JNK/SAPK Pathway


Home › Products: Research Category - JNK/SAPK Pathway

JNK/SAPK Pathway

JNK/SAPK is a member of the MAPK family which was originally identified as a stress-activated kinase linked to the death response (1). More recently, JNK/SAPK has been shown to have additional cellular functions and play a key role in cell growth, differentiation and survival.


JNK/SAPK is a central component in the JNK/SAPK signaling pathway and a variety of environment stresses, inflammatory cytokines, growth factors and GPCR agonists can activate this target and the pathway (2). A variety of environmental stimuli impact the small GTPases of the Rho family (Rac, Rho and cdc42) in the cell membrane which in turn lead to the activation of membrane proximal protein components such as MEKKs, ASK1, TAK1/AB1 or MLK3. These protein kinases then phosphorylate and activate MKK4/7, which mediates the activation of the JNK/SAPK family members (3). There are three isoforms of JNK/SAPK family; these include: JNK1, JNK2, and JNK3. Activated JNK/SAPK can translocate to the nucleus where it can regulate the activity of multiple transcription factors including c-Jun, ATF-2, SMAD4, p53 and Elk1.


JNK/SAPK dysregulation, as a result of oxidative stress, plays an important role in the increased phosphorylation of cytoskeletal proteins found in Alzheimer's disease (AD) (4). In hippocampal and cortical regions of individuals with severe AD, activated phospho-JNK/SAPK become localized exclusively in association with neurofibrillar alterations including neurofibrillary tangles, senile plaque neurites, neuropil threads and granulovacuolar degeneration structures (GVD), completely overlapping with tau-positive neurofibrillary pathology.


Therefore, targeting the JNK/SAPK signaling pathway may offer an effective therapy for pathological conditions of the CNS (5). Recent genetic evidence and emerging pharmacological data indicate that activated JNK could also be critical in causing diabetes, insulin resistance and obesity (6).


REFERENCES
1. Basu, S. et al: Stress signals for apoptosis: Ceramide and c-Jun kinase. Oncogene. 1998 Dec 24;17(25):3277-85.
2. Nishina, H. et al: Physiological roles of SAPK/JNK signaling pathway. J Biochem (Tokyo). 2004 Aug;136(2):123-6.
3. Wada, T. et al: Stress kinase MKK7: Savior of cell cycle arrest and cellular senescence. Cell Cycle. 2004 May;3(5):577-9.
4. Zhu, X. et al: Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001 Jan;76(2):435-41.
5. Zhang, G. Y. et al : Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants. Expert Opin Investig Drugs. 2005 Nov;14(11):1373-83.
6. Bennett, B. L. et al: JNK: A new therapeutic target for diabetes. Curr Opin Pharmacol. 2003 Aug;3(4):420-5.


JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Primary Antibodies Anti-GSK3 alpha/ beta G09-63R WB View Anti-GSK3 alpha/ beta
Isoform Specific Antibodies Anti-GSK3 beta G09-60M WB View Anti-GSK3 beta
Primary Antibodies Anti-HSF1 H25-63R WB View Anti-HSF1
Isoform Specific Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Isoform Specific Antibodies Anti-JNK2 M34-60M WB, IP View Anti-JNK2
Primary Antibodies Anti-JNK2/3 M34-63R WB View Anti-JNK2/3
Primary Antibodies Anti-p53 P05-63R WB View Anti-p53
Modification Antibodies Anti-Phosphoserine (Anti-pS) S95-65R WB, ELISA, IP, IHC View Anti-Phosphoserine (Anti-pS)
Modification Antibodies Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR WB, ELISA View Anti-Phosphoserine (Anti-pS), Biotin Conjugated
Modification Antibodies Anti-Phosphothreonine (Anti-pT) T95-65R WB, ELISA, IP, IHC View Anti-Phosphothreonine (Anti-pT)
Modification Antibodies Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR WB, ELISA View Anti-Phosphothreonine (Anti-pT), Biotin Conjugated
Modification Antibodies Anti-Phosphotyrosine (Anti-pY) T96-65R WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY)
Modification Antibodies Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated
Isoform Specific Antibodies Anti-SMAD2 S11-63R WB View Anti-SMAD2
Primary Antibodies Anti-TAB1 New Research Category T01-363R WB, ELISA, ICC, IF View Anti-TAB1
Primary Antibodies Anti-TAK1 New Research Category M15-63R WB, ELISA, IF, IHC View Anti-TAK1
Primary Antibodies Anti-TRAF2 New Research Category T57-363BR WB, ELISA, IF, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF2 New Research Category T57-363R WB, ELISA, IHC View Anti-TRAF2
Primary Antibodies Anti-Trail New Research Category T880-63R WB, ELISA, IHC View Anti-Trail
Primary Antibodies Anti-VAV V14-63R WB,IP View Anti-VAV
Active Kinases ASK1, Active M13-11G Kinase Assay, Western Blot View ASK1, Active
Growth Factors BMP-2 B851-40N Cell Assay View BMP-2
Growth Factors BMP-4 B853-40N Cell Assay View BMP-4
Cellular Proteins BMP2K Protein B03-11G Western Blot View BMP2K Protein
Active Kinases BMPR2, Active B06-11H Kinase Assay, Western Blot View BMPR2, Active
Transcription Proteins c-JUN Protein J05-55G Kinase Assay, Western Blot View c-JUN Protein
Active Phosphatases DUSP22 (MKPX), Active D22-20G Phosphatase Assay, Western Blot View DUSP22 (MKPX), Active
Active Kinases GCK, Active M24-10G Kinase Assay, Western Blot View GCK, Active
Active Kinases GLK, Active M25-11G Kinase Assay, Western Blot View GLK, Active
Active Kinases HGK, Active M26-11G Kinase Assay, Western Blot View HGK, Active
Transcription Proteins HSF1 Protein H25-30G Kinase Assay, Western Blot View HSF1 Protein
Growth Factors IL-18 I878-40N Cell Assay View IL-18
Growth Factors IL-2 I862-40N Cell Assay View IL-2
Growth Factors IL-8 (72AA) I868-40N Cell Assay View IL-8 (72AA)
Chemokines IP-10 I838-40N Cell Assay View IP-10
Active Kinases JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Unactive Kinases JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
Active Kinases JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active
Unactive Kinases JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
Active Kinases JNK3, Active M35-10BG Kinase Assay, Western Blot View JNK3, Active
Unactive Kinases JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Growth Factors Leptin L833-40N Cell Assay View Leptin
Active Kinases MEKK1, Active M09-11G Kinase Assay, Western Blot View MEKK1, Active
Active Kinases MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
Active Kinases MEKK3, Active M11-10G Kinase Assay, Western Blot View MEKK3, Active
Active Kinases MEKK6, Active M14-11G Kinase Assay, Western Blot View MEKK6, Active
Active Kinases MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
Active Kinases MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
Active Kinases MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Transcription Proteins NFATC1 Protein N12-30G Western Blot View NFATC1 Protein
Cell Cycle Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p63 Protein P06-30G Kinase Assay, Western Blot View p63 Protein
Cell Cycle Proteins p73 alpha Protein P08-30G Kinase Assay, Western Blot View p73 alpha Protein
Cell Cycle Proteins p73 beta Protein P08-30BG Western Blot View p73 beta Protein
Cell Cycle Proteins p73 gamma Protein P08-30CG Western Blot View p73 gamma Protein
G-Proteins RGS1 Protein R39-30H Western Blot View RGS1 Protein
Cellular Proteins RIPK1 Protein R07-34G Western Blot View RIPK1 Protein
Active Kinases RIPK2, Active R08-11G Kinase Assay, Western Blot View RIPK2, Active
Active Kinases RIPK3, Active R09-10G Kinase Assay, Western Blot View RIPK3, Active
