary Antibodies Anti-PYK2 P92-63R WB View Anti-PYK2
Primary Antibodies Anti-SMC1 S19-63R WB View Anti-SMC1
Primary Antibodies Anti-Src S19-63BR WB, IHC View Anti-Src
Primary Antibodies Anti-TBK1 T02-63R WB, ELISA, ICC View Anti-TBK1
Primary Antibodies Anti-TYK2 (JTK1) T21-63R WB, ELISA View Anti-TYK2 (JTK1)
Primary Antibodies Anti-UBA2 (SAE2) U202-63R WB, ELISA, ICC, IF View Anti-UBA2 (SAE2)
Primary Antibodies Anti-UBE2N (UBC13) U231-63R WB, ELISA, IF, IHC View Anti-UBE2N (UBC13)
Primary Antibodies Anti-UBE2V1 (UEV1A) U238-63R WB, ELISA View Anti-UBE2V1 (UEV1A)
Primary Antibodies Anti-UBLE1A (SAE1) U208-63R WB, ELISA View Anti-UBLE1A (SAE1)
Primary Antibodies Anti-VLK V05-163R WB, ELISA, IF, IHC View Anti-VLK
Primary Antibodies Anti-ZAP70 Z02-61M WB View Anti-ZAP70
Primary Antibodies Anti-ZAP70 Z02-63R WB, ELISA View Anti-ZAP70
Kinase Inhibitors Apigenin K10-900C View Apigenin
siRNA Sets BLK siRNA Set I B02-911 View BLK siRNA Set I
Active Kinases BLK, Active B02-10G Kinase Assay, Western Blot View BLK, Active
siRNA Sets BMX siRNA Set I B07-911 View BMX siRNA Set I
Active Kinases BMX, Active B07-10CG Kinase Assay, Western Blot View BMX, Active
Active Kinases BMX, Active B07-10G Kinase Assay, Western Blot View BMX, Active
siRNA Sets BRK siRNA Set I P94-911 View BRK siRNA Set I
Active Kinases BRK, Active P94-10G Kinase Assay, Western Blot View BRK, Active
Active Kinase Mutants BTK Mutant (C481S), Active B10-12CH Kinase Assay, Western Blot View BTK Mutant (C481S), Active
Active Kinase Mutants BTK Mutant (P190K), Active B10-12BH Kinase Assay, Western Blot View BTK Mutant (P190K), Active
siRNA Sets BTK siRNA Set I B10-911 View BTK siRNA Set I
Active Kinases BTK, Active B10-10CG Kinase Assay, Western Blot View BTK, Active
Active Kinases BTK, Active B10-10H Kinase Assay, Western Blot View BTK, Active
Active Kinases c-KIT, Active K06-11G Kinase Assay, Western Blot View c-KIT, Active
Active Kinase Mutants c-MER Mutant (A708S), Active M51-12BG Kinase Assay View c-MER Mutant (A708S), Active
siRNA Sets c-MER siRNA Set I M51-911 View c-MER siRNA Set I
siRNA Sets CSK siRNA Set I C63-911 View CSK siRNA Set I
Active Kinases CSK, Active C63-10G Kinase Assay, Western Blot View CSK, Active
Active Kinases CSK, Active C63-10U Kinase Assay, Western Blot View CSK, Active
Peptide Substrates CSKtide C63-58 Kinase Assay View CSKtide
Kinase Inhibitors Dasatinib S19-901B View Dasatinib
siRNA Sets FAK siRNA Set I P91-911 View FAK siRNA Set I
Active Kinases FAK, Active P91-10G Kinase Assay, Western Blot View FAK, Active
Active Kinases FAK, Active P91-11H Kinase Assay, Western Blot View FAK, Active
siRNA Sets FER siRNA Set I F16-911 View FER siRNA Set I
Active Kinases FER, Active F16-11G Kinase Assay, Western Blot View FER, Active
siRNA Sets FES siRNA Set I F03-911 View FES siRNA Set I
Active Kinases FES, Active F03-10G Kinase Assay, Western Blot View FES, Active
siRNA Sets FGR siRNA Set I F10-911 View FGR siRNA Set I
Active Kinases FGR, Active F10-10G Kinase Assay, Western Blot View FGR, Active
siRNA Sets FMS siRNA Set I C74-911 View FMS siRNA Set I
Active Kinases FMS, Active C74-11G Kinase Assay, Western Blot View FMS, Active
siRNA Sets FRK siRNA Set I F14-911 View FRK siRNA Set I
Active Kinases FRK, Active F14-11G Kinase Assay, Western Blot View FRK, Active
siRNA Sets FYN A siRNA Set I F15-911 View FYN A siRNA Set I
Active Kinases FYN A, Active F15-10G Kinase Assay, Western Blot View FYN A, Active
siRNA Sets FYN C siRNA Set I F15-911B View FYN C siRNA Set I
Unactive Kinases FYN C, Unactive F15-14G Kinase Assay, Western Blot View FYN C, Unactive
Kinase Inhibitors GW2580 C74-901 View GW2580
siRNA Sets HCK siRNA Set I H02-911 View HCK siRNA Set I
Active Kinases HCK, Active H02-11G Kinase Assay, Western Blot View HCK, Active
Ubiquitin Proteins HERC4 Protein H265-31G Western Blot View HERC4 Protein
siRNA Sets HERC4 siRNA Set I H265-911 View HERC4 siRNA Set I
siRNA Sets HPK1 siRNA Set I M23-911 View HPK1 siRNA Set I
Active Kinases HPK1, Active M23-11G Kinase Assay, Western Blot View HPK1, Active
G-Proteins HRAS1 (G12V) Protein R05-32H Western Blot View HRAS1 (G12V) Protein
G-Proteins HRAS1 (Mature form) Protein R05-31H Western Blot View HRAS1 (Mature form) Protein
Active GTPases/ATPases HRAS1 (Mature form), Active R105-310H Enzyme Assay, Western Blot View HRAS1 (Mature form), Active
siRNA Sets HRAS1 siRNA Set I R05-911 View HRAS1 siRNA Set I
siRNA Sets ITK siRNA Set I I13-911 View ITK siRNA Set I
Active Kinases ITK, Active I13-10G Kinase Assay, Western Blot View ITK, Active
Active Kinases ITK, Active I13-11G Kinase Assay, Western Blot View ITK, Active
Kinase Mutant Proteins JAK1 Mutant (d966-989) Protein J01-12DG Kinase Assay View JAK1 Mutant (d966-989) Protein
Kinase Mutant Proteins JAK1 Mutant (E966V) Protein J01-12CG Kinase Assay View JAK1 Mutant (E966V) Protein
Active Kinase Mutants JAK1 Mutant (R724H), Active J01-12BG Kinase Assay View JAK1 Mutant (R724H), Active
Active Kinases JAK1, Active J01-11G Kinase Assay, Western Blot View JAK1, Active
siRNA Sets JAK2 siRNA Set I J02-911 View JAK2 siRNA Set I
Active Kinases JAK2, Active J02-11G Kinase Assay, Western Blot View JAK2, Active
siRNA Sets JAK3 siRNA Set I J03-911 View JAK3 siRNA Set I
Active Kinases JAK3, Active J03-11G Kinase Assay, Western Blot View JAK3, Active
Peptide Substrates JAK3tide J03-58 Kinase Assay View JAK3tide
Kinase Inhibitors K252A K10-900D View K252A
Kinase Inhibitors K252B K10-900E View K252B
siRNA Sets LCK siRNA Set I L03-911 View LCK siRNA Set I
Active Kinases LCK, Active L03-10G Kinase Assay, Western Blot View LCK, Active
Kinase Inhibitors LFM-A13 B10-901 View LFM-A13
siRNA Sets LYN A siRNA Set I L13-911 View LYN A siRNA Set I
Active Kinases LYN A, Active L13-18G Kinase Assay, Western Blot View LYN A, Active
siRNA Sets LYN B siRNA Set I L13-911B View LYN B siRNA Set I
Active Kinases LYN B, Active L13-10G Kinase Assay, Western Blot View LYN B, Active
Active Kinases MATK (CTK), Active M49-10G Kinase Assay, Western Blot View MATK (CTK), Active
Kinase Inhibitors Nilotinib A03-901 View Nilotinib
siRNA Sets PEAK1 siRNA Set I P18-911 View PEAK1 siRNA Set I
Active Kinases PEAK1, Active P18-11G Kinase Assay, Western Blot View PEAK1, Active
Unactive Kinases PEAK1, Unactive P18-14G Kinase Assay, Western Blot View PEAK1, Unactive
Kinase Inhibitors PKC-412 K10-900B View PKC-412
Peptide Substrates Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Kinase Inhibitors PP1 S19-900 View PP1
Kinase Inhibitors PP2 S19-900B View PP2
siRNA Sets PYK2 siRNA Set I P92-911E View PYK2 siRNA Set I
Active Kinases PYK2, Active P92-11H Kinase Assay, Western Blot View PYK2, Active
siRNA Sets SMC1 siRNA Set I S19-911 View SMC1 siRNA Set I
Kinase Inhibitors SP-600125 M33-900 View SP-600125
Kinase Inhibitors Src I1 S19-901 View Src I1
siRNA Sets SRC siRNA Set I S19-911B View SRC siRNA Set I
Peptide Substrates SRC Substrate S30-58 Kinase Assay View SRC Substrate
Active Kinases SRC, Active S19-10G Kinase Assay, Western Blot View SRC, Active
Active Kinases SRC, Active S19-18G Kinase Assay, Western Blot View SRC, Active
siRNA Sets SRMS siRNA Set I S20-911 View SRMS siRNA Set I
Active Kinases SRMS, Active S20-11G Kinase Assay, Western Blot View SRMS, Active
Kinase Inhibitors Staurosporine K10-900 View Staurosporine
Ubiquitin Proteins STUB1 (CHIP) Protein C268-30H Western Blot View STUB1 (CHIP) Protein
siRNA Sets STUB1 (CHIP) siRNA Set I C268-911 View STUB1 (CHIP) siRNA Set I
siRNA Sets STYK1 (NOK) siRNA Set I S53-911B View STYK1 (NOK) siRNA Set I
Kinase Protein STYK1(NOK) Protein S53-35G Western Blot View STYK1(NOK) Protein
siRNA Sets SYK siRNA Set I S52-911B View SYK siRNA Set I
Active Kinases SYK, Active S52-10G Kinase Assay, Western Blot View SYK, Active
siRNA Sets TBK1 siRNA Set I T02-911B View TBK1 siRNA Set I
Active Kinases TBK1, Active T02-10G Kinase Assay, Western Blot View TBK1, Active
siRNA Sets TTK siRNA Set I T20-911 View TTK siRNA Set I
Active Kinases TTK, Active T20-10G Kinase Assay, Western Blot View TTK, Active
siRNA Sets TXK siRNA Set I T19-911 View TXK siRNA Set I
Active Kinases TXK, Active T19-11CG Kinase Assay, Western Blot View TXK, Active
Active Kinases TXK, Active T19-11G Kinase Assay, Western Blot View TXK, Active
siRNA Sets TYK2 (JTK1) siRNA Set I T21-911 View TYK2 (JTK1) siRNA Set I
Active Kinases TYK2 (JTK1), Active T21-11G Kinase Assay, Western Blot View TYK2 (JTK1), Active
Ubiquitin Proteins UBE2B Protein U211-30H Western Blot View UBE2B Protein
Kinase Protein VLK Protein V05-31G Western Blot View VLK Protein
siRNA Sets VLK siRNA Set I V05-911 View VLK siRNA Set I
Kinase Protein WEE1 Protein W01-35G Western Blot View WEE1 Protein
siRNA Sets WEE1 siRNA Set I W01-911 View WEE1 siRNA Set I
Kinase Protein WEE2 Protein W06-30BG Western Blot View WEE2 Protein
Kinase Inhibitors WHI-P131 J03-901 View WHI-P131
Active Kinase Mutants YES1 Mutant (T348I), Active Y01-12BG Kinase Assay View YES1 Mutant (T348I), Active
siRNA Sets YES1 siRNA Set I Y01-911 View YES1 siRNA Set I
Active Kinases YES1, Active Y01-10G Kinase Assay, Western Blot View YES1, Active
Active Kinase Mutants ZAP70 Mutant (Y319F), Active Z02-12BG Kinase Assay, Western Blot View ZAP70 Mutant (Y319F), Active
siRNA Sets ZAP70 siRNA Set I Z02-911 View ZAP70 siRNA Set I
Active Kinases ZAP70, Active Z02-10G Kinase Assay, Western Blot View ZAP70, Active
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Protein AATK Protein A02-35G Western Blot View AATK Protein
siRNA Sets AATK siRNA Set I A02-911 View AATK siRNA Set I
Active Kinase Mutants ABL1 Mutant (E255K), Active A03-12BG Kinase Assay View ABL1 Mutant (E255K), Active
Active Kinase Mutants ABL1 Mutant (E255V), Active A03-12HH Kinase Assay View ABL1 Mutant (E255V), Active
Active Kinase Mutants ABL1 Mutant (F317I), Active A03-12JG Kinase Assay View ABL1 Mutant (F317I), Active
Active Kinase Mutants ABL1 Mutant (F317L), Active A03-12IG Kinase Assay View ABL1 Mutant (F317L), Active
Active Kinase Mutants ABL1 Mutant (G250E), Active A03-12CG Kinase Assay View ABL1 Mutant (G250E), Active
Active Kinase Mutants ABL1 Mutant (H396P), Active A03-12LG Kinase Assay View ABL1 Mutant (H396P), Active
Active Kinase Mutants ABL1 Mutant (M351T), Active A03-12KG Kinase Assay View ABL1 Mutant (M351T), Active
Active Kinase Mutants ABL1 Mutant (Q252H), Active A03-12FG Kinase Assay View ABL1 Mutant (Q252H), Active
Active Kinase Mutants ABL1 Mutant (T315I), Active A03-12DG Kinase Assay View ABL1 Mutant (T315I), Active
Active Kinase Mutants ABL1 Mutant (V299L), Active A03-12MG Kinase Assay View ABL1 Mutant (V299L), Active
Active Kinase Mutants ABL1 Mutant (Y253F), Active A03-12EG Kinase Assay View ABL1 Mutant (Y253F), Active
Active Kinase Mutants ABL1 Mutant (Y253H), Active A03-12GH Kinase Assay View ABL1 Mutant (Y253H), Active
siRNA Sets ABL1 siRNA Set I A03-911 View ABL1 siRNA Set I
Active Kinases ABL1, Active A03-11H Kinase Assay, Western Blot View ABL1, Active
Active Kinases ABL1, Active A03-18H Kinase Assay, Western Blot View ABL1, Active
siRNA Sets ABL2 siRNA Set I A04-911 View ABL2 siRNA Set I
Active Kinases ABL2, Active A04-11H Kinase Assay, Western Blot View ABL2, Active
Peptide Substrates Abltide A02-58 Kinase Assay View Abltide
siRNA Sets ACK siRNA Set I A05-911 View ACK siRNA Set I
Active Kinases ACK, Active A05-11G Kinase Assay, Western Blot View ACK, Active
Kinase Protein ACVR2A Protein A35-35H Western Blot View ACVR2A Protein
siRNA Sets ACVR2A siRNA Set I A35-911 View ACVR2A siRNA Set I
Kinase Protein ACVR2B Protein A36-35G Western Blot View ACVR2B Protein
siRNA Sets ACVR2B siRNA Set I A36-911 View ACVR2B siRNA Set I
Kinase Inhibitors AG-490 J02-901 View AG-490
Primary Antibodies Anti-BTK B10-63R WB, ELISA, ICC, IF View Anti-BTK
Primary Antibodies Anti-c-JUN C05-63R WB View Anti-c-JUN
Primary Antibodies Anti-c-KIT K06-63R ELISA, IHC View Anti-c-KIT
Primary Antibodies Anti-IL-21 I881-463R WB, ELISA, ICC View Anti-IL-21
Isoform Specific Antibodies Anti-JAK2 J02-63R WB View Anti-JAK2
Phospho Specific Antibodies Anti-phospho-c-KIT (Tyr721) K06-65R WB View Anti-phospho-c-KIT (Tyr721)
Phospho Specific Antibodies Anti-phospho-c-KIT (Tyr936) K06-65BR IHC View Anti-phospho-c-KIT (Tyr936)
Phospho Specific Antibodies Anti-phospho-JAK1 (Tyr1022) J01-65R IHC View Anti-phospho-JAK1 (Tyr1022)
Phospho Specific Antibodies Anti-phospho-JAK2 (Tyr1007) J02-65BR IHC View Anti-phospho-JAK2 (Tyr1007)
Phospho Specific Antibodies Anti-phospho-JAK2 (Tyr221) J02-65R IHC View Anti-phospho-JAK2 (Tyr221)
Phospho Specific Antibodies Anti-phospho-Src (Tyr529) S19-65BR WB, IHC View Anti-phospho-Src (Tyr529)
Phospho Specific Antibodies Anti-phospho-ZAP70 (Tyr319) Z02-65R WB View Anti-phospho-ZAP70 (Tyr319)
Primary Antibodies Anti-PYK2 P92-63R WB View Anti-PYK2
Primary Antibodies Anti-SMC1 S19-63R WB View Anti-SMC1
Primary Antibodies Anti-Src S19-63BR WB, IHC View Anti-Src
Primary Antibodies Anti-TBK1 T02-63R WB, ELISA, ICC View Anti-TBK1
Primary Antibodies Anti-TYK2 (JTK1) T21-63R WB, ELISA View Anti-TYK2 (JTK1)
Primary Antibodies Anti-UBA2 (SAE2) U202-63R WB, ELISA, ICC, IF View Anti-UBA2 (SAE2)
Primary Antibodies Anti-UBE2N (UBC13) U231-63R WB, ELISA, IF, IHC View Anti-UBE2N (UBC13)
Primary Antibodies Anti-UBE2V1 (UEV1A) U238-63R WB, ELISA View Anti-UBE2V1 (UEV1A)
Primary Antibodies Anti-UBLE1A (SAE1) U208-63R WB, ELISA View Anti-UBLE1A (SAE1)
Primary Antibodies Anti-VLK V05-163R WB, ELISA, IF, IHC View Anti-VLK
Primary Antibodies Anti-ZAP70 Z02-61M WB View Anti-ZAP70
Primary Antibodies Anti-ZAP70 Z02-63R WB, ELISA View Anti-ZAP70
Kinase Inhibitors Apigenin K10-900C View Apigenin
siRNA Sets BLK siRNA Set I B02-911 View BLK siRNA Set I
Active Kinases BLK, Active B02-10G Kinase Assay, Western Blot View BLK, Active
siRNA Sets BMX siRNA Set I B07-911 View BMX siRNA Set I
Active Kinases BMX, Active B07-10CG Kinase Assay, Western Blot View BMX, Active
Active Kinases BMX, Active B07-10G Kinase Assay, Western Blot View BMX, Active
siRNA Sets BRK siRNA Set I P94-911 View BRK siRNA Set I
Active Kinases BRK, Active P94-10G Kinase Assay, Western Blot View BRK, Active
Active Kinase Mutants BTK Mutant (C481S), Active B10-12CH Kinase Assay, Western Blot View BTK Mutant (C481S), Active
Active Kinase Mutants BTK Mutant (P190K), Active B10-12BH Kinase Assay, Western Blot View BTK Mutant (P190K), Active
siRNA Sets BTK siRNA Set I B10-911 View BTK siRNA Set I
Active Kinases BTK, Active B10-10CG Kinase Assay, Western Blot View BTK, Active
Active Kinases BTK, Active B10-10H Kinase Assay, Western Blot View BTK, Active
Active Kinases c-KIT, Active K06-11G Kinase Assay, Western Blot View c-KIT, Active
Active Kinase Mutants c-MER Mutant (A708S), Active M51-12BG Kinase Assay View c-MER Mutant (A708S), Active
siRNA Sets c-MER siRNA Set I M51-911 View c-MER siRNA Set I
siRNA Sets CSK siRNA Set I C63-911 View CSK siRNA Set I
Active Kinases CSK, Active C63-10G Kinase Assay, Western Blot View CSK, Active
Active Kinases CSK, Active C63-10U Kinase Assay, Western Blot View CSK, Active
Peptide Substrates CSKtide C63-58 Kinase Assay View CSKtide
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Inhibitors Dasatinib S19-901B View Dasatinib
siRNA Sets FAK siRNA Set I P91-911 View FAK siRNA Set I
Active Kinases FAK, Active P91-10G Kinase Assay, Western Blot View FAK, Active
Active Kinases FAK, Active P91-11H Kinase Assay, Western Blot View FAK, Active
siRNA Sets FER siRNA Set I F16-911 View FER siRNA Set I
Active Kinases FER, Active F16-11G Kinase Assay, Western Blot View FER, Active
siRNA Sets FES siRNA Set I F03-911 View FES siRNA Set I
Active Kinases FES, Active F03-10G Kinase Assay, Western Blot View FES, Active
siRNA Sets FGR siRNA Set I F10-911 View FGR siRNA Set I
Active Kinases FGR, Active F10-10G Kinase Assay, Western Blot View FGR, Active
siRNA Sets FMS siRNA Set I C74-911 View FMS siRNA Set I
Active Kinases FMS, Active C74-11G Kinase Assay, Western Blot View FMS, Active
siRNA Sets FRK siRNA Set I F14-911 View FRK siRNA Set I
Active Kinases FRK, Active F14-11G Kinase Assay, Western Blot View FRK, Active
siRNA Sets FYN A siRNA Set I F15-911 View FYN A siRNA Set I
Active Kinases FYN A, Active F15-10G Kinase Assay, Western Blot View FYN A, Active
siRNA Sets FYN C siRNA Set I F15-911B View FYN C siRNA Set I
Unactive Kinases FYN C, Unactive F15-14G Kinase Assay, Western Blot View FYN C, Unactive
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Inhibitors GW2580 C74-901 View GW2580
siRNA Sets HCK siRNA Set I H02-911 View HCK siRNA Set I
Active Kinases HCK, Active H02-11G Kinase Assay, Western Blot View HCK, Active
Ubiquitin Proteins HERC4 Protein H265-31G Western Blot View HERC4 Protein
siRNA Sets HERC4 siRNA Set I H265-911 View HERC4 siRNA Set I
siRNA Sets HPK1 siRNA Set I M23-911 View HPK1 siRNA Set I
Active Kinases HPK1, Active M23-11G Kinase Assay, Western Blot View HPK1, Active
G-Proteins HRAS1 (G12V) Protein R05-32H Western Blot View HRAS1 (G12V) Protein
G-Proteins HRAS1 (Mature form) Protein R05-31H Western Blot View HRAS1 (Mature form) Protein
Active GTPases/ATPases HRAS1 (Mature form), Active R105-310H Enzyme Assay, Western Blot View HRAS1 (Mature form), Active
siRNA Sets HRAS1 siRNA Set I R05-911 View HRAS1 siRNA Set I
siRNA Sets ITK siRNA Set I I13-911 View ITK siRNA Set I
Active Kinases ITK, Active I13-10G Kinase Assay, Western Blot View ITK, Active
Active Kinases ITK, Active I13-11G Kinase Assay, Western Blot View ITK, Active
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Mutant Proteins JAK1 Mutant (d966-989) Protein J01-12DG Kinase Assay View JAK1 Mutant (d966-989) Protein
Kinase Mutant Proteins JAK1 Mutant (E966V) Protein J01-12CG Kinase Assay View JAK1 Mutant (E966V) Protein
Active Kinase Mutants JAK1 Mutant (R724H), Active J01-12BG Kinase Assay View JAK1 Mutant (R724H), Active
Active Kinases JAK1, Active J01-11G Kinase Assay, Western Blot View JAK1, Active
