JNK/SAPK Pathway


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JNK/SAPK Pathway

JNK/SAPK is a member of the MAPK family which was originally identified as a stress-activated kinase linked to the death response (1). More recently, JNK/SAPK has been shown to have additional cellular functions and play a key role in cell growth, differentiation and survival.


JNK/SAPK is a central component in the JNK/SAPK signaling pathway and a variety of environment stresses, inflammatory cytokines, growth factors and GPCR agonists can activate this target and the pathway (2). A variety of environmental stimuli impact the small GTPases of the Rho family (Rac, Rho and cdc42) in the cell membrane which in turn lead to the activation of membrane proximal protein components such as MEKKs, ASK1, TAK1/AB1 or MLK3. These protein kinases then phosphorylate and activate MKK4/7, which mediates the activation of the JNK/SAPK family members (3). There are three isoforms of JNK/SAPK family; these include: JNK1, JNK2, and JNK3. Activated JNK/SAPK can translocate to the nucleus where it can regulate the activity of multiple transcription factors including c-Jun, ATF-2, SMAD4, p53 and Elk1.


JNK/SAPK dysregulation, as a result of oxidative stress, plays an important role in the increased phosphorylation of cytoskeletal proteins found in Alzheimer's disease (AD) (4). In hippocampal and cortical regions of individuals with severe AD, activated phospho-JNK/SAPK become localized exclusively in association with neurofibrillar alterations including neurofibrillary tangles, senile plaque neurites, neuropil threads and granulovacuolar degeneration structures (GVD), completely overlapping with tau-positive neurofibrillary pathology.


Therefore, targeting the JNK/SAPK signaling pathway may offer an effective therapy for pathological conditions of the CNS (5). Recent genetic evidence and emerging pharmacological data indicate that activated JNK could also be critical in causing diabetes, insulin resistance and obesity (6).


REFERENCES
1. Basu, S. et al: Stress signals for apoptosis: Ceramide and c-Jun kinase. Oncogene. 1998 Dec 24;17(25):3277-85.
2. Nishina, H. et al: Physiological roles of SAPK/JNK signaling pathway. J Biochem (Tokyo). 2004 Aug;136(2):123-6.
3. Wada, T. et al: Stress kinase MKK7: Savior of cell cycle arrest and cellular senescence. Cell Cycle. 2004 May;3(5):577-9.
4. Zhu, X. et al: Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001 Jan;76(2):435-41.
5. Zhang, G. Y. et al : Agents targeting c-Jun N-terminal kinase pathway as potential neuroprotectants. Expert Opin Investig Drugs. 2005 Nov;14(11):1373-83.
6. Bennett, B. L. et al: JNK: A new therapeutic target for diabetes. Curr Opin Pharmacol. 2003 Aug;3(4):420-5.


JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Activators 8-pCPT-2-O-Me-cAMP-AM R46-905 View 8-pCPT-2-O-Me-cAMP-AM
Primary Antibodies Anti-BMPR2 B06-63R WB, ELISA, IHC View Anti-BMPR2
Primary Antibodies Anti-GSK3 alpha/beta G09-63R WB View Anti-GSK3 alpha/beta
Isoform Specific Antibodies Anti-GSK3 beta G09-60M WB View Anti-GSK3 beta
Primary Antibodies Anti-HSF1 H25-63R WB View Anti-HSF1
Isoform Specific Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Isoform Specific Antibodies Anti-JNK2 M34-60M WB, IP View Anti-JNK2
Primary Antibodies Anti-JNK2/3 M34-63R WB View Anti-JNK2/3
Primary Antibodies Anti-p53 P05-63R WB View Anti-p53
Phospho Specific Antibodies Anti-phospho-ASK1 (Ser966) M13-65R IHC View Anti-phospho-ASK1 (Ser966)
Phospho Specific Antibodies Anti-phospho-p53 (Ser392) P05-363R WB View Anti-phospho-p53 (Ser392)
Phospho Specific Antibodies Anti-phospho-PAK1/2/3 (Thr402) P02-652R WB View Anti-phospho-PAK1/2/3 (Thr402)
Modification Antibodies Anti-Phosphoserine (Anti-pS) S95-65R WB, ELISA, IHC, IP View Anti-Phosphoserine (Anti-pS)
Modification Antibodies Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR WB, ELISA View Anti-Phosphoserine (Anti-pS), Biotin Conjugated