Chemokines SDF-1 S821-40N Cell Assay View SDF-1
Transcription Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
Transcription Proteins SMAD2 Protein S11-30G Kinase Assay, Western Blot View SMAD2 Protein
Transcription Proteins SMAD3 Protein S12-30G Kinase Assay, Western Blot View SMAD3 Protein
Transcription Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
Transcription Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein
Transcription Proteins SMAD9 Protein S17-30G Western Blot View SMAD9 Protein
Active Kinases STK3, Active S24-10G Kinase Assay, Western Blot View STK3, Active
Active Kinases TAK1-TAB1, Active M15-13G Kinase Assay, Western Blot View TAK1-TAB1, Active
Active Kinases TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
Active Kinases TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
Active Kinases TAOK3, Active T26-11G Kinase Assay, Western Blot View TAOK3, Active
Growth Factors TGFB1 T831-40N Cell Assay View TGFB1
Growth Factors TGFB3 T833-40CN Cell Assay View TGFB3
Active Kinases TGFBR1 (ALK5), Active T07-11G Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Peptide Substrates TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
Unactive Kinases TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
Active Kinases TGFBR2, Active T08-11G Kinase Assay, Western Blot View TGFBR2, Active
Cytokines TNF-alpha T860-40N Cell Assay View TNF-alpha
Cytokines TNFB T861-40N Cell Assay View TNFB
Ubiquitin Proteins TP53RK Protein T29-34G Western Blot View TP53RK Protein
Adaptor Proteins TRAF2 Protein T57-30H Western Blot View TRAF2 Protein
Cytokines TRAIL T880-40N Cell Assay View TRAIL
Cellular Proteins VAV1 Protein New Research Category V14-31G Western Blot View VAV1 Protein
Active Kinases VRK1, Active V01-10G Kinase Assay, Western Blot View VRK1, Active
Active Kinases VRK2, Active V02-11G Kinase Assay, Western Blot View VRK2, Active
Cellular Proteins VRK3 Protein V03-30G Western Blot View VRK3 Protein
Active Kinases ZAK, Active Z01-10G Kinase Assay, Western Blot View ZAK, Active
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Primary Antibodies Anti-GSK3 alpha/ beta G09-63R WB View Anti-GSK3 alpha/ beta
Isoform Specific Antibodies Anti-GSK3 beta G09-60M WB View Anti-GSK3 beta
Primary Antibodies Anti-HSF1 H25-63R WB View Anti-HSF1
Isoform Specific Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Isoform Specific Antibodies Anti-JNK2 M34-60M WB, IP View Anti-JNK2
Primary Antibodies Anti-JNK2/3 M34-63R WB View Anti-JNK2/3
Primary Antibodies Anti-p53 P05-63R WB View Anti-p53
Modification Antibodies Anti-Phosphoserine (Anti-pS) S95-65R WB, ELISA, IP, IHC View Anti-Phosphoserine (Anti-pS)
Modification Antibodies Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR WB, ELISA View Anti-Phosphoserine (Anti-pS), Biotin Conjugated
Modification Antibodies Anti-Phosphothreonine (Anti-pT) T95-65R WB, ELISA, IP, IHC View Anti-Phosphothreonine (Anti-pT)
Modification Antibodies Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR WB, ELISA View Anti-Phosphothreonine (Anti-pT), Biotin Conjugated
Modification Antibodies Anti-Phosphotyrosine (Anti-pY) T96-65R WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY)
Modification Antibodies Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated
Isoform Specific Antibodies Anti-SMAD2 S11-63R WB View Anti-SMAD2
Primary Antibodies Anti-TAB1 New Research Category T01-363R WB, ELISA, ICC, IF View Anti-TAB1
Primary Antibodies Anti-TAK1 New Research Category M15-63R WB, ELISA, IF, IHC View Anti-TAK1
Primary Antibodies Anti-TRAF2 New Research Category T57-363BR WB, ELISA, IF, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF2 New Research Category T57-363R WB, ELISA, IHC View Anti-TRAF2
Primary Antibodies Anti-Trail New Research Category T880-63R WB, ELISA, IHC View Anti-Trail
Primary Antibodies Anti-VAV V14-63R WB,IP View Anti-VAV
Active Kinases ASK1, Active M13-11G Kinase Assay, Western Blot View ASK1, Active
Growth Factors BMP-2 B851-40N Cell Assay View BMP-2
Growth Factors BMP-4 B853-40N Cell Assay View BMP-4
Cellular Proteins BMP2K Protein B03-11G Western Blot View BMP2K Protein
Active Kinases BMPR2, Active B06-11H Kinase Assay, Western Blot View BMPR2, Active
Transcription Proteins c-JUN Protein J05-55G Kinase Assay, Western Blot View c-JUN Protein
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Phosphatases DUSP22 (MKPX), Active D22-20G Phosphatase Assay, Western Blot View DUSP22 (MKPX), Active
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases GCK, Active M24-10G Kinase Assay, Western Blot View GCK, Active
Active Kinases GLK, Active M25-11G Kinase Assay, Western Blot View GLK, Active
