SGK1 Unactive Cell Signaling Reagents Unactive Kinases


HomeCell Signaling Reagents - Unactive KinasesSGK1, Unactive

SGK1, Unactive (S06-15G)

Catalog Number Pack Size Price (USD)  
SGK1, Unactive S06-15G-20 20 ug $195   SGK1, Unactive Add to Cart
SGK1, Unactive S06-15G-50 50 ug $395   SGK1, Unactive Add to Cart
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Product Data Sheet(s)




Description: Recombinant human SGK1 (60-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 60-end
Genbank Number: NM_005627
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~72 kDa

Gene Aliases: SGK

Scientific Background: SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase (1). SGK1 mRNA is expressed in all tissues and the level of SGK1 mRNA is increased by stimulation with serum or dexamethasone. SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1 (2). SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1.

References
1. Kobayashii, T. et al: Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J. 1999 Nov 15;344 Pt 1:189-97.

2. Brunet, A. et al: Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol. 2001 Feb;21(3):952-65.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




SGK1, Unactive Research Areas

The SGK1, Unactive product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling



SGK1, Unactive Related Products Found: Total 5 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
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Enzymes SGK2, Active S07-10G Kinase Assay, Western Blot View SGK2, Active
Enzymes SGK3, Active S08-10G Kinase Assay, Western Blot View SGK3, Active
Signaling Proteins SGK1, Unactive S06-15G Kinase Assay, Western Blot View SGK1, Unactive
Signaling Proteins SGK3, Unactive S08-14G Kinase Assay, Western Blot View SGK3, Unactive


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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