Anti-SMAD2 Antibodies Isoform Specific Antibodies


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Anti-SMAD2 (S11-63R)

Catalog Number Pack Size Price (USD)  
Anti-SMAD2 S11-63R-100 100 ug $315   Anti-SMAD2  Add to Cart
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Bulk Pricing for Anti-SMAD2

Product Data Sheet(s)




Description: Rabbit Polyclonal Antibody
Specificity: Recognizes the SMAD2 protein

Cited Applications: WB

Cross Reactivity: Western blot human SMAD2

SMAD2 from other species may also be detectable

Host : Rabbit

Immunogen: Synthetic peptide corresponding to amino acids 218-222 of human SMAD2

Formulation: PBS, pH7.4, 0.02%NaN3, 50% glycerol

Purification: Affinity chromatography

Stability: Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.

Scientific Background: SMADs are essential intracellular components for the signal transduction of TGFβ family members. SMAD2 is an intracellular mediator of TGFβ family and activin type 1 receptor (1). SMAD2 mediate TGFβ signaling to regulate cell growth and differentiation. SMAD2 is released from cytoplasmic retention by TGFβ receptor-mediated phosphorylation. The phosphorylated SMAD2 then forms a heterodimeric complex with SMAD4, and this complex translocates from cytoplasm into nucleus. By interacting with DNA-binding proteins, SMAD2 complexes then positively or negatively regulate the transcription of target genes. Inactivating mutations in SMAD2 have been found in various cancers (2).

References
1. Masayuki, F. et al: Identification and Characterization of Constitutively Active Smad2 Mutants: Evaluation of Formation of Smad Complex and Subcellular Distribution. Molecular Endocrinol. 2000; 14 (10): 1583-1591.

2. Eppert, K. et al: MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 1996; 86: 543-552.



  Sample Data:  Representative Western blot with Anti-SMAD2 (1:1000) using 15ng of GST-tagged human recombinant SMAD1, SMAD2, SMAD3, SAMD4 and SMAD5.


  Sample Data:  Representative Western blot with Anti-SMAD2 (1:500) using 20 μg, 40 μg and 65 μg of Jurkat cell lysate.




Anti-SMAD2 Research Areas

The Anti-SMAD2 product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, WNT Signaling



Anti-SMAD2 Related Products Found: Total 5 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins SMAD2 Protein S11-30G Kinase Assay, Western Blot View SMAD2 Protein
Signaling Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
Signaling Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
Signaling Proteins SMAD3 Protein S12-30G Kinase Assay, Western Blot View SMAD3 Protein
Signaling Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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