Active Kinases HGK, Active M26-11G Kinase Assay, Western Blot View HGK, Active
Transcription Proteins HSF1 Protein H25-30G Kinase Assay, Western Blot View HSF1 Protein
Growth Factors IL-18 I878-40N Cell Assay View IL-18
Growth Factors IL-2 I862-40N Cell Assay View IL-2
Growth Factors IL-8 (72AA) I868-40N Cell Assay View IL-8 (72AA)
Chemokines IP-10 I838-40N Cell Assay View IP-10
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Unactive Kinases JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
Active Kinases JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active
Unactive Kinases JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
Active Kinases JNK3, Active M35-10BG Kinase Assay, Western Blot View JNK3, Active
Unactive Kinases JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Growth Factors Leptin L833-40N Cell Assay View Leptin
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases MEKK1, Active M09-11G Kinase Assay, Western Blot View MEKK1, Active
Active Kinases MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
Active Kinases MEKK3, Active M11-10G Kinase Assay, Western Blot View MEKK3, Active
Active Kinases MEKK6, Active M14-11G Kinase Assay, Western Blot View MEKK6, Active
Active Kinases MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
Active Kinases MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
Active Kinases MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Transcription Proteins NFATC1 Protein N12-30G Western Blot View NFATC1 Protein
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Cell Cycle Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p63 Protein P06-30G Kinase Assay, Western Blot View p63 Protein
Cell Cycle Proteins p73 alpha Protein P08-30G Kinase Assay, Western Blot View p73 alpha Protein
Cell Cycle Proteins p73 beta Protein P08-30BG Western Blot View p73 beta Protein
Cell Cycle Proteins p73 gamma Protein P08-30CG Western Blot View p73 gamma Protein
G-Proteins RGS1 Protein R39-30H Western Blot View RGS1 Protein
Cellular Proteins RIPK1 Protein R07-34G Western Blot View RIPK1 Protein
Active Kinases RIPK2, Active R08-11G Kinase Assay, Western Blot View RIPK2, Active
Active Kinases RIPK3, Active R09-10G Kinase Assay, Western Blot View RIPK3, Active
Chemokines SDF-1 S821-40N Cell Assay View SDF-1
Transcription Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
Transcription Proteins SMAD2 Protein S11-30G Kinase Assay, Western Blot View SMAD2 Protein
Transcription Proteins SMAD3 Protein S12-30G Kinase Assay, Western Blot View SMAD3 Protein
Transcription Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
Transcription Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein
Transcription Proteins SMAD9 Protein S17-30G Western Blot View SMAD9 Protein
Active Kinases STK3, Active S24-10G Kinase Assay, Western Blot View STK3, Active
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases TAK1-TAB1, Active M15-13G Kinase Assay, Western Blot View TAK1-TAB1, Active
Active Kinases TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
Active Kinases TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
Active Kinases TAOK3, Active T26-11G Kinase Assay, Western Blot View TAOK3, Active
Growth Factors TGFB1 T831-40N Cell Assay View TGFB1
Growth Factors TGFB3 T833-40CN Cell Assay View TGFB3
Active Kinases TGFBR1 (ALK5), Active T07-11G Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Peptide Substrates TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
Unactive Kinases TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
Active Kinases TGFBR2, Active T08-11G Kinase Assay, Western Blot View TGFBR2, Active
Cytokines TNF-alpha T860-40N Cell Assay View TNF-alpha
Cytokines TNFB T861-40N Cell Assay View TNFB
Ubiquitin Proteins TP53RK Protein T29-34G Western Blot View TP53RK Protein
Adaptor Proteins TRAF2 Protein T57-30H Western Blot View TRAF2 Protein
Cytokines TRAIL T880-40N Cell Assay View TRAIL
Cellular Proteins VAV1 Protein New Research Category V14-31G Western Blot View VAV1 Protein
Active Kinases VRK1, Active V01-10G Kinase Assay, Western Blot View VRK1, Active
Active Kinases VRK2, Active V02-11G Kinase Assay, Western Blot View VRK2, Active
Cellular Proteins VRK3 Protein V03-30G Western Blot View VRK3 Protein
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases ZAK, Active Z01-10G Kinase Assay, Western Blot View ZAK, Active
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
JNK/SAPK Pathway Product Listing Found: Total 91 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Items in Your Cart (0)
Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




Keep in touch, join us on:
JNK/SAPK Pathway   JNK/SAPK Pathway   JNK/SAPK Pathway