Description: Rabbit Polyclonal Antibody

Specificity: Recognizes the p38γ protein

Cited Applications: WB

Cross Reactivity: Western blot human p38γ

p38γ from other species may also be detectable.

Host: Rabbit

Immunogen: C-terminal peptide of p38γ conjugated to ovalbumin

Formulation: TBS at pH 7.2, 50% glycerol

Purification: Affinity chromatography

Stability: Store at 4°C (add 0.1% NaN₃) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background: p38γ is a member of the p38 MAPK family which is activated in response to stress (1). p38γ gene was mapped to 22q13.3 and functions as a signal transducer during differentiation of myoblasts to myotubes. Enforced localization of p38γ in the nucleus or cytoplasm markedly attenuates the ability of the kinase to induce cell cycle arrest in fibroblasts. p38γ increases basal glucose uptake and decreases DNP- and contraction-stimulated glucose uptake, partially by affecting levels of glucose transporter expression in skeletal muscle (2).

References: 1. Li, Z. et al: The primary structure of p38-gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228: 334-340, 1996.

2. Ho, RC. et al: p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R342-9. Epub 2003 Oct 30.

		Sample Western Blot:   Representative western blot (1:1000) using 20ng of p38α, p38β, p38γ, and p38δ recombinant protein.

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