Modification Antibodies Anti-Phosphothreonine (Anti-pT) T95-65R WB, ELISA, IHC, IP View Anti-Phosphothreonine (Anti-pT)
Modification Antibodies Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR WB, ELISA View Anti-Phosphothreonine (Anti-pT), Biotin Conjugated
Modification Antibodies Anti-Phosphotyrosine (Anti-pY) T96-65R WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY)
Modification Antibodies Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated
Primary Antibodies Anti-RIPK1 R07-63R WB, ELISA, IF, IHC View Anti-RIPK1
Primary Antibodies Anti-RIPK2 R08-63BR WB, ELISA, ICC, IF View Anti-RIPK2
Primary Antibodies Anti-RIPK2 R08-63R WB, ELISA, ICC View Anti-RIPK2
Primary Antibodies Anti-RIPK3 R09-63R WB, ELISA, IF, IHC View Anti-RIPK3
Isoform Specific Antibodies Anti-SMAD2 S11-63R WB View Anti-SMAD2
Primary Antibodies Anti-TAB1 T01-363R WB, ELISA, ICC, IF View Anti-TAB1
Primary Antibodies Anti-TAK1 M15-63R WB, ELISA, IF, IHC View Anti-TAK1
Primary Antibodies Anti-TRAF2 T57-363BR WB, ELISA, IF, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF2 T57-363R WB, ELISA, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF3 T58-363BR WB, ELISA, ICC View Anti-TRAF3
Primary Antibodies Anti-TRAF3 T58-363R WB, ELISA, IF View Anti-TRAF3
Primary Antibodies Anti-Trail T880-63R WB, ELISA, IHC View Anti-Trail
Primary Antibodies Anti-VAV V14-63R WB, IP View Anti-VAV
Kinase Inhibitors Apigenin K10-900C View Apigenin
siRNA Sets ASK1 siRNA Set I M13-911 View ASK1 siRNA Set I
Active Kinases ASK1, Active M13-11G Kinase Assay, Western Blot View ASK1, Active
Kinase Protein ASK3 Protein M73-31G Western Blot View ASK3 Protein
Cellular Proteins AXIN1 Protein A71-30G Western Blot View AXIN1 Protein
Cellular Proteins AXIN2 Protein A72-30G Western Blot View AXIN2 Protein
Growth Factors BMP-2 B851-40N Cell Assay View BMP-2
siRNA Sets BMP-2 siRNA Set I B851-911 View BMP-2 siRNA Set I
Growth Factors BMP-4 B853-40N Cell Assay View BMP-4
siRNA Sets BMP-4 siRNA Set I B853-911 View BMP-4 siRNA Set I
Kinase Protein BMP2K Protein B03-11G Western Blot View BMP2K Protein
siRNA Sets BMP2K siRNA Set I B03-911B View BMP2K siRNA Set I
siRNA Sets BMPR2 siRNA Set I B06-911 View BMPR2 siRNA Set I
Active Kinases BMPR2, Active B06-11H Kinase Assay, Western Blot View BMPR2, Active
Transcription Proteins c-JUN Protein J05-55G Kinase Assay, Western Blot View c-JUN Protein
siRNA Sets c-Jun siRNA Set I J05-911 View c-Jun siRNA Set I
Active Phosphatases DUSP22 (MKPX), Active D22-20G Phosphatase Assay, Western Blot View DUSP22 (MKPX), Active
siRNA Sets DUSP22 siRNA Set I D22-911 View DUSP22 siRNA Set I
siRNA Sets GCK siRNA Set I M24-911 View GCK siRNA Set I
Active Kinases GCK, Active M24-10G Kinase Assay, Western Blot View GCK, Active
siRNA Sets GLK siRNA Set I M25-911 View GLK siRNA Set I
Active Kinases GLK, Active M25-11G Kinase Assay, Western Blot View GLK, Active
siRNA Sets HGK siRNA Set I M26-911 View HGK siRNA Set I
Active Kinases HGK, Active M26-11G Kinase Assay, Western Blot View HGK, Active
Transcription Proteins HSF1 Protein H25-30G Kinase Assay, Western Blot View HSF1 Protein
siRNA Sets HSF1 siRNA Set I H25-911 View HSF1 siRNA Set I
siRNA Sets IL-18 siRNA Set I I878-911 View IL-18 siRNA Set I
Growth Factors IL-2 I862-40N Cell Assay View IL-2
siRNA Sets IL-2 siRNA Set I I862-911 View IL-2 siRNA Set I
Growth Factors IL-8 (72AA) I868-40N Cell Assay View IL-8 (72AA)
siRNA Sets IL-8 (72AA) siRNA Set I I868-911 View IL-8 (72AA) siRNA Set I
Chemokines IP-10 I838-40N Cell Assay View IP-10
siRNA Sets IP-10 siRNA Set I I838-911 View IP-10 siRNA Set I
siRNA Sets JNK1 siRNA Set I M33-911 View JNK1 siRNA Set I
Active Kinases JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Unactive Kinases JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
siRNA Sets JNK2 siRNA Set I M34-911 View JNK2 siRNA Set I
Active Kinases JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active
Unactive Kinases JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
