KAT3B (EP300) Protein Cell Signaling Reagents Acetyl/Methyltransferases


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KAT3B (EP300) Protein (K312-31BG)

Catalog Number Pack Size Price (USD)  
KAT3B (EP300) Protein K312-31BG-20 20 ug $195   KAT3B (EP300) Protein Add to Cart
KAT3B (EP300) Protein K312-31BG-50 50 ug $395   KAT3B (EP300) Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant human KAT3B (EP300) (532-1153; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 532-1153; contains the catalytic domain
Genbank Number: NM_001429
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~120 kDa

Gene Aliases: KAT3B; EP300; p300

Scientific Background: KAT3B (also known as EP300) encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein that functions as a histone acetyltransferase. KAT3B regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. KAT3B binding is a highly accurate process and can be used for identifying enhancers and their associated activities (1). KAT3B is also useful in the study of the role of tissue-specific enhancers in human biology and diseases on a genome wide scale. Defects in KAT3B gene are a cause of Rubinstein-Taybi syndrome that play a important role in epithelial cancer and act as a classic tumor suppressor gene (2).

References
1. Visel, A. et.al: ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature 457: 854-858, 2009.

2. Gayther, S. A. et.al: Mutations truncating the EP300 acetylase in human cancers. Nature Genet. 24: 300-303, 2000.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




KAT3B (EP300) Protein Research Areas

The KAT3B (EP300) Protein product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway



KAT3B (EP300) Protein Related Products Found: Total 8 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins KAT9 (ELP3) Protein K318-30G Western Blot View KAT9 (ELP3) Protein
Antibodies Anti-Acetylated Lysine, Biotin Conjugated L95-66BR WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine, Biotin Conjugated
Antibodies Anti-Acetylated Lysine, FITC Conjugated L95-66CR For direct immunofluorescence assay View Anti-Acetylated Lysine, FITC Conjugated
Antibodies Anti-Acetylated Lysine, HRP Conjugated L95-66DR WB, ELISA, IP, IHC, IF View Anti-Acetylated Lysine, HRP Conjugated
Signaling Proteins KAT3A (CREBBP) Protein K312-31G Western Blot View KAT3A (CREBBP) Protein
Signaling Proteins KAT8 (MYST1) Protein K317-31G Western Blot View KAT8 (MYST1) Protein
Signaling Reagents Histone H3 Peptide (1-21) H12-58 Acetylation/Methylation Assays View Histone H3 Peptide (1-21)
Signaling Proteins KAT4 Protein K313-31G Western Blot View KAT4 Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Protein Kinases Protein Kinases
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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