PI4K2B Active Enzymes Active Kinases


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PI4K2B, Active (P22-10G)

Catalog Number Pack Size Price (USD)  
PI4K2B, Active P22-10G-05 5 ug $205   PI4K2B, Active Add to Cart
PI4K2B, Active P22-10G-10 10 ug $295   PI4K2B, Active Add to Cart
PI4K2B, Active P22-10G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Full-length recombinant human PI4K2B was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_018323
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~84 kDa

Gene Aliases: FLJ11105; PI4KIIB; PIK42B

Scientific Background: PI4K2B is a member of the phosphatidylinositol 4-kinase family (PI4K) that phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate which are immediate precursor of several important signaling and scaffolding molecules. PI4K2B is primarily a cytosolic PI4K that is recruited to membranes where it stimulates phosphatidylinositol 4,5-bisphosphate syntheses (1). PI4K2B uses phosphatidylinositol as their primary substrate and has no activity on phosphatidylinositol monophosphates. PI4K2B is a restricted minor histocompatibility antigen in patients that had been successfully treated with donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation (2).

References
1. Balla, A. et.al: Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J. Biol. Chem. 277: 20041-20050, 2002.

2. Griffioen, M. et.al: Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity. Proc. Nat. Acad. Sci. 105: 3837-3842, 2008.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PI4K2B, Active Research Areas

The PI4K2B, Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



PI4K2B, Active Related Products Found: Total 13 Related Products
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Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PI3K (p120 gamma), Active P29-10H Kinase Assay, Western Blot View PI3K (p120 gamma), Active
Signaling Proteins PI3K (p85 alpha) Protein P31-30H Kinase Assay, Western Blot View PI3K (p85 alpha) Protein
Enzymes PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active P27-15H Kinase Assay View PI3K (p110 alpha(E545K)/p85 alpha) Mutant, Active
Enzymes PI4K2A, Active P21-10G Kinase Assay, Western Blot View PI4K2A, Active
Enzymes PI4KB, Active P32-10G Kinase Assay, Western Blot View PI4KB, Active
Enzymes PIP5K1C, Active P16-10CG Kinase Assay, Western Blot View PIP5K1C, Active
Enzymes PIK3C3 (Vps34), Active P26-10G Kinase Assay, Western Blot View PIK3C3 (Vps34), Active
Enzymes PIK3C2G, Active P25-11G Kinase Assay, Western Blot View PIK3C2G, Active
Signaling Proteins PI4KA Protein P31-30G Western Blot View PI4KA Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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