siRNA Sets JNK3 siRNA Set I M35-911 View JNK3 siRNA Set I
Active Kinases JNK3, Active M35-10BG Kinase Assay, Western Blot View JNK3, Active
Unactive Kinases JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Kinase Inhibitors K252A K10-900D View K252A
Kinase Inhibitors K252B K10-900E View K252B
Growth Factors Leptin L833-40N Cell Assay View Leptin
siRNA Sets Leptin siRNA Set I L833-911 View Leptin siRNA Set I
siRNA Sets MEKK1 siRNA Set I M09-911 View MEKK1 siRNA Set I
Active Kinases MEKK1, Active M09-11G Kinase Assay, Western Blot View MEKK1, Active
siRNA Sets MEKK2 siRNA Set I M10-911 View MEKK2 siRNA Set I
Active Kinases MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
siRNA Sets MEKK3 siRNA Set I M11-911 View MEKK3 siRNA Set I
Active Kinases MEKK3, Active M11-10G Kinase Assay, Western Blot View MEKK3, Active
siRNA Sets MEKK6 siRNA Set I M14-911 View MEKK6 siRNA Set I
Active Kinases MEKK6, Active M14-11G Kinase Assay, Western Blot View MEKK6, Active
siRNA Sets MLK1 siRNA Set I M17-911 View MLK1 siRNA Set I
Active Kinases MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
siRNA Sets MLK2 siRNA Set I M18-911 View MLK2 siRNA Set I
Active Kinases MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
siRNA Sets MLK3 siRNA Set I M19-911 View MLK3 siRNA Set I
Active Kinases MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active
siRNA Sets MLK4 siRNA Set I M48-911 View MLK4 siRNA Set I
Active Kinases MLK4, Active M48-11G Kinase Assay, Western Blot View MLK4, Active
siRNA Sets MST1 siRNA Set I S25-911 View MST1 siRNA Set I
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
siRNA Sets MST3 siRNA Set I S42-911 View MST3 siRNA Set I
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
siRNA Sets MST4 siRNA Set I M59-911 View MST4 siRNA Set I
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Kinase Inhibitors Necrostatin-1 R07-901 View Necrostatin-1
Transcription Proteins NFATC1 Protein N12-30G Western Blot View NFATC1 Protein
siRNA Sets NFATC1 siRNA Set I N12-911 View NFATC1 siRNA Set I
Kinase Protein NRBP1 Protein N24-34G Western Blot View NRBP1 Protein
siRNA Sets p38 alpha siRNA Set I M39-911 View p38 alpha siRNA Set I
siRNA Sets p38 beta siRNA Set I M36-911 View p38 beta siRNA Set I
siRNA Sets p38 delta siRNA Set I M38-911 View p38 delta siRNA Set I
siRNA Sets p38gamma siRNA Set I M37-911 View p38gamma siRNA Set I
Cell Cycle Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
siRNA Sets p53 siRNA Set I P05-911 View p53 siRNA Set I
Cell Cycle Proteins p63 Protein P06-30G Kinase Assay, Western Blot View p63 Protein
siRNA Sets p63 siRNA Set I P06-911B View p63 siRNA Set I
Cell Cycle Proteins p73 alpha Protein P08-30G Kinase Assay, Western Blot View p73 alpha Protein
Cell Cycle Proteins p73 beta Protein P08-30BG Western Blot View p73 beta Protein
Cell Cycle Proteins p73 gamma Protein P08-30CG Western Blot View p73 gamma Protein
siRNA Sets p73alpha siRNA Set I P08-911 View p73alpha siRNA Set I
siRNA Sets p73beta siRNA Set I P08-911B View p73beta siRNA Set I
siRNA Sets p73gamma siRNA Set I P08-911C View p73gamma siRNA Set I
Kinase Inhibitors Piceatannol I01-901 View Piceatannol
Kinase Inhibitors PKC-412 K10-900B View PKC-412
G-Proteins RGS1 Protein R39-30H Western Blot View RGS1 Protein
siRNA Sets RGS1 siRNA Set I R39-911 View RGS1 siRNA Set I
siRNA Sets RIPK1 siRNA Set I R07-911 View RIPK1 siRNA Set I
Active Kinases RIPK1, Active R07-10G Kinase Assay, Western Blot View RIPK1, Active
Active Kinases RIPK1, Active R07-11G Kinase Assay, Western Blot View RIPK1, Active
siRNA Sets RIPK2 siRNA Set I R08-911 View RIPK2 siRNA Set I
Active Kinases RIPK2, Active R08-11G Kinase Assay, Western Blot View RIPK2, Active
siRNA Sets RIPK3 siRNA Set I R09-911 View RIPK3 siRNA Set I
Active Kinases RIPK3, Active R09-10G Kinase Assay, Western Blot View RIPK3, Active
Kinase Protein RIPK4 Protein R26-35G Kinase Assay View RIPK4 Protein
siRNA Sets RIPK5 siRNA Set I R27-911 View RIPK5 siRNA Set I
