JNK3 Active Enzymes Active Kinases


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JNK3, Active (M35-10BG)

Catalog Number Pack Size Price (USD)  
JNK3, Active M35-10BG-05 5 ug $205   JNK3, Active Add to Cart
JNK3, Active M35-10BG-10 10 ug $295   JNK3, Active Add to Cart
JNK3, Active M35-10BG-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full-length human JNK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full Length
Genbank Number: NM_002753
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~71 kDa

Gene Aliases: MAPK10; JNK3A, MGC50974, PRKM10, p493F12, p54bSAPK; FLJ12099, FLJ33785

Scientific Background: JNK3 is a member of the c-Jun N-terminal kinases (JNKs) which are part of the mitogen-activated protein (MAP) kinase family, and regulate signal transduction in response to environmental stress. JNK3 phosphorylates various transcription factors such as ATF2, Elk-1 and members of the Jun family (1). Activation and nuclear localization of JNK3, a neuronal-specific isoform of JNK, has been associated with hypoxic and ischemic damage of CA1 neurons in the hippocampus. Knockout mice lacking JNK3 showed reduced apoptosis of hippocampal neurons and reduced seizure induced by kainic acid, a glutamate-receptor agonist (2).

References
1. Gupta, S. et al: Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996 Jun 3; 15(11):2760-70.

2. Yang, D D. et al: Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 1997 Oct 23; 389(6653):865-70.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




JNK3, Active Research Areas

The JNK3, Active product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Ser/Thr Kinases



JNK3, Active Related Products Found: Total 11 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
Enzymes JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Signaling Proteins JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Antibodies Anti-JNK2/3 M34-63R WB View Anti-JNK2/3
Antibodies Anti-JNK2 M34-60M WB, IP View Anti-JNK2
Signaling Proteins JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
Enzymes MLK2, Active M18-11G Kinase Assay, Western Blot View MLK2, Active
Enzymes MLK1, Active M17-11G Kinase Assay, Western Blot View MLK1, Active
Enzymes MLK3, Active M19-11G Kinase Assay, Western Blot View MLK3, Active
Enzymes JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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