Description: Human active form TGFB3 (301-412) was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Formulation: Recombinant protein stored in 1 X PBS, 10% glycerol.

Storage, Stability, and Shipping: Stored at desiccated below -20^oC. It is stable at 4^oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Cell Assay

Endotoxin Level: Less than 0.1 ng/μg (IEU/μg) of TGF-β3.

Molecular Weight: ~13.2 kDa

Gene Aliases: ARVD; FLJ16571; TGFB3; TGF-b3

Scientific Background: TGFB3 or transforming growth factor, beta 3 is a member of the TGFβ family of proteins that is a ser/thr protein kinase. TGFB3 is involved in embryogenesis and cell differentiation. TGFB3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development (1). TGFB3 function in normal palate and lung morphogenesis and implicates this cytokine in epithelial-mesenchymal interaction (2).

References: 
1. Nawshad, A. et.al: TGF-beta-3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J. Cell Biol. 163: 1291-1301, 2003.

2. Kaartinen, V. et.al: Abnormal lung development and cleft palate in mice lacking TGF-beta-3 indicates defects of epithelial-mesenchymal interaction. Nature Genet. 11: 415-421, 1995.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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