siRNA Sets JAK2 siRNA Set I J02-911 View JAK2 siRNA Set I
Active Kinases JAK2, Active J02-11G Kinase Assay, Western Blot View JAK2, Active
siRNA Sets JAK3 siRNA Set I J03-911 View JAK3 siRNA Set I
Active Kinases JAK3, Active J03-11G Kinase Assay, Western Blot View JAK3, Active
Peptide Substrates JAK3tide J03-58 Kinase Assay View JAK3tide
Kinase Inhibitors K252A K10-900D View K252A
Kinase Inhibitors K252B K10-900E View K252B
siRNA Sets LCK siRNA Set I L03-911 View LCK siRNA Set I
Active Kinases LCK, Active L03-10G Kinase Assay, Western Blot View LCK, Active
Kinase Inhibitors LFM-A13 B10-901 View LFM-A13
siRNA Sets LYN A siRNA Set I L13-911 View LYN A siRNA Set I
Active Kinases LYN A, Active L13-18G Kinase Assay, Western Blot View LYN A, Active
siRNA Sets LYN B siRNA Set I L13-911B View LYN B siRNA Set I
Active Kinases LYN B, Active L13-10G Kinase Assay, Western Blot View LYN B, Active
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases MATK (CTK), Active M49-10G Kinase Assay, Western Blot View MATK (CTK), Active
Kinase Inhibitors Nilotinib A03-901 View Nilotinib
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets PEAK1 siRNA Set I P18-911 View PEAK1 siRNA Set I
Active Kinases PEAK1, Active P18-11G Kinase Assay, Western Blot View PEAK1, Active
Unactive Kinases PEAK1, Unactive P18-14G Kinase Assay, Western Blot View PEAK1, Unactive
Kinase Inhibitors PKC-412 K10-900B View PKC-412
Peptide Substrates Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Kinase Inhibitors PP1 S19-900 View PP1
Kinase Inhibitors PP2 S19-900B View PP2
siRNA Sets PYK2 siRNA Set I P92-911E View PYK2 siRNA Set I
Active Kinases PYK2, Active P92-11H Kinase Assay, Western Blot View PYK2, Active
siRNA Sets SMC1 siRNA Set I S19-911 View SMC1 siRNA Set I
Kinase Inhibitors SP-600125 M33-900 View SP-600125
Kinase Inhibitors Src I1 S19-901 View Src I1
siRNA Sets SRC siRNA Set I S19-911B View SRC siRNA Set I
Peptide Substrates SRC Substrate S30-58 Kinase Assay View SRC Substrate
Active Kinases SRC, Active S19-10G Kinase Assay, Western Blot View SRC, Active
Active Kinases SRC, Active S19-18G Kinase Assay, Western Blot View SRC, Active
siRNA Sets SRMS siRNA Set I S20-911 View SRMS siRNA Set I
Active Kinases SRMS, Active S20-11G Kinase Assay, Western Blot View SRMS, Active
Kinase Inhibitors Staurosporine K10-900 View Staurosporine
Ubiquitin Proteins STUB1 (CHIP) Protein C268-30H Western Blot View STUB1 (CHIP) Protein
siRNA Sets STUB1 (CHIP) siRNA Set I C268-911 View STUB1 (CHIP) siRNA Set I
siRNA Sets STYK1 (NOK) siRNA Set I S53-911B View STYK1 (NOK) siRNA Set I
Kinase Protein STYK1(NOK) Protein S53-35G Western Blot View STYK1(NOK) Protein
siRNA Sets SYK siRNA Set I S52-911B View SYK siRNA Set I
Active Kinases SYK, Active S52-10G Kinase Assay, Western Blot View SYK, Active
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets TBK1 siRNA Set I T02-911B View TBK1 siRNA Set I
Active Kinases TBK1, Active T02-10G Kinase Assay, Western Blot View TBK1, Active