Active Kinases RIPK5, Active R27-10G Kinase Assay, Western Blot View RIPK5, Active
Chemokines SDF-1 S821-40N Cell Assay View SDF-1
siRNA Sets SDF-1 siRNA Set I S821-911 View SDF-1 siRNA Set I
Transcription Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
siRNA Sets SMAD1 siRNA Set I S10-911 View SMAD1 siRNA Set I
Transcription Proteins SMAD2 (del SXS) Protein S11-31G Western Blot View SMAD2 (del SXS) Protein
Transcription Proteins SMAD2 Protein S11-30G Kinase Assay, Western Blot View SMAD2 Protein
siRNA Sets SMAD2 siRNA Set I S11-911B View SMAD2 siRNA Set I
Transcription Proteins SMAD3 (del SXS) Protein S12-31G Western Blot View SMAD3 (del SXS) Protein
Transcription Proteins SMAD3 Protein S12-30G Kinase Assay, Western Blot View SMAD3 Protein
siRNA Sets SMAD3 siRNA Set I S12-911B View SMAD3 siRNA Set I
Transcription Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
siRNA Sets SMAD4 siRNA Set I S13-911 View SMAD4 siRNA Set I
Transcription Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein
siRNA Sets SMAD5 siRNA Set I S14-911B View SMAD5 siRNA Set I
Transcription Proteins SMAD9 Protein S17-30G Western Blot View SMAD9 Protein
siRNA Sets SMAD9 siRNA Set I S17-911 View SMAD9 siRNA Set I
Kinase Inhibitors Staurosporine K10-900 View Staurosporine
siRNA Sets STK3 siRNA Set I S24-911 View STK3 siRNA Set I
Active Kinases STK3, Active S24-10G Kinase Assay, Western Blot View STK3, Active
siRNA Sets TAB1 siRNA Set I T01-911 View TAB1 siRNA Set I
siRNA Sets TAK1 siRNA Set I M15-911 View TAK1 siRNA Set I
Active Kinases TAK1-TAB1, Active M15-13G Kinase Assay, Western Blot View TAK1-TAB1, Active
siRNA Sets TAOK1 siRNA Set I T24-911 View TAOK1 siRNA Set I
Active Kinases TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
siRNA Sets TAOK2 siRNA Set I T25-911 View TAOK2 siRNA Set I
Active Kinases TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
siRNA Sets TAOK3 siRNA Set I T26-911 View TAOK3 siRNA Set I
Active Kinases TAOK3, Active T26-11G Kinase Assay, Western Blot View TAOK3, Active
Growth Factors TGFB1 T831-40N Cell Assay View TGFB1
siRNA Sets TGFB1 siRNA Set I T831-911 View TGFB1 siRNA Set I
Growth Factors TGFB3 T833-40CN Cell Assay View TGFB3
siRNA Sets TGFB3 siRNA Set I T833-911 View TGFB3 siRNA Set I
Active Kinases TGFBR1 (ALK5), Active T07-11BG Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Active Kinases TGFBR1 (ALK5), Active T07-11G Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Active Kinase Mutants TGFBR1 Mutant (T204D), Active T07-13G Kinase Assay View TGFBR1 Mutant (T204D), Active
Peptide Substrates TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
siRNA Sets TGFBR1 siRNA Set I T07-911B View TGFBR1 siRNA Set I
Unactive Kinases TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
siRNA Sets TGFBR2 siRNA Set I T08-911B View TGFBR2 siRNA Set I
Active Kinases TGFBR2, Active T08-11BG Kinase Assay, Western Blot View TGFBR2, Active
Active Kinases TGFBR2, Active T08-11G Kinase Assay, Western Blot View TGFBR2, Active
Cytokines TNF-alpha T860-40N Cell Assay View TNF-alpha
siRNA Sets TNF-alpha siRNA Set I T860-911 View TNF-alpha siRNA Set I
Cytokines TNFB T861-40N Cell Assay View TNFB
siRNA Sets TNFB siRNA Set I T861-911 View TNFB siRNA Set I
Kinase Protein TP53RK Protein T29-34G Western Blot View TP53RK Protein
siRNA Sets TP53RK siRNA Set I T29-911 View TP53RK siRNA Set I
Adaptor Proteins TRAF1 Protein T56-30G Western Blot View TRAF1 Protein
Adaptor Proteins TRAF2 Protein T57-30G Western Blot View TRAF2 Protein
siRNA Sets TRAF2 siRNA Set I T57-911 View TRAF2 siRNA Set I
siRNA Sets TRAF3 siRNA Set I T58-911 View TRAF3 siRNA Set I
Cytokines TRAIL T880-40N Cell Assay View TRAIL
siRNA Sets TRAIL siRNA Set I T880-911 View TRAIL siRNA Set I
Cellular Proteins VAV1 Protein V14-31G Western Blot View VAV1 Protein
siRNA Sets VAV1 siRNA Set I V14-911 View VAV1 siRNA Set I
siRNA Sets VRK1 siRNA Set I V01-911 View VRK1 siRNA Set I
Active Kinases VRK1, Active V01-10G Kinase Assay, Western Blot View VRK1, Active
