CDC42 Protein Cell Signaling Reagents G-Proteins


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CDC42 Protein (C08-30G)
Catalog Number Pack Size Price (USD)  
CDC42 Protein C08-30G-20 20 ug $195 CDC42 Protein  40% OFF   CDC42 Protein Add to Cart
CDC42 Protein C08-30G-50 50 ug $395 CDC42 Protein  40% OFF   CDC42 Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human CDC42 was expressed in E. coli cells using a N-dual GST/His tag.
Tag:
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_001791
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~48 kDa

Gene Aliases: G25K, CDC42Hs

Scientific Background: CDC42 is a member of the Rho family of GTPases and is part of cellular pathways fundamental to growth, differentiation and apoptosis (1). Downstream targets for CDC42 include those that regulate the actin cytoskeleton (e.g. WASP) and cellular stress pathways (e.g. PAK) as well as the coatomer protein complex and PAR6. CDC42 is involved in the G(1)-S progression of the cell cycle. CDC42 and its downstream effector mDia3 are involved in bi-orientation and stabilization of spindle microtubules attachment to kinetochores and regulate chromosome alignment and segregation during mitosis (2).

References: 
1. Erickson, J.W. et al: Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol. 2001 Apr;13(2):153-7.

2. Narumyia, S. et al: A new look at Rho GTPases in cell cycle: role in kinetochore-microtubule attachment. Cell Cycle. 2004 Jul;3(7):855-7.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




CDC42 Protein Research Areas

The CDC42 Protein product can be utilized in the following research areas, but not limited to:

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology



CDC42 Protein Related Products Found: Total 9 Related Products
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Enzymes MRCK beta, Active C28-11G Kinase Assay, Western Blot View MRCK beta, Active
Enzymes MRCK alpha, Active C27-11G Kinase Assay, Western Blot View MRCK alpha, Active
Enzymes PAK3, Active P04-10G Kinase Assay, Western Blot View PAK3, Active
Signaling Proteins RAC1 Protein R03-30G Kinase Assay, Western Blot View RAC1 Protein
Enzymes MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
Enzymes MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
Enzymes MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
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Signaling Proteins G-Proteins G-Proteins
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Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
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Antibodies
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Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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