siRNA Sets TTK siRNA Set I T20-911 View TTK siRNA Set I
Active Kinases TTK, Active T20-10G Kinase Assay, Western Blot View TTK, Active
siRNA Sets TXK siRNA Set I T19-911 View TXK siRNA Set I
Active Kinases TXK, Active T19-11CG Kinase Assay, Western Blot View TXK, Active
Active Kinases TXK, Active T19-11G Kinase Assay, Western Blot View TXK, Active
siRNA Sets TYK2 (JTK1) siRNA Set I T21-911 View TYK2 (JTK1) siRNA Set I
Active Kinases TYK2 (JTK1), Active T21-11G Kinase Assay, Western Blot View TYK2 (JTK1), Active
Ubiquitin Proteins UBE2B Protein U211-30H Western Blot View UBE2B Protein
Kinase Protein VLK Protein V05-31G Western Blot View VLK Protein
siRNA Sets VLK siRNA Set I V05-911 View VLK siRNA Set I
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Protein WEE1 Protein W01-35G Western Blot View WEE1 Protein
siRNA Sets WEE1 siRNA Set I W01-911 View WEE1 siRNA Set I
Kinase Protein WEE2 Protein W06-30BG Western Blot View WEE2 Protein
Kinase Inhibitors WHI-P131 J03-901 View WHI-P131
Active Kinase Mutants YES1 Mutant (T348I), Active Y01-12BG Kinase Assay View YES1 Mutant (T348I), Active
siRNA Sets YES1 siRNA Set I Y01-911 View YES1 siRNA Set I
Active Kinases YES1, Active Y01-10G Kinase Assay, Western Blot View YES1, Active
Active Kinase Mutants ZAP70 Mutant (Y319F), Active Z02-12BG Kinase Assay, Western Blot View ZAP70 Mutant (Y319F), Active
siRNA Sets ZAP70 siRNA Set I Z02-911 View ZAP70 siRNA Set I
Active Kinases ZAP70, Active Z02-10G Kinase Assay, Western Blot View ZAP70, Active
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Cytoplasmic Tyrosine Kinases Product Listing Found: Total 171 Products Matching Research Category Cytoplasmic Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Activators 8-pCPT-2-O-Me-cAMP-AM R46-905 View 8-pCPT-2-O-Me-cAMP-AM
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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Lipid Kinases Active Lipid Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Enzymes Active Proteases Active Proteases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Epigenetic Enzyme Activators Epigenetic Enzyme Activators
Biochemical Compounds Epigenetic Enzyme Inhibitors Epigenetic Enzyme Inhibitors
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds Phosphatase Inhibitors Phosphatase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dihydropyrimidinase Dihydropyrimidinase
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Kinase Mutant Proteins Kinase Mutant Proteins
Signaling Proteins Kinase Protein Kinase Protein
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Phospholipase C Proteins Phospholipase C Proteins
Signaling Proteins Superoxide Dismutase Superoxide Dismutase
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Lipid Substrates Lipid Substrates
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selectivity Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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