siRNA Sets VRK2 siRNA Set I V02-911 View VRK2 siRNA Set I
Active Kinases VRK2, Active V02-11G Kinase Assay, Western Blot View VRK2, Active
Kinase Protein VRK3 Protein V03-30G Western Blot View VRK3 Protein
siRNA Sets VRK3 siRNA Set I V03-911 View VRK3 siRNA Set I
siRNA Sets ZAK siRNA Set I Z01-911 View ZAK siRNA Set I
Active Kinases ZAK, Active Z01-10G Kinase Assay, Western Blot View ZAK, Active
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Primary Antibodies Anti-BMPR2 B06-63R WB, ELISA, IHC View Anti-BMPR2
Primary Antibodies Anti-GSK3 alpha/beta G09-63R WB View Anti-GSK3 alpha/beta
Isoform Specific Antibodies Anti-GSK3 beta G09-60M WB View Anti-GSK3 beta
Primary Antibodies Anti-HSF1 H25-63R WB View Anti-HSF1
Isoform Specific Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Isoform Specific Antibodies Anti-JNK2 M34-60M WB, IP View Anti-JNK2
Primary Antibodies Anti-JNK2/3 M34-63R WB View Anti-JNK2/3
Primary Antibodies Anti-p53 P05-63R WB View Anti-p53
Phospho Specific Antibodies Anti-phospho-ASK1 (Ser966) M13-65R IHC View Anti-phospho-ASK1 (Ser966)
Phospho Specific Antibodies Anti-phospho-p53 (Ser392) P05-363R WB View Anti-phospho-p53 (Ser392)
Phospho Specific Antibodies Anti-phospho-PAK1/2/3 (Thr402) P02-652R WB View Anti-phospho-PAK1/2/3 (Thr402)
Modification Antibodies Anti-Phosphoserine (Anti-pS) S95-65R WB, ELISA, IHC, IP View Anti-Phosphoserine (Anti-pS)
Modification Antibodies Anti-Phosphoserine (Anti-pS), Biotin Conjugated S95-65BR WB, ELISA View Anti-Phosphoserine (Anti-pS), Biotin Conjugated
Modification Antibodies Anti-Phosphothreonine (Anti-pT) T95-65R WB, ELISA, IHC, IP View Anti-Phosphothreonine (Anti-pT)
Modification Antibodies Anti-Phosphothreonine (Anti-pT), Biotin Conjugated T95-65BR WB, ELISA View Anti-Phosphothreonine (Anti-pT), Biotin Conjugated
Modification Antibodies Anti-Phosphotyrosine (Anti-pY) T96-65R WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY)
Modification Antibodies Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated T96-65BR WB, ELISA, IHC, IP View Anti-Phosphotyrosine (Anti-pY), Biotin Conjugated
Primary Antibodies Anti-RIPK1 R07-63R WB, ELISA, IF, IHC View Anti-RIPK1
Primary Antibodies Anti-RIPK2 R08-63BR WB, ELISA, ICC, IF View Anti-RIPK2
Primary Antibodies Anti-RIPK2 R08-63R WB, ELISA, ICC View Anti-RIPK2
Primary Antibodies Anti-RIPK3 R09-63R WB, ELISA, IF, IHC View Anti-RIPK3
Isoform Specific Antibodies Anti-SMAD2 S11-63R WB View Anti-SMAD2
Primary Antibodies Anti-TAB1 T01-363R WB, ELISA, ICC, IF View Anti-TAB1
Primary Antibodies Anti-TAK1 M15-63R WB, ELISA, IF, IHC View Anti-TAK1
Primary Antibodies Anti-TRAF2 T57-363BR WB, ELISA, IF, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF2 T57-363R WB, ELISA, IHC View Anti-TRAF2
Primary Antibodies Anti-TRAF3 T58-363BR WB, ELISA, ICC View Anti-TRAF3
Primary Antibodies Anti-TRAF3 T58-363R WB, ELISA, IF View Anti-TRAF3
Primary Antibodies Anti-Trail T880-63R WB, ELISA, IHC View Anti-Trail
Primary Antibodies Anti-VAV V14-63R WB, IP View Anti-VAV
Kinase Inhibitors Apigenin K10-900C View Apigenin
siRNA Sets ASK1 siRNA Set I M13-911 View ASK1 siRNA Set I
Active Kinases ASK1, Active M13-11G Kinase Assay, Western Blot View ASK1, Active
Kinase Protein ASK3 Protein M73-31G Western Blot View ASK3 Protein
Cellular Proteins AXIN1 Protein A71-30G Western Blot View AXIN1 Protein
Cellular Proteins AXIN2 Protein A72-30G Western Blot View AXIN2 Protein
Growth Factors BMP-2 B851-40N Cell Assay View BMP-2
siRNA Sets BMP-2 siRNA Set I B851-911 View BMP-2 siRNA Set I
Growth Factors BMP-4 B853-40N Cell Assay View BMP-4
siRNA Sets BMP-4 siRNA Set I B853-911 View BMP-4 siRNA Set I
Kinase Protein BMP2K Protein B03-11G Western Blot View BMP2K Protein
siRNA Sets BMP2K siRNA Set I B03-911B View BMP2K siRNA Set I
siRNA Sets BMPR2 siRNA Set I B06-911 View BMPR2 siRNA Set I
Active Kinases BMPR2, Active B06-11H Kinase Assay, Western Blot View BMPR2, Active
