Leptin Cell Signaling Reagents Growth Factors


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Leptin (L833-40N)
Catalog Number Pack Size Price (USD)  
Leptin L833-40N-10 10 ug $45   Leptin Add to Cart
Leptin L833-40N-50 50 ug $145   Leptin Add to Cart
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Bulk Pricing for Leptin

Product Data Sheet(s)




Description: Human active form Leptin (22-167) was expressed in E. coli cells and purified by proprietary chromatographic techniques.
Tag:
Expression System: E.coli
Species: Human
Sequence: 22-167
Genbank Number: NP_000221
   

Formulation: Recombinant protein stored in 1 X PBS, 10% glycerol.

Storage, Stability, and Shipping: Stored at desiccated below -20oC. It is stable at 4oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Cell Assay

Endotoxin Level: Less than 0.1 ng/µg (IEU/µg) of Leptin.

Molecular Weight: ~14.5 kDa

Gene Aliases: OB; OBS; FLJ94114; LEP

Scientific Background: Leptin is a serum protein produced by adipocytes that play a main role in the regulation of body fat. Leptin is a growth factor in colonic epithelial cells and one that may provide a biological explanation for the observed associations between obesity, physical activity, and colon cancer (1). Leptin appears to be able to control the proliferation of both normal and malignant breast epithelial cells and used for normal mammary gland development (2).

References: 
1. Hardwick JC. et.al : Leptin is a growth factor for colonic epithelial cells. Gastroenterology. 2001 Jul;121(1):79-90.

2. X Hu. et.al: Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 2002 Nov 20;94(22):1704-11.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




Leptin Research Areas

The Leptin product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, p38 Pathway





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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
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Signaling Reagents
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Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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