PI3K (p110 beta/p85 beta) Active Enzymes Active Kinases


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PI3K (p110 beta/p85 beta), Active (P28-10BH)
Catalog Number Pack Size Price (USD)  
PI3K (p110 beta/p85 beta), Active P28-10BH-05 5 ug $205   PI3K (p110 beta/p85 beta), Active Add to Cart
PI3K (p110 beta/p85 beta), Active P28-10BH-10 10 ug $295   PI3K (p110 beta/p85 beta), Active Add to Cart
PI3K (p110 beta/p85 beta), Active P28-10BH-BULK BULK CONTACT US  
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Bulk Pricing for PI3K (p110 beta/p85 beta), Active

Product Data Sheet(s)




Description: Recombinant full-length human p110 beta and human p85 beta were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_006219 , NM_005027
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~111 kDa (p110β), ~88 kDa (p85β)

Gene Aliases: p110β: PI3K, PIK3C1, PI3Kbeta, MGC133043, p110-BETA, DKFZp779K1237 p85β: PIK3R2, P85B, p85-BETA

Scientific Background: PI3K phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit (1). PI3K plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PI3K sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B (2).

References: 
1. Hu, P.et.al: Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Molec. Cell. Biol. 13: 7677-7688, 1993.

2. Jackson, S. P.et.al: PI 3-kinase p110-beta: a new target for antithrombotic therapy. Nature Med. 11: 507-514, 2005.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PI3K (p110 beta/p85 beta), Active Research Areas

The PI3K (p110 beta/p85 beta), Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



PI3K (p110 beta/p85 beta), Active Related Products Found: Total 13 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins PI3K (p85 alpha) Protein P31-30H Kinase Assay, Western Blot View PI3K (p85 alpha) Protein
Signaling Proteins PI3K (p85 beta) Protein P31-30BH Kinase Assay, Western Blot View PI3K (p85 beta) Protein
Enzymes PI3K (p110 alpha(E545K)/p85 alpha), Active P27-15H Kinase Assay, Western Blot View PI3K (p110 alpha(E545K)/p85 alpha), Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-10H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PI3K (p110 delta/p85 alpha), Active P30-10H Kinase Assay, Western Blot View PI3K (p110 delta/p85 alpha), Active
Enzymes PI3K (p120 gamma), Active P29-10H Kinase Assay, Western Blot View PI3K (p120 gamma), Active
Enzymes PIK3C3 (Vps34), Active P26-10G Kinase Assay, Western Blot View PIK3C3 (Vps34), Active
Enzymes PIK3C2G, Active P25-11G Kinase Assay, Western Blot View PIK3C2G, Active
Signaling Proteins PI3K (p55 gamma) Protein P31-30CH Western Blot View PI3K (p55 gamma) Protein
Signaling Proteins PI3K (p65 alpha) Protein P31-31H Western Blot View PI3K (p65 alpha) Protein
Enzymes PI3K (p110 alpha/p55 gamma), Active P27-10CH Kinase Assay, Western Blot View PI3K (p110 alpha/p55 gamma), Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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