Transcription Proteins c-JUN Protein J05-55G Kinase Assay, Western Blot View c-JUN Protein
siRNA Sets c-Jun siRNA Set I J05-911 View c-Jun siRNA Set I
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Active Phosphatases DUSP22 (MKPX), Active D22-20G Phosphatase Assay, Western Blot View DUSP22 (MKPX), Active
siRNA Sets DUSP22 siRNA Set I D22-911 View DUSP22 siRNA Set I
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets GCK siRNA Set I M24-911 View GCK siRNA Set I
Active Kinases GCK, Active M24-10G Kinase Assay, Western Blot View GCK, Active
siRNA Sets GLK siRNA Set I M25-911 View GLK siRNA Set I
Active Kinases GLK, Active M25-11G Kinase Assay, Western Blot View GLK, Active
siRNA Sets HGK siRNA Set I M26-911 View HGK siRNA Set I
Active Kinases HGK, Active M26-11G Kinase Assay, Western Blot View HGK, Active
Transcription Proteins HSF1 Protein H25-30G Kinase Assay, Western Blot View HSF1 Protein
siRNA Sets HSF1 siRNA Set I H25-911 View HSF1 siRNA Set I
siRNA Sets IL-18 siRNA Set I I878-911 View IL-18 siRNA Set I
Growth Factors IL-2 I862-40N Cell Assay View IL-2
siRNA Sets IL-2 siRNA Set I I862-911 View IL-2 siRNA Set I
Growth Factors IL-8 (72AA) I868-40N Cell Assay View IL-8 (72AA)
siRNA Sets IL-8 (72AA) siRNA Set I I868-911 View IL-8 (72AA) siRNA Set I
Chemokines IP-10 I838-40N Cell Assay View IP-10
siRNA Sets IP-10 siRNA Set I I838-911 View IP-10 siRNA Set I
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets JNK1 siRNA Set I M33-911 View JNK1 siRNA Set I
Active Kinases JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Unactive Kinases JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
siRNA Sets JNK2 siRNA Set I M34-911 View JNK2 siRNA Set I
Active Kinases JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active
Unactive Kinases JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
siRNA Sets JNK3 siRNA Set I M35-911 View JNK3 siRNA Set I
Active Kinases JNK3, Active M35-10BG Kinase Assay, Western Blot View JNK3, Active
Unactive Kinases JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Kinase Inhibitors K252A K10-900D View K252A
Kinase Inhibitors K252B K10-900E View K252B
Growth Factors Leptin L833-40N Cell Assay View Leptin
siRNA Sets Leptin siRNA Set I L833-911 View Leptin siRNA Set I
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets MEKK1 siRNA Set I M09-911 View MEKK1 siRNA Set I
Active Kinases MEKK1, Active M09-11G Kinase Assay, Western Blot View MEKK1, Active
siRNA Sets MEKK2 siRNA Set I M10-911 View MEKK2 siRNA Set I
Active Kinases MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
siRNA Sets MEKK3 siRNA Set I M11-911 View MEKK3 siRNA Set I
Active Kinases MEKK3, Active M11-10G Kinase Assay, Western Blot View MEKK3, Active
siRNA Sets MEKK6 siRNA Set I M14-911 View MEKK6 siRNA Set I
Active Kinases MEKK6, Active M14-11G Kinase Assay, Western Blot View MEKK6, Active
siRNA Sets MLK1 siRNA Set I M17-911 View MLK1 siRNA Set I
Active Kinases MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
siRNA Sets MLK2 siRNA Set I M18-911 View MLK2 siRNA Set I
Active Kinases MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
siRNA Sets MLK3 siRNA Set I M19-911 View MLK3 siRNA Set I
Active Kinases MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active
siRNA Sets MLK4 siRNA Set I M48-911 View MLK4 siRNA Set I
Active Kinases MLK4, Active M48-11G Kinase Assay, Western Blot View MLK4, Active
siRNA Sets MST1 siRNA Set I S25-911 View MST1 siRNA Set I
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
siRNA Sets MST3 siRNA Set I S42-911 View MST3 siRNA Set I
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
siRNA Sets MST4 siRNA Set I M59-911 View MST4 siRNA Set I
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Kinase Inhibitors Necrostatin-1 R07-901 View Necrostatin-1
Transcription Proteins NFATC1 Protein N12-30G Western Blot View NFATC1 Protein
siRNA Sets NFATC1 siRNA Set I N12-911 View NFATC1 siRNA Set I
Kinase Protein NRBP1 Protein N24-34G Western Blot View NRBP1 Protein
