Storage, Stability and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Phosphatase Assay, Western Blot
: ~62 kDa
: PP1A is a serine/threonine specific protein phosphatase family which is involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. PP1A is one of the three catalytic subunits of protein phosphatase 1 (PP1) (1). PP1A functions as a suppressor of learning and memory and as a potential mediator of cognitive decline during aging (2).PP1A is also play a main role in splice site selection and is an important regulator of cardiac function.
1. Cohen, P.et.al: Protein phosphatases come of age. J. Biol. Chem. 264: 21435-21438, 1989.
2. Genoux, D. et.al: Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002.
: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
||Specific Activity: Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The PP1A, Active product can be utilized in the following research areas, but not limited to:
Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases