PTEN Protein Cell Signaling Reagents Cellular Proteins


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PTEN Protein (P23-34G)

Catalog Number Pack Size Price (USD)  
PTEN Protein P23-34G-20 20 ug $195   PTEN Protein Add to Cart
PTEN Protein P23-34G-50 50 ug $395   PTEN Protein Add to Cart
PTEN Protein P23-34G-BULK BULK CONTACT US  
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Bulk Pricing for PTEN Protein

Product Data Sheet(s)




Description: Recombinant full-length human PTEN was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full Length
Genbank Number: NM_000314
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~76 kDa

Gene Aliases: BZS, MHAM, TEP1, MMAC1, PTEN1, MGC11227

Scientific Background: PTEN (phosphatase and tensin homolog) is a tumor suppressor that is frequently mutated in a large number of cancers (1). PTEN has phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and is responsible for negatively regulating the intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells. PTEN functions as a tumor suppressor by negatively regulating the PI3K/AKT signaling pathway (2).

References
1. Butler, M.G. et al: Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J. Med. Genet. 2005;42(4):318-21.

2. Steck, P.A. et aal: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 1997; 15(4):356-62



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PTEN Protein Research Areas

The PTEN Protein product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Phosphatases, WNT Signaling



PTEN Protein Related Products Found: Total 16 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes AKT1, Active A16-10G Kinase Assay, Western Blot View AKT1, Active
Signaling Proteins AKT1, Unactive A16-14G Kinase Assay, Western Blot View AKT1, Unactive
Enzymes AKT2, Active A17-10G Kinase Assay, Western Blot View AKT2, Active
Enzymes AKT2, Active A17-10H Kinase Assay, Western Blot View AKT2, Active
Enzymes AKT3, Active A18-10G Kinase Assay, Western Blot View AKT3, Active
Signaling Proteins AKT3, Unactive A18-14G Kinase Assay, Western Blot View AKT3, Unactive
Enzymes HER2, Active E27-11G Kinase Assay, Western Blot View HER2, Active
Enzymes FGR, Active F10-10G Kinase Assay, Western Blot View FGR, Active
Enzymes FLT1, Active F11-11G Kinase Assay, Western Blot View FLT1, Active
Enzymes FLT3, Active F12-11G Kinase Assay, Western Blot View FLT3, Active
Enzymes IGF1R, Active I02-11H Kinase Assay, Western Blot View IGF1R, Active
Enzymes InsR, Active I08-11G Kinase Assay, Western Blot View InsR, Active
Enzymes PI3K (p110 alpha/p85 alpha), Active P27-18H Kinase Assay, Western Blot View PI3K (p110 alpha/p85 alpha), Active
Enzymes PI3K (p110 beta/p85 alpha), Active P28-10H Kinase Assay, Western Blot View PI3K (p110 beta/p85 alpha), Active
Enzymes PDK1, Active P14-10H Kinase Assay, Western Blot View PDK1, Active
Enzymes PTEN, Active P23-20G Phosphatase Assay, Western Blot View PTEN, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Protein Kinases Protein Kinases
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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