PI3K (p85 alpha) Protein Cell Signaling Reagents Cellular Proteins


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PI3K (p85 alpha) Protein (P31-30H)
Catalog Number Pack Size Price (USD)  
PI3K (p85 alpha) Protein P31-30H-20 20 ug $195 PI3K (p85 alpha) Protein  40% OFF   PI3K (p85 alpha) Protein Add to Cart
PI3K (p85 alpha) Protein P31-30H-50 50 ug $395 PI3K (p85 alpha) Protein  40% OFF   PI3K (p85 alpha) Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human PI3K (p85alpha) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_181523
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~86 kDa

Gene Aliases: PIK3R1, GRB1, p85-ALPHA

Scientific Background: The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. p85α modulates the interaction between PI3K and platelet-derived growth factor receptor (1). Furthermore, estrogen receptor isoform ER-alpha binds in a ligand-dependent manner to the p85-alpha regulatory subunit of PI3K. Stimulation with estrogen increases ER-alpha-associated PI3K activity, leading to the activation of protein kinase B/AKT and endothelial nitric oxide synthase (eNOS) (2).

References: 
1. Skolnik, E. Y. Et al: Cloning of PI3-kinase associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65: 83-90, 1991.

2. Simoncini, T. et al: Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 407: 538-541, 2000.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PI3K (p85 alpha) Protein Research Areas

The PI3K (p85 alpha) Protein product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



PI3K (p85 alpha) Protein Related Products Found: Total 15 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PI3K (p110 alpha(E545K)/p85 alpha), Active P27-15H Kinase Assay, Western Blot View PI3K (p110 alpha(E545K)/p85 alpha), Active
Enzymes PI3K (p110 delta/p85 alpha), Active P30-10H Kinase Assay, Western Blot View PI3K (p110 delta/p85 alpha), Active
Enzymes PI3K (p120 gamma), Active P29-10H Kinase Assay, Western Blot View PI3K (p120 gamma), Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-10H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI4K2B, Active P22-10G Kinase Assay, Western Blot View PI4K2B, Active
Enzymes PI4KB, Active P32-10G Kinase Assay, Western Blot View PI4KB, Active
Enzymes PI3K (p110 beta/p85 beta), Active P28-10BH Kinase Assay, Western Blot View PI3K (p110 beta/p85 beta), Active
Signaling Proteins PI3K (p85 beta) Protein P31-30BH Kinase Assay, Western Blot View PI3K (p85 beta) Protein
Enzymes PIK3C3 (Vps34), Active P26-10G Kinase Assay, Western Blot View PIK3C3 (Vps34), Active
Enzymes PIK3C2G, Active P25-11G Kinase Assay, Western Blot View PIK3C2G, Active
Signaling Proteins PI3K (p55 gamma) Protein P31-30CH Western Blot View PI3K (p55 gamma) Protein
Signaling Proteins PI3K (p65 alpha) Protein P31-31H Western Blot View PI3K (p65 alpha) Protein
Enzymes PI3K (p110 alpha/p55 gamma), Active P27-10CH Kinase Assay, Western Blot View PI3K (p110 alpha/p55 gamma), Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
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Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
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Signaling Proteins Cellular Proteins Cellular Proteins
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Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
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Signaling Reagents
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Antibodies
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Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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