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets p38 alpha siRNA Set I M39-911 View p38 alpha siRNA Set I
siRNA Sets p38 beta siRNA Set I M36-911 View p38 beta siRNA Set I
siRNA Sets p38 delta siRNA Set I M38-911 View p38 delta siRNA Set I
siRNA Sets p38gamma siRNA Set I M37-911 View p38gamma siRNA Set I
Cell Cycle Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Cell Cycle Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
siRNA Sets p53 siRNA Set I P05-911 View p53 siRNA Set I
Cell Cycle Proteins p63 Protein P06-30G Kinase Assay, Western Blot View p63 Protein
siRNA Sets p63 siRNA Set I P06-911B View p63 siRNA Set I
Cell Cycle Proteins p73 alpha Protein P08-30G Kinase Assay, Western Blot View p73 alpha Protein
Cell Cycle Proteins p73 beta Protein P08-30BG Western Blot View p73 beta Protein
Cell Cycle Proteins p73 gamma Protein P08-30CG Western Blot View p73 gamma Protein
siRNA Sets p73alpha siRNA Set I P08-911 View p73alpha siRNA Set I
siRNA Sets p73beta siRNA Set I P08-911B View p73beta siRNA Set I
siRNA Sets p73gamma siRNA Set I P08-911C View p73gamma siRNA Set I
Kinase Inhibitors Piceatannol I01-901 View Piceatannol
Kinase Inhibitors PKC-412 K10-900B View PKC-412
G-Proteins RGS1 Protein R39-30H Western Blot View RGS1 Protein
siRNA Sets RGS1 siRNA Set I R39-911 View RGS1 siRNA Set I
siRNA Sets RIPK1 siRNA Set I R07-911 View RIPK1 siRNA Set I
Active Kinases RIPK1, Active R07-10G Kinase Assay, Western Blot View RIPK1, Active
Active Kinases RIPK1, Active R07-11G Kinase Assay, Western Blot View RIPK1, Active
siRNA Sets RIPK2 siRNA Set I R08-911 View RIPK2 siRNA Set I
Active Kinases RIPK2, Active R08-11G Kinase Assay, Western Blot View RIPK2, Active
siRNA Sets RIPK3 siRNA Set I R09-911 View RIPK3 siRNA Set I
Active Kinases RIPK3, Active R09-10G Kinase Assay, Western Blot View RIPK3, Active
Kinase Protein RIPK4 Protein R26-35G Kinase Assay View RIPK4 Protein
siRNA Sets RIPK5 siRNA Set I R27-911 View RIPK5 siRNA Set I
Active Kinases RIPK5, Active R27-10G Kinase Assay, Western Blot View RIPK5, Active
Chemokines SDF-1 S821-40N Cell Assay View SDF-1
siRNA Sets SDF-1 siRNA Set I S821-911 View SDF-1 siRNA Set I
Transcription Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
siRNA Sets SMAD1 siRNA Set I S10-911 View SMAD1 siRNA Set I
Transcription Proteins SMAD2 (del SXS) Protein S11-31G Western Blot View SMAD2 (del SXS) Protein
Transcription Proteins SMAD2 Protein S11-30G Kinase Assay, Western Blot View SMAD2 Protein
siRNA Sets SMAD2 siRNA Set I S11-911B View SMAD2 siRNA Set I
Transcription Proteins SMAD3 (del SXS) Protein S12-31G Western Blot View SMAD3 (del SXS) Protein
Transcription Proteins SMAD3 Protein S12-30G Kinase Assay, Western Blot View SMAD3 Protein
siRNA Sets SMAD3 siRNA Set I S12-911B View SMAD3 siRNA Set I
Transcription Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
siRNA Sets SMAD4 siRNA Set I S13-911 View SMAD4 siRNA Set I
Transcription Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein
siRNA Sets SMAD5 siRNA Set I S14-911B View SMAD5 siRNA Set I
Transcription Proteins SMAD9 Protein S17-30G Western Blot View SMAD9 Protein
siRNA Sets SMAD9 siRNA Set I S17-911 View SMAD9 siRNA Set I
Kinase Inhibitors Staurosporine K10-900 View Staurosporine
siRNA Sets STK3 siRNA Set I S24-911 View STK3 siRNA Set I
Active Kinases STK3, Active S24-10G Kinase Assay, Western Blot View STK3, Active
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets TAB1 siRNA Set I T01-911 View TAB1 siRNA Set I
siRNA Sets TAK1 siRNA Set I M15-911 View TAK1 siRNA Set I
Active Kinases TAK1-TAB1, Active M15-13G Kinase Assay, Western Blot View TAK1-TAB1, Active
siRNA Sets TAOK1 siRNA Set I T24-911 View TAOK1 siRNA Set I
Active Kinases TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
siRNA Sets TAOK2 siRNA Set I T25-911 View TAOK2 siRNA Set I
Active Kinases TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
siRNA Sets TAOK3 siRNA Set I T26-911 View TAOK3 siRNA Set I
Active Kinases TAOK3, Active T26-11G Kinase Assay, Western Blot View TAOK3, Active
Growth Factors TGFB1 T831-40N Cell Assay View TGFB1
siRNA Sets TGFB1 siRNA Set I T831-911 View TGFB1 siRNA Set I
Growth Factors TGFB3 T833-40CN Cell Assay View TGFB3
siRNA Sets TGFB3 siRNA Set I T833-911 View TGFB3 siRNA Set I
Active Kinases TGFBR1 (ALK5), Active T07-11BG Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Active Kinases TGFBR1 (ALK5), Active T07-11G Kinase Assay, Western Blot View TGFBR1 (ALK5), Active
Active Kinase Mutants TGFBR1 Mutant (T204D), Active T07-13G Kinase Assay View TGFBR1 Mutant (T204D), Active
Peptide Substrates TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
siRNA Sets TGFBR1 siRNA Set I T07-911B View TGFBR1 siRNA Set I
Unactive Kinases TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
siRNA Sets TGFBR2 siRNA Set I T08-911B View TGFBR2 siRNA Set I
Active Kinases TGFBR2, Active T08-11BG Kinase Assay, Western Blot View TGFBR2, Active
Active Kinases TGFBR2, Active T08-11G Kinase Assay, Western Blot View TGFBR2, Active
Cytokines TNF-alpha T860-40N Cell Assay View TNF-alpha
siRNA Sets TNF-alpha siRNA Set I T860-911 View TNF-alpha siRNA Set I
Cytokines TNFB T861-40N Cell Assay View TNFB
siRNA Sets TNFB siRNA Set I T861-911 View TNFB siRNA Set I
Kinase Protein TP53RK Protein T29-34G Western Blot View TP53RK Protein
siRNA Sets TP53RK siRNA Set I T29-911 View TP53RK siRNA Set I
Adaptor Proteins TRAF1 Protein T56-30G Western Blot View TRAF1 Protein
Adaptor Proteins TRAF2 Protein T57-30G Western Blot View TRAF2 Protein
siRNA Sets TRAF2 siRNA Set I T57-911 View TRAF2 siRNA Set I
siRNA Sets TRAF3 siRNA Set I T58-911 View TRAF3 siRNA Set I
Cytokines TRAIL T880-40N Cell Assay View TRAIL
siRNA Sets TRAIL siRNA Set I T880-911 View TRAIL siRNA Set I
Cellular Proteins VAV1 Protein V14-31G Western Blot View VAV1 Protein
siRNA Sets VAV1 siRNA Set I V14-911 View VAV1 siRNA Set I
siRNA Sets VRK1 siRNA Set I V01-911 View VRK1 siRNA Set I
Active Kinases VRK1, Active V01-10G Kinase Assay, Western Blot View VRK1, Active
siRNA Sets VRK2 siRNA Set I V02-911 View VRK2 siRNA Set I
Active Kinases VRK2, Active V02-11G Kinase Assay, Western Blot View VRK2, Active
Kinase Protein VRK3 Protein V03-30G Western Blot View VRK3 Protein
siRNA Sets VRK3 siRNA Set I V03-911 View VRK3 siRNA Set I
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
siRNA Sets ZAK siRNA Set I Z01-911 View ZAK siRNA Set I
Active Kinases ZAK, Active Z01-10G Kinase Assay, Western Blot View ZAK, Active
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
JNK/SAPK Pathway Product Listing Found: Total 195 Products Matching Research Category JNK/SAPK Pathway
Product Type Product Name Catalog Number Application Pack Sizes
Kinase Activators 8-pCPT-2-O-Me-cAMP-AM R46-905 View 8-pCPT-2-O-Me-cAMP-AM
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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Lipid Kinases Active Lipid Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Enzymes Active Proteases Active Proteases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Epigenetic Enzyme Activators Epigenetic Enzyme Activators
Biochemical Compounds Epigenetic Enzyme Inhibitors Epigenetic Enzyme Inhibitors
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds Phosphatase Inhibitors Phosphatase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dihydropyrimidinase Dihydropyrimidinase
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Kinase Mutant Proteins Kinase Mutant Proteins
Signaling Proteins Kinase Protein Kinase Protein
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Phospholipase C Proteins Phospholipase C Proteins
Signaling Proteins Superoxide Dismutase Superoxide Dismutase
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Lipid Substrates Lipid Substrates
